The Mouse Resource for Craniofacial Research is a comprehensive resource providing mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes such as cleft palate.
The Mouse Resource for Craniofacial Research is a comprehensive resource providing mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes such as cleft palate. The Resource is composed of new inducible Cre-driver lines we designed specifically to support craniofacial research; spontaneous mutation strains with craniofacial defect phenotypes that arose in JAX colonies; and mouse models developed in other labs and donated to the resource. We provide a repository for rederivation, cryopreservation, genetic quality control, and distribution of live colonies of new and existing mouse models and tool strains relevant to craniofacial research.
Researchers who would like to share their mouse models with the scientific community are encouraged to donate a strain to the repository.
Please reference the Mouse Resource for Craniofacial Research in citations acknowledging use of the resource.
This resource grew out of two separate NIH programs. The FaceBase Consortium, a five-year initiative to construct the middle region of the human face and precisely define the genetics underlying common developmental disorders of the human face, provided support from 2009-2014 (DE020052). Separately, development of spontaneous mutant models of craniofacial disorders began under an R01 (EY015073) between 2009-2013. Combined, these two programs formed the foundation for a diverse resource of models for craniofacial research.
Current support for the resource comes from The Jackson Laboratory and the sale of mice.
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Odgren PR, Pratt CH, Mackay CA, Mason-Savas A , Curtain M, Shopland L, Ichicki T, Sundberg JP , Donahue LR. 2010. Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies. PLoS One Apr1:5(4):e9959.PMCID:2848607.