David E. Bergstrom, Ph.D.

Research Scientist

Researches inner ear development and the genetics underlying vestibular function dysfunction, as well as dwarfism and skeletal malformation.

The Jackson Laboratory Cancer Center

Contact me at: 207-288-6609

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About David E. Bergstrom, Ph.D.

My research group studies mouse models with vestibular (inner ear) defects that may provide insights into balance disorders in humans. I am focusing on mutations that affect the structure and function of the otolithic end organs, small inner-ear structures that act as linear acceleration and gravity receptors. We have identified and characterized genes that are defective in head-tilt (het), head-slant (hslt), and neuromutagenesis facility (nmf) 333 mutant mice, each of which encodes an NADPH oxidase component. Thus, we've hypothesized that a previously unknown inner ear NADPH oxidase complex is necessary for proper development and function of the vestibular system.

I am also studying a mouse model that exhibits sex reversal, craniofacial defects and shortening of the limbs characteristic of some forms of human dwarfism. We have narrowed the genetic defect to a region on mouse Chromosome 7 and are analyzing that region of the genome with the goal of better understanding dwarfism and certain skeletal malformation syndromes in humans.

Education and experience

Education

The Jackson Laboratory
Postdoctoral Fellow
Adv: Dr. Eva M. Eicher
1996-1999

The Jackson Laboratory
Postdoctoral Trainee
Adv: Dr. Elizabeth M. Simpson
1994-1995

University of Illinois at Urbana-Champaign
Ph.D., biology (molecular genetics)
1994

University of Illinois at Urbana-Champaign
M.S., biology
1990

Illinois State University
B.S., biological sciences
1985

Experience

The Jackson Laboratory
Research scientist/Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science
2006-present

The Jackson Laboratory
Research scientist
2004-2005

The Jackson Laboratory
Associate research scientist/research scientist
1999-2004

Grants, Honors, and Accomplishments

NASA Certificate of Appreciation
Space Shuttle Endeavor STS-108
2001

School of Life Sciences Fellowship
University of Illinois
1986

Selected Publications

Highlighted Abstract

The vestibular system of the inner ear is responsible for the perception of motion and gravity. Key elements of this organ are otoconia, tiny biomineral particles in the utricle and the saccule. In response to gravity or linear acceleration, otoconia deflect the stereocilia of the hair cells, thus transducing kinetic movements into sensorineural action potentials. Here, we present an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3). This series of mutations identifies for the first time a protein with a clear enzymatic function as indispensable for otoconia morphogenesis.

View full list of publications

Tech CornerJuly 23, 2018
Developing better gene editing technology
New CRISPR technology will be used to more quickly develop mouse models for gastric cancer, Down syndrome and other applications.

Blog PostMarch 01, 2016
Collectively, rare diseases are not so rare
A team from The Jackson Laboratory attended a Rare Disease Day 2016 event in Maine to help educate state legislators and staff about the challenges of living with rare diseases, and how JAX is empowering the scientific and medical communities to combat these diseases.