Maximiliano Presa, Postdoctoral Associate

Maximiliano Presa, Ph.D.

Technology and Resource Development Scientist

Focused on understanding the genetic aspects involved in the development of type 1 diabetes (T1D).

The Rare and Orphan Disease Center

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About Maximiliano Presa, Ph.D.

I am interested in the study of the genetic control of the immune system. My research is focused on the understanding of the genetic aspects involved in the development of type 1 diabetes (T1D). My ongoing project is focused on the study of the thymic negative selection process, which is defective in both human T1D patients and NOD mice. Our previous studies found that a region on chromosome 7 (Idd7) in NOD mice, which has a potential human homolog, contains a gene that contributes to T1D development by significantly contributing to the failed thymic negative selection of autoreactive T lymphocytes (T-cells). The overall objective of this project is to test that an over-expressed version of the (Nfkbid) gene located within the Idd7 region is an important contributor to the failed thymic negative selection of T1D inducing T-cells in NOD mice. This study will contribute to the identification of a possible new genetically controlled function contributing to T1D development in NOD mice, and also possibly humans. Such information could ultimately contribute to the development of possible novel clinically applicable interventions for the prevention of T1D in humans deemed to be at high future disease risk.

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Research HighlightDecember 11, 2018
The unexpected advantages of outbred mice in research
Recently developed outbred mouse populations, such as the diversity outbred (DO) mice at The Jackson Laboratory (JAX), have created research options that parallel or even exceed human genetic diversity. Research with DO mice offers a full range of genetic diversity, and therefore more generalizability of responses across populations.
Tech CornerOctober 11, 2018
Precision medicine and making sense of data
JAX professor calls for concerted effort to align data across patients and systems with comparable and consistent formats and contextual meaning.
Press ReleaseOctober 09, 2018
Advancing therapeutic gene editing
NIH awards $3.5M to JAX under multi-institution Somatic Cell Genome Editing program.
Press ReleaseOctober 02, 2018
Addiction: The microbiome link
The National Institute on Drug Abuse has made a $4M grant to JAX scientists to explore the roles of the microbiome and genetics in substance use disorders.

Blog PostDecember 11, 2018
Nesting dolls and Narnia
If movies were true to real life, matryoshka dolls would provide a good analogy for genomics research.
Search MagazineOctober 09, 2018
Of mighty mice and men
Pioneering scientist Se-Jin Lee, a leader in the study of muscle development, moves his groundbreaking research program to JAX.
Featured ArticleOctober 03, 2018
Type 2 Diabetes: It's Personal
Assistant Professor Michael L. Stitzel, Ph.D. gave a TED-style talk on new approaches to type 2 diabetes as part of the Laboratory’s JAXtaposition speaker series. Photo by Charles Camarda.
Press ReleaseSeptember 27, 2018
Probing the genetics of islet stress and resilience in type 2 diabetes
$2.8 million Department of Defense grant will fund JAX research defining gene-environment interactions of islet resilience and type 2 diabetes