JAX Center for Alzheimer's and Dementia Research

The JAX Center for Alzheimer’s and Dementia Research focusses on the origins, progression, and treatments of Alzheimer’s disease and related dementias using the mouse as a model organism.

The JAX AD center aims to develop a truly integrated approach to studying AD that includes:

  • Multi-scale comparative analyses that rigorously test mouse-to-human alignment across diverse data modalities and layers of biological function;
  • Innovative technologies – both experimental and computational – that are designed to fully exploit the experimental tractability of model systems to better understand gene-by-environment interactions on disease outcomes;
  • Broad and uniform experimental designs to identify common functional mechanisms that underlie multiple diseases and comorbidities;
  • Expanded clinical and experimental study frameworks that include cognitive reserve, resistance to pathology, and resilience to clinical symptoms of neurodegenerative dementias.

Through these efforts, our goal is to nucleate a new synthesis of experimental and observational resources to generate advanced translational science.