Bar Harbor, ME
Researches mice as a model for human neurodegenerative disease, with an emphasis on best practices for research and preclinical drug testing.
My lab focuses on modeling human neurodegenerative disease in mice, with an emphasis on optimum use and best practices for research and preclinical drug testing. As part of the Mouse Model Repository at The Jackson Laboratory, my lab works with the NIH and multiple disease foundations to improve existing mouse models, identify modifier genes, and generate new models that will facilitate therapeutic development. Our goal is to work with foundations, foundation partners and the scientific community to facilitate the rapid characterization, standardization and consistent use of mouse models, with the aim of accelerating treatment discovery. Presently we are focused on Spinal Muscular Atrophy (SMA), Friedreich's Ataxia, amyotrophic lateral sclerosis (ALS), and Rett syndrome.
University of Maine, Orono, ME
The University of Pittsburgh, Pittsburgh, PA
Director, Repository, and Research Scientist, Genetic Resource Science, The Jackson Laboratory, Bar Harbor, ME
Associate Director and Research Scientist, Genetic Resource Science, The Jackson Laboratory, Bar Harbor, ME
Mouse Repository Operations Manager and Associate Research Scientist, The Jackson Laboratory, Bar Harbor, ME
Senior Scientific Curator, Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME
Postdoctoral Associate, Laboratory of Dr. David Hosford, Duke University, Durham North Carolina
Predoctoral Associate, Laboratory of Dr. Wayne Frankel, The Jackson Laboratory, Bar Harbor, ME
Senior Research Assistant, Laboratory of Dr. Wayne Frankel, The Jackson Laboratory, Bar Harbor, ME
Research Assistant, Laboratory of Dr. Benjamin Taylor, The Jackson Laboratory, Bar Harbor, ME
Research Technician, Laboratory of Dr. Mary Edmonds, The University of Pittsburgh, Pittsburgh, PA
In work involving several new generations of mouse model development, Jackson Laboratory (JAX) researchers have tested a therapeutic intervention for spinal muscular atrophy (SMA) that restores some function lost due to a mutation in one gene (SMN1) and amplifies the levels of protective genes (SMN2). Moreover, unlike current interventions, the therapy appears to work after symptoms of SMA have already appeared, and may not need to be administered directly into the central nervous system.
Two 2011 studies demonstrate that restoring or increasing spinal motor neuron (SMN) protein alleviates or even reverses disease in spinal muscular atrophy (SMA) mouse models.
Huntington's disease hasn't stopped Cathy Alley from pursuing her passion for live music or supporting the search for cures for her disease.
A novel, allelic series of spinal muscular atrophy (SMA) mouse models have been created that differ in SMN expression levels and SMA-related disease severity.
Scientists are rapidly engineering mice that model these genetic lesions which will be critical for understanding pathogenesis of these diseases.
This course is a modern survey of heredity, disease, genetics in experimental animals and humans, and molecular genetics in...
Dr. Burgess is studying Charcot-Marie Tooth syndrome, a genetic neurological disorder that causes damage to the peripheral nerves, the...
Genetic diversity should be accounted for in pre-clinical tests, and researchers need to select the right model system to mimic human...
Families have banded together from across the globe to make awareness and research for SMARD a reality.
Use JAX® In Vivo Services to test your DMD-related therapeutics in C57BL/10ScSn-Dmdmdx/J (mdx) mice.
JAX distributes well-characterized, preclinical mouse models to accelerate drug discovery for rare and orphan diseases.
We engineer new models and enhance existing models through genetic standardization and characterization to ensure reproducibility of data...
We partner with foundations, pharmaceutical and biotech companies, and other scientists to research treatments for uncommon...
JAX-designed SNP panels are used to develop congenic lines in your lab, confirm strain identity, and monitor genetic...
Researches the molecular pathways of human degenerative muscle diseases.
Over 30,000 peer-reviewed publications cite use of JAX® Mice strains. Hundreds of new papers referencing JAX® Mice strains are published...
The Jackson Laboratory can save you time spent processing, money spent on reagents, and space used for housing mice by providing you with...
350 million people are affected by rare and orphan disease. The Rare and Orphan Disease Center conducts research to better...
Our Breeding Services makes managing your mouse colonies easy and affordable. We'll make sure you get the mice you need when...
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian...