Jackson Laboratory

Model-AD Consortium

Model organism development and evaluation for late-onset Alzheimer's Disease.

The MODEL-AD consortium consisting of a Center at Indiana University School of Medicine, The Jackson Laboratory, Sage Bionetworks and the University of Pittsburgh School of Medicine, and a Center at the University of California Irvine has been established by the National Institute on Aging to:

Develop the next generation of in vivo AD models based on human data
Institute a standardized and rigorous process for characterization of animal models
Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
Establish guidelines for rigorous preclinical testing in animal models
Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development

News and Announcements

Leveraging Model & Data Resources to Advance Alzheimer’s and Dementia Discovery Program

Read at alz.org

Cornucopia: LOADs of New Mouse Models Available

Alzheimer’s researchers have long wished for better mouse models. That is now coming true. Scientists at the Jackson Laboratory in Bar Harbor, Maine, are cranking out numerous lines that express humanized Aβ and tau in combination …

Read at alzforum.org

Media ReleaseJuly 24, 2024
Mouse model for Alzheimer’s research
Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research.
Press ReleaseMarch 11, 2024
JAX and LG AI Research partner to pioneer biomedical advancements
Two world-leading organizations are partnering to further expand AI capabilities in biomedical science and catalyze medical progress.
Press ReleaseDecember 19, 2023
JAX's 2023 achievements
JAX is celebrating important research breakthroughs, new faculty and leadership appointments, and crucial advancements in legislation.
Featured ArticleOctober 24, 2023
Applying AI and machine learning to complex research tasks
JAX researchers are at the forefront of developing and implementing AI-based technologies for a variety of research applications.

Media ReleaseJuly 24, 2024
New analysis - targeted Alzheimer’s research and drug discovery
Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer’s Disease in advance of the Alzheimer's Association International Conference, July 28
Research HighlightDecember 28, 2023
Gene Expression Database for Mouse Development named a Global Core Biodata Resource
The Gene Expression Database for Mouse Development has been named a Global Core Biodata Resource in the 2023 selection round.
Featured ArticleNovember 21, 2023
Advancing Alzheimer's disease research
To solve Alzheimer’s disease, JAX's Kristen O'Connell is working to understand the biological factors that cause it.
Research HighlightSeptember 27, 2023
Exploring how genetics affects Alzheimer's disease
A research team led by Assistant Professor Erik Bloss and Professor Gareth Howell, and including predoctoral associate Sarah Heuer, explores how different genetic contexts affect the impact of early-stage Alzheimer's disease on neuronal circuits.