Oct 25 Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging

Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging

Location: The Jackson Laboratory, Bar Harbor ME

This intensive, 3.5-day, in-person, interdisciplinary conference incorporates sleep and circadian biology and focuses on genetics, genomics, and computational biology approaches within the fields of aging and Alzheimer’s disease.

In-person registration is closed. To sign-up to be notified when registration for the 2022 event opens click here.

A virtual option of this course has been introduced and more information can be found at www.jax.org/virtualsleep

Please contact the event organizer for more information

About

The fields of sleep/circadian biology and AD are turning in a new direction, using strategies that include genetic and biomarker studies in humans and model organisms such as the mouse. Research is converging on recent advances in genomic technologies (e.g., single-cell RNA-seq and epigenomics) that allow more precise description of molecular and cellular changes that occur as a function of age, sleep/circadian rhythm and AD progression.

Stay up-to-date on current practices by attending this annual, intensive, 3.5-day, in-person, interdisciplinary conference which incorporates sleep and circadian biology and focuses on genetics, genomics, and computational biology approaches!

This course is perfect for: graduate students, postdoctoral fellows, and junior and senior investigators from the fields of aging and Alzheimer's disease, neurodegeneration, genetics of sleep/circadian biology and computational biology.

This course will feature:

Morning seminars to introduce trainees to the fundamentals of sleep/circadian biology and advanced computational approaches in genetics and genomics.

Hands-on afternoon workshops focusing on 'omics' analyses, career development, grantsmanship and ethics.

Breaks and evening discussions for networking with faculty and participants.

An opportunity for participants to present short talks or participate in a poster session.

If you are not able to attend this course in-person you can attend a virtual option which has been introduced. More details and registration can be found at jax.org/virtualsleep

Research reported in this publication was supported by the National Institutes of Health and the National Institute on Aging under Award Number R13AG072861 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Schedule

Download full Schedule

October25

October26

October27

October28

11:00 AM

Day 1

Monday, October 25^th

7:00 – 8:00 am
Breakfast

8:00 – 8:45 am
Keynote Lecture: Molecular Mechanism of the Circadian Clock
Joseph Takahashi, Ph.D., UT Southwestern

8:45 – 9:30 am
A Mechanism for Sleep Fragmentation During Aging
Luis de Lecea, Ph.D., Stanford University

9:30 – 9:45 am
Break

9:45 – 10:30 am
Advanced Mouse Populations
Gary Churchill, Ph.D., The Jackson Laboratory

10:30 – 11:15am
GWAS for Chronotype and Sleep Traits
Richa Saxena, Ph.D., Massachusetts General Hospital

11:15 am – 12:00 pm
Genetics of Human Circadian Variation
Louis Ptacek, M.D., University of California, San Francisco

12:00 – 1:00 pm
Lunch

1:00 – 4:00 pm
Workshop: Basic and Advanced Methods of Analysis of Sleep and Circadian Data
Ketema Paul, Ph.D., University of California, Los Angeles
Kenneth P. Wright Jr., Ph.D., University of Colorado Boulder

4:00 – 6:00 pm
Break

6:00 – 7:00 pm
Dinner

7:00 – 8:30 pm
Evening Discussion

11:00 AM

Day 2

Tuesday, October 26^th

7:00 – 8:00 am
Breakfast

8:00 – 8:45 am
Influence of Circadian Clocks on Neurodegeneration
Erik Musiek, M.D., Ph.D., Washington University School of Medicine in St. Louis

8:45 – 9:30 am
Genetics of Alzheimer's Disease: Toward a Mechanistic Understanding of Disease
Alison Goate, D.Phil., Icahn School of Medicine at Mount Sinai

9:30 – 9:45 am
Break

9:45 – 10:30 am
Aligning New Mouse Models of Alzheimer's Disease with Human Studies
Gregory Carter, Ph.D., The Jackson Laboratory

10:30 – 11:15am
The MODEL-AD Consortium: Creating Improved Preclinical Models for LOAD
Gareth Howell, Ph.D., The Jackson Laboratory

11:15 am – 12:00 pm
Modeling Sleep Disruption in Genetically Diverse AD Mouse Models
Catherine Cook Kaczorowski, Ph.D., The Jackson Laboratory

12:00 – 1:00 pm
Lunch

1:00 – 2:00 pm
Workshop: Analysis of AD Relevant Behaviors in Mice
Zoë Bichler, Ph.D., The Jackson Laboratory

1:00 – 3:00 pm
Workshop: Online Resources for Integration of Human and Mouse Data
Richa Saxena, Ph.D., Massachusetts General Hospital

4:00 – 6:00 pm
Break

6:00 – 7:00 pm
Lobster Dinner

7:00 – 8:30 pm
Evening Discussion

11:00 AM

Day 3

Wednesday, October 27^th

7:00 – 8:00 am
Breakfast

8:00 – 8:45 am
Keynote Lecture: Systems Genetics of Sleep
Paul Franken, Ph.D., Universite de Lausanne

8:45 – 9:30 am
Tools to Decipher Biology at Single Cell Resolution
Paul Robson, Ph.D., The Jackson Laboratory

9:30 – 9:45 am
Break

9:45 – 10:30 am
Single Cell Approaches to Identify Reproducible Cell Type Changes in AD
Vilas Menon, Ph.D., Columbia University

10:30 – 11:15am
Insights from Clock Genomics
John Hogenesch, Ph.D., Cincinnati Children’s Hospital

11:15 am – 12:00 pm
Mining Multi-omics Data for Mechanistic Clues about Clocks and Sleep
Steve Brown, Ph.D., University of Zurich

12:00 – 1:00 pm
Lunch

1:00 –4:00 pm
Workshop: Systems Data Analysis + Genomics Analysis Methods (Single Cell and Bulk RNAseq Data Analysis)
Lucia Peixoto, Ph.D., Washington State University

4:00 – 6:00 pm
Break

6:00 – 7:00 pm
Dinner

7:00 – 8:30 pm
Evening Discussion

11:00 AM

Day 4

Thursday, October 28^th

7:00 – 8:00 am
Breakfast

8:00 – 8:45 am
Lecture
Anne Justice, MA, Ph.D., Geisinger

8:45 – 10:30 am
Poster Session

10:30 am
Course End

On-Campus

Lodging at JAX's Highseas Lodging center has reached capacity.

Off-Campus

Participants will be responsible for securing off-campus lodging and may refer to the Bar Harbor Chamber of Commerce website for a guide on hotels, motels, bed & breakfasts, and short-term rentals in the Bar Harbor area.

Meals will be provided by JAX’s campus dining services throughout the event. Participants staying off-campus may still partake in evening meals at Highseas. Please refer to the event schedule for more information.

Participants must adhere to Maine State travel, health and safety guidelines at the time of the event and use good judgement when arranging lodging. We recommend participants be familiar with their hotel’s cancellation policies prior to booking. The Jackson Laboratory is not responsible for lodging expenses or losses incurred due to the cancellation or rescheduling of an event.

Air

Bar Harbor is serviced by two airports:

Hancock County/Bar Harbor Airport (BHB) – 20 minutes away
Bangor International Airport (BGR) – 1hr 15 minutes away

Public transportation is not available from local airports. Please visit the Bar Harbor and Bangor airport services webpages for information on shuttles to and from Mount Desert Island. Rideshare options like Uber or Lyft are not commonly available.

Ground

Bar Harbor is approximately 5 hours by car from the greater Boston area. Rental cars are available from Hertz at either nearby airport. Additionally, there is a free Island Explorer bus system which can be used around the island and the national park.

Additional Area Information:

Bar Harbor Chamber of Commerce
Acadia National Park

Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging

Location: The Jackson Laboratory, Bar Harbor ME

About

Schedule

Speakers

Zoë Bichler, Ph.D.

The Jackson Laboratory

Gregory Carter, Ph.D.

The Jackson Laboratory

Gary Churchill, Ph.D.

The Jackson Laboratory

Alison Goate, D.Phil.

Icahn School of Medicine at Mount Sinai

John Hogenesch, Ph.D.

Cincinnati Children's Hospital

Gareth Howell, Ph.D.

The Jackson Laboratory

Anne E Justice, MA, Ph.D.

Geisinger

Luis de Lecea, Ph.D.

Stanford University

Vilas Menon, Ph.D.

Columbia University Irving Medical Center

Erik Musiek, M.D., Ph.D.

Washington University School of Medicine in St. Louis

Ketema Paul, Ph.D.

University of California, Los Angeles

Lucia Peixoto, Ph.D.

Washington University

Louis Ptacek, M.D.

University of California, San Francisco

Carmen Robinett, Ph.D.

The Jackson Laboratory

Paul Robson, Ph.D.

The Jackson Laboratory

Kenneth P. Wright Jr., Ph.D.

University of Colorado Boulder

Travel Information

On-Campus

Off-Campus

People

Paul Franken, Ph.D.

Universite de Lausanne

David Holtzman, M.D.

Washington University

Vivek Kumar, Ph.D.

The Jackson Laboratory

Allan I Pack, M.B.Ch.B., Ph.D., FRCP

University of Pennsylvania, Perelman School of Medicine

Richa Saxena, Ph.D.

Massachusetts General Hospital, Harvard Medical School

Joseph Takahashi, Ph.D.

UT Southwestern Medical Center

Gianluca Tosini, Ph.D.

Morehouse School of Medicine

Supporters

Funding for Courses & Workshops has been generously provided by:

Platinum Level Sponsors:

Gold Level Sponsors:

Silver Level Sponsors:

Bronze Level Sponsors:

Partnered With