Guide: Humanized Mice for Immuno-Oncology

NSG™ and NSG™-SGM3 mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.

In this guide you will find:

  • Evidence that humanized NSG™ and NSG™-SGM3 mice can support the growth of allogeneic human tumors
  • Human tumors respond to standard-of-care chemotherapeutics and to immune check-point inhibitors clinically proven to initiate cytotoxic activity towards the tumor
  • Tumor-bearing, humanized NSG™ and NSG™-SGM3 mice are a new and valuable preclinical testing platform for immuno-oncology

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