Genetic Resource Science

Genetic Resource Science (GRS) initiates and develops resource-generating research. Our team:

  • Identifies and implements innovative technologies for genetic research.
  • Makes and distributes new mouse models.
  • Provides extensive genetic and phenotypic information on JAX mouse strains.

We supply the scientific community with the most comprehensive collection of mouse genetic resources and mouse-related technologies, such as ES cells and tool strains.  Our work strengthens and diversifies the resources available for basic, biomedical and preclinical research.

GRS offers support for scientists already using mice and those just starting to explore how a mouse model could enhance the progress of their discoveries.


To develop new research resources, GRS scientists conduct hypothesis-driven research in their individual areas of interest.  We also adapt technologies to enhance them for use in our own research or that of other scientists.

Our team has a broad base of experience, enabling us to take on projects that require a variety of expertise. We can partner directly with other scientists to help them resolve research issues that require special strains, resources or tools.


Our Repository maintains more than 1,800 strains live as breeding colonies for rapid distribution and over 6,000 others as cryopreserved stock or DNA for dissemination to the worldwide scientific community.  We are experts at genetic background stabilization, and we maintain the highest standards of quality control.  Every strain has an allele-specific genotyping assay, and breeders and offspring are genotyped when a clinical phenotype isn't apparent. Data sheets for each strain document performance, husbandry, genotype, phenotype and more.

Our research and development programs add many new models to the Repository each year and enhance the value of available strains.

GRS Currated List

Stefanie Stein Jeffrey, M.D in lab with an associate

Partnerships and Collaborations

We work closely with foundations, biotech firms and pharmaceutical companies to develop new models and further translational research.

Work with Genetic Resource Science
Associate Professor Zhong-wei Zhang, Ph.D. in lab

Resource and Model Development

We develop models for basic research, tools for exploring disease mechanisms on a molecular level and precision models of human disease.

Resource and model development


Genetic Resource Science is funded by NIH research and resource grants, private foundations and revenue from the distribution of mice to researchers.

National Cancer Institute
National Heart, Lung and Blood Institute
National Human Genome Research Institute
National Institute of Child Health and Human Development
National Institute of Dental and Craniofacial Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Neurological Disorders and Stroke
Office of Research Infrastructure Programs, Office of the Director, NIH
ALS Therapy Alliance
Amyotrophic Lateral Sclerosis Association
Chordoma Foundation
Cicatricial Alopecia Research Foundation
Council for Nail Disorders
Dravet Syndrome Foundation
Families of SMA
Friedreich's Ataxia Research Alliance
March of Dimes
Michael J. Fox Foundation
Spinal Muscular Atrophy Foundation
The Tow Foundation