Resource and model development
We develop models for basic research, tools for exploring disease mechanisms on a molecular level and precision models of human disease, to aid in our own research and in response to the needs of the global research community.
We have the capacity, facilities and expertise to initiate and execute large resource-generation programs with international impact. Our capabilities for integrating sequencing data, genome-editing technologies and mouse production and phenotyping platforms make us an ideal partner for both large and small projects.
We combine extensive knowledge of mouse genetics with sophisticated technologies to produce cutting-edge research resources. For example, we are partners in an international effort to develop a full library of knockout mice and annotated gene information. As one of three KOMP2 centers, we are generating over 800 knockout strains, assuring the genetic quality, and evaluating the viability and fecundity of each.
Our tool-development program is generating Cre-driver strains for research on specific diseases and characterizing both our own Cre-driver strains and those imported from other scientists, to give researchers the information to select the best strains for their work. Another program is using ES cell derivation technologies to develop new tools for both gene targeting and in vitro disease modeling.
We develop models from naturally occurring spontaneous mutations, ENU mutagenesis projects and gene targeting. Our team uses traditional and emergent techniques such as CRISPR to develop models for monogenic studies as well as complex multigenic diseases. Projects currently under way focus on causative gene discovery, craniofacial development, cancer, neurodegenerative diseases, and rare diseases, such as spinal muscular atrophy.
Our model development program focuses on collaborating with other scientists to develop models that can be made publicly available, license-free, for particular diseases or research areas where there is a significant need for new models.
Mouse model information
Laboratory mouse strains provide powerful tools to study genetic disorders and normal traits. Mouse strains would be of little value, however, without information about their biological and genetic characteristics and their uses.
A team of Genetic Resource Science curators identifies, compiles and verifies strain information for all mice at The Jackson Laboratory. Our data curation enables users to search for JAX®Mice by disease, disease models, strain type, genes and mutant alleles.
We also collaborate closely with other scientists to develop and maintain valuable mouse information resources, such as Mouse Genome Informatics, Cre portal and International Mouse Phenotyping Consortium database.