Model organism development and evaluation for late-onset Alzheimer's Disease.
The AMP-AD Knowledge Portal is a platform to access data, analytical results and tools generated within the National Institute of Aging’s AD Translational Research Program....
Processes NGS alignments into a sparse compressed incidence matrix. Stores pre-defined binary format for efficient downstream analyses and storage.
PDXNet is an NCI-sponsored consortium that uses patient-derived xenografts to accelerate translational research for the broader research community. The Chuang lab has been...
The Mutant Mouse Resource and Research Center (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with...
The Jackson Laboratory maintains and distributes chromosome-aberration stocks that provide mouse models for Down syndrome, as well as the study of...
Phenotype and RNAseq data from approx. 200 (B6-Col4a5 KO x DO)F1 mice
For over half a century Oak Ridge National Laboratory generated and maintained a diverse collection of mouse stocks. A large part of this collection derived from induced...
Our specialized collection areas include: genetics, inbred mice, animal health and husbandry, development, embryology, complex traits, immunology, cancer, molecular biology,...
ATAC-seq is a new protocol to capture open chromatin sites by performing adaptor ligation and fragmentation of open chromatin regions. Due to its efficiency in requirement of...
NOD-scid IL2rgnull (NSG) and NOD-Rag1null IL2rgnull (NRG) mice support heightened levels of engraftment with human cells and tissues. These engrafted mice allow research on...
This tool calculates the glomerular filtration rate in mice using the FITC-inulin method
The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology database) integrates data on the frequency, incidence, genetics, and pathology of neoplastic...
sRACIPE is a systems-biology modeling method which takes the gene regulatory circuit topology as the only input, and simulates an ensemble of models with random kinetic...
CKB is a dynamic, digital encyclopedia for precision oncology that connects cancer variants to therapies, efficacy evidence, and clinical trials and aids interpretation of...
CloudNeo is a cloud-based computational workflow for identifying patient-specific tumor neoantigens from next generation sequencing data.
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases.
This resource provides mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial...
The MMR mouse variation database provides access to all genetic variants called from high-throughput exome and whole genome sequencing from mice exhibiting spontaneously...
Gene Expression Database (GXD) is a database project that integrates different types of gene expression information from the mouse and provides a searchable index of...
Mouse Genome Database (MGD) is a core knowledgebase for the laboratory mouse and is focused on providing integrated genetic, genomic, and biological data to facilitate the...
This resource is a collaborative standardized collection of measured data on laboratory mouse strains and populations. Includes baseline phenotype data sets as well as...
Tools for automatic glomerulus identification and histological quantification from scanned PAS slides
Visualize and interrogate gene expression changes in glaucoma
The Parkinson’s Disease Mouse Model Resource characterizes and distributes new mouse models of Parkinsonism and Parkinson’s disease.
An expectation maximization algorithm for allele specific expression. Primary author K. Choi of the Churchill Lab.
Describes mouse models for ocular research available at The Jackson Laboratory and provides a list of known mouse mutations that affect vision.
PDX Finder is an open global cancer research portal to patient derived xenograft (PDX) models.
Based on integrated analysis of paired-end RNA sequencing and DNA copy number data from The Cancer Genome Atlas(TCGA), The Tumor Fusion Gene Data...
FusorSV is a data mining-based framework that allows for comprehensive and robust detection of Structural Variations (SV) from next generation sequencing datasets. We built...
Genome Editing tools. Creates custom genomes by incorporating (phased) SNPs and indels into reference genome, extracts regions of interest, e.g., exons or transcripts, from...
Genotype-free genome reconstruction and ASE quantification.
Genetic Resource Science initiates and develops resource-generating research. Our team: identifies and implements innovative technologies for genetic research; makes and...
GeneWeaver is a platform for the integrative analysis of heterogeneous functional genomics data. It allows users to compare and contrast biological functions across multiple...
Explore and compare multiple annotated mouse genomes.
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
The Human Phenotype Ontology (HPO) provides a standardized vocabulary of phenotypic abnormalities encountered in human disease.
Tool to quantify images where meaningful differences are discernible by eye, but difficult to quantify using traditional methods.
The International Mouse Strain Resource offers users a combined catalog of worldwide mouse resources (live, cryopreserved, and embryonic stem cells), with direct access to...
An R package for eQTL/pQTL mediation analysis.
Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse...
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. The Mouse Mutant Resource...
The SMSR maintains mice that are important tools for genetic analysis of complex diseases, including consomic strains.
MouseMine is a powerful data warehouse providing comprehensive API (application programming interface) access to MGI data, as well as a forms-based...
We offer a growing number of mouse lines expressing proteins that activate, inhibit or detect neuronal activity.
Interactive web-based analysis tool that will allow users to replicate analyses reported for a study.
SARNAclust is a novel semi-automatic algorithm to identify RNA-protein binding motifs from immunoprecipitation data.
The WORM Human OrthoLogy Explorer is a meta-tool that uses machine learning to predict novel least diverged orthologs (LDOs) by integrating ortholog predictions from 17...