David Bergstrom, Ph.D.

Research Scientist

Bar Harbor, ME

Researches inner ear development and the genetics underlying vestibular function dysfunction, as well as dwarfism and skeletal malformation.

About David E. Bergstrom, Ph.D.

My research group studies mouse models with vestibular (inner ear) defects that may provide insights into balance disorders in humans. I am focusing on mutations that affect the structure and function of the otolithic end organs, small inner-ear structures that act as linear acceleration and gravity receptors. We have identified and characterized genes that are defective in head-tilt (het), head-slant (hslt), and neuromutagenesis facility (nmf) 333 mutant mice, each of which encodes an NADPH oxidase component. Thus, we've hypothesized that a previously unknown inner ear NADPH oxidase complex is necessary for proper development and function of the vestibular system.

I am also studying a mouse model that exhibits sex reversal, craniofacial defects and shortening of the limbs characteristic of some forms of human dwarfism. We have narrowed the genetic defect to a region on mouse Chromosome 7 and are analyzing that region of the genome with the goal of better understanding dwarfism and certain skeletal malformation syndromes in humans.

Education and experience

Education

The Jackson Laboratory
Postdoctoral Fellow
Adv: Dr. Eva M. Eicher
1996-1999

The Jackson Laboratory
Postdoctoral Trainee
Adv: Dr. Elizabeth M. Simpson
1994-1995

University of Illinois at Urbana-Champaign
Ph.D., biology (molecular genetics)
1994

University of Illinois at Urbana-Champaign
M.S., biology
1990

Illinois State University
B.S., biological sciences
1985

Experience

The Jackson Laboratory
Research scientist/Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science
2006-present

The Jackson Laboratory
Research scientist
2004-2005

The Jackson Laboratory
Associate research scientist/research scientist
1999-2004

Grants, Honors, and Accomplishments

NASA Certificate of Appreciation
Space Shuttle Endeavor STS-108
2001

School of Life Sciences Fellowship
University of Illinois
1986

Blog Post March 01, 2016
Collectively, rare diseases are not so rare

A team from The Jackson Laboratory attended a Rare Disease Day 2016 event in Maine to help educate state legislators and staff about the challenges of living with rare diseases, and how JAX is empowering the scientific and medical communities to combat these diseases.
Blog Post December 17, 2014
The ABC’s of choosing a Cre strain to generate KO mice

There are over 500 Cre-recombinase expressing strains available. Learn how can you decide which Cre strain will generate the right KO model for you.
Blog Post November 24, 2014
Going beyond Cre-lox

New recombination systems provide refinement of the Cre-lox system, to spatiotemporally regulate gene expression, creating more sophisticated mouse models.
Blog Post September 12, 2013
Cre-lox myths busted

Many mouse strains expressing Cre have unexpected phenotypes that may complicate the interpretation of your experiments. Here we dispel four common Cre-lox myths.

The Search Magazine Article June 26, 2017
The muscle man

Neuromuscular diseases start by hampering mobility and progress to threatening vital processes like breathing and swallowing. Greg Cox wants to knock them all out.
Blog Post September 16, 2013
12 things you don't know about Cre-lox

Learn how Cre-lox strains may not behave exactly as expected, and how to use this system in more creative ways.
Blog Post May 05, 2011
Slicing and dicing Cre/lox: part 1

The Cre/lox system enables sophisticated control over the timing and location of gene expression. Learn the details about Cre-lox that too often go overlooked.
JAX Notes May 19, 2006
The Cre-lox and FLP-FRT systems

Both the Cre-lox and FLP-FRT technologies allow the location and timing of gene expression to be closely regulated in a mouse.