JAX Center for Alzheimer's and Dementia Research

Living The Longest Day

In what has become an annual event, our team set out across Maine's Mount Desert Island to participate in The Longest Day and raise funds for the Alzheimer's Association.

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Finding ways to TREAT Alzheimer's disease

The quest to find a cure for Alzheimer’s disease (AD) has almost entirely met with failure at the clinical trial stage. Nonetheless, there have been research advances, particularly during the last few years, that are laying the foundation for progress in the years ahead.

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Alzheimer’s disease, microglia and genetic diversity

Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease.

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The JAX Center for Alzheimer’s and Dementia Research focusses on the origins, progression, and treatments of Alzheimer’s disease and related dementias using the mouse as a model organism.

Support Our Research

The JAX AD center aims to develop a truly integrated approach to studying AD that includes:

  • Multi-scale comparative analyses that rigorously test mouse-to-human alignment across diverse data modalities and layers of biological function;
  • Innovative technologies – both experimental and computational – that are designed to fully exploit the experimental tractability of model systems to better understand gene-by-environment interactions on disease outcomes;
  • Broad and uniform experimental designs to identify common functional mechanisms that underlie multiple diseases and comorbidities;
  • Expanded clinical and experimental study frameworks that include cognitive reserve, resistance to pathology, and resilience to clinical symptoms of neurodegenerative dementias.

Through these efforts, our goal is to nucleate a new synthesis of experimental and observational resources to generate advanced translational science.

Faculty & Staff

Gregory Carter, Ph.D. Professor

Gregory Carter, Ph.D.

Gareth Howell, Ph.D. Professor

Gareth Howell, Ph.D.

Kristen M.S. O'Connell, Ph.D. Associate Professor

Kristen M.S. O'Connell, Ph.D.

Michael Sasner, Ph.D. Research Scientist

Michael Sasner, Ph.D.

Upcoming Education

May 06 - 10
Hybrid Event

Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research

Jun 27 - 28
Workshop

Systems Immunology in Aging and Complex Diseases

Jul Aug 22 - 02
Short Course

Human and Mammalian Genetics and Genomics: The 65th McKusick Short Course

Precision medicine, Ethics, Stem cells, Microbiome, Infectious Disease, Immunology, Model Development, Rare Diseases, Aging, Cardiovascular, Cancer/Tumors, Developmental Biology, Diabetes, Genetic Tools, Optogenetics and Pharmacogenetics, Autoimmunity, Inflammation, Lupus, Addiction, Dermatology, Autoimmune Diseases Information, Metabolic Diseases, Neurodegenerative Disease, Reproductive Biology, Down Syndrome, Fragile X, Rett Syndrome, Neurodevelopmental Defects, Metabolic Defects, Cystic Fibrosis, Genetics and Genomics, Reproductive Disorders, Complex Traits, Developmental Disorders, Diabetes and Obesity, Neurodegenerative and Neuromuscular Diseases, Immune Disorders, Bioinformatics, Computational Biology, Cancer
Oct 08 - 10
Workshop

Workshop on Vascular Catheterization in the Laboratory Mouse

Model Development, Genetic Tools, Genetics and Genomics, Resource Development and Dissemination

Online Courses and On-Demand Webinars

Workshop

19th Annual Workshop on the Pathology of Mouse Models for Human Disease - Canceled

Model Development, Stem cells, Aging, Autoimmune Diseases Information, Bones and Joints, Dermatology, Cancer/Tumors, Digestion, Resource Development and Dissemination, Aging