Humans have about 20,000 genes (give or take), far fewer genes than many so-called “primitive” animals, like Daphina pulex, a.k.a. the water flea, which has about 31,000. How then are humans able to be so complex with less genetic material? One answer: alternative splicing.
With a new tactic in immunotherapy, Derya Unutmaz and his team has successfully engineered an atypical type of immune cell, the human mucosal-associated T cell, with the capabilities to overcome challenges in standard CAR-T cell treatment.