Jackson Laboratory

Model-AD Consortium

Model organism development and evaluation for late-onset Alzheimer's Disease.

The MODEL-AD consortium consisting of a Center at Indiana University School of Medicine, The Jackson Laboratory, Sage Bionetworks and the University of Pittsburgh School of Medicine, and a Center at the University of California Irvine has been established by the National Institute on Aging to:

Develop the next generation of in vivo AD models based on human data
Institute a standardized and rigorous process for characterization of animal models
Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
Establish guidelines for rigorous preclinical testing in animal models
Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development

News and Announcements

Leveraging Model & Data Resources to Advance Alzheimer’s and Dementia Discovery Program

Read at alz.org

Cornucopia: LOADs of New Mouse Models Available

Alzheimer’s researchers have long wished for better mouse models. That is now coming true. Scientists at the Jackson Laboratory in Bar Harbor, Maine, are cranking out numerous lines that express humanized Aβ and tau in combination …

Read at alzforum.org

Profile StoryJune 19, 2023
What happens to the brain after a stroke?
Mary Teena Joy investigates what happens to the brain after a stroke and how to enhance brain neural rewiring to improve recovery.
Press ReleaseFebruary 08, 2023
JAX hires first chief data science officer
Paul Flicek, D.Sc., joins JAX as its inaugural chief data science officer to build a global data science initiative.
- Genetic Tools
- Data Science
Research HighlightDecember 11, 2018
The unexpected advantages of outbred mice in research
Recently developed outbred mouse populations, such as the diversity outbred (DO) mice at The Jackson Laboratory (JAX), have created research options that parallel or even exceed human genetic diversity. Research with DO mice offers a full range of genetic diversity, and therefore more generalizability of responses across populations.
Tech CornerFebruary 20, 2018
How does 'big data' define you?
Embrace the complexity of a trillion-line Excel file.

Blog PostFebruary 27, 2023
Examining the power and potential of the Cube
A synopsis of what The Cube Initiative is at JAX and why it may have a marked impact on the bridge between research and clinical application.
Press ReleaseApril 13, 2021
Shriners Hospitals for Children and JAX announce research affiliation
A new research affiliation agreement between Shriners Hospitals for Children (SHC) and JAX will endeavor to gain a greater understanding of the genetic factors involved in cerebral palsy.
Search MagazineMarch 05, 2018
Developing new therapies for Alzheimer’s disease
Alzheimer’s disease is still poorly understood despite its huge costs and burden. Greg Carter is working at the intersection between patient and mouse research to develop accurate disease models and develop effective therapies.