The JAX AD center aims to develop a truly integrated approach to studying AD that includes:
- Multi-scale comparative analyses that rigorously test mouse-to-human alignment across diverse data modalities and layers of biological function;
- Innovative technologies – both experimental and computational – that are designed to fully exploit the experimental tractability of model systems to better understand gene-by-environment interactions on disease outcomes;
- Broad and uniform experimental designs to identify common functional mechanisms that underlie multiple diseases and comorbidities;
- Expanded clinical and experimental study frameworks that include cognitive reserve, resistance to pathology, and resilience to clinical symptoms of neurodegenerative dementias.
Through these efforts, our goal is to nucleate a new synthesis of experimental and observational resources to generate advanced translational science.