The Wang Lab
The Wang Laboratory at The Jackson Laboratory for Genomic Medicine is interested in understanding gene regulatory mechanisms that regulate leukemia survival, differentiation and therapy response.
Overcoming Drug Resistance in Hematologic Malignancies
Drug resistance continues to be the main limiting factor to achieving cures in cancer patients. The Wang laboratory is interested in investigating both genetic and non-genetic mechanisms of therapy resistance in hematologic malignancies. Here we apply a broad range of genetic tools including CRISPR-Cas9 genetic screens to identify drug-gene interactions and multi-modal single-cell technologies to reveal cell intrinsic and extrinsic (i.e., immune microenvironment) mechanisms of resistance. Overall, these studies will provide a blueprint for clinically relevant biomarkers and developing new therapeutic strategies to overcome drug resistance in cancer.
Uncovering Genetic Dependencies in Myeloid Neoplasms
Acute myeloid leukemia (AML) is an aggressive hematological malignancy that accounts for 80% of acute leukemia cases in adults. Despite recent therapeutic advances, AML is still marked by a dismal prognosis. Our laboratory is interested in identifying new therapeutic targets for AML. Here we develop and apply CRISPR platforms to understand gene regulatory networks that govern leukemia survival and differentiation. Moreover, we are interested in applying CRISPR screening approaches to identify novel synthetic lethal interactions to tumor suppressor mutations found in hematologic malignancies.
Role of RNA binding Proteins in Leukemia
Considering the importance of RNA splicing in gene regulation, cancer cells can exploit alternative splicing through various mechanisms (i.e., RNA splicing, polyadenylation) to promote tumor growth. Our laboratory has previously identified several RNA-binding proteins (RBPs) that are critical for leukemia growth, differentiation, and modulate drug response. Therefore, a primary focus of the laboratory is to advance our understanding of RNA biology in cancer biology. Here we will use state-of-the-art technologies to functionally interrogate splicing-associated mechanisms in hematologic neoplasms.
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Press ReleaseMay 01, 2024Cancer patients gain important benefits from genome-matched treatments
A study from MCGI indicates that Maine cancer patients experienced better outcomes following genomic tumor testing to guide targeted therapy strategies; but a gap between testing and clinical delivery still exists. -
Featured ArticleApril 23, 2024Charles Lee receives honorary doctor of science degree from University of Alberta
Charles Lee awarded honorary doctor of science degree from the University of Alberta and will deliver the convocation address to Faculty of Science graduates. -
Research HighlightApril 03, 2024Making mice a more powerful research tool
A new protocol sets the stage for researchers to directly compare mouse and human cells, and readily incorporates genetic diversity into mouse-based research to more closely approximate human health conditions. -
Press ReleaseMarch 21, 2024Aubrey Watkins III appointed VP of Corporate Development
Industry leader and innovator will help advance JAX’s mission.
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Research HighlightApril 23, 2024Investigating age-related immune dysfunction in lung epithelial cells
With $13 million in renewed support, Karolina Palucka will further study how aging affects airway epithelial cells’ efficiency in combating viral infections. -
Featured ArticleApril 23, 2024Dan Cortes: gearing up for discovery
Dan Cortes multifaceted journey has led him to pioneering stem cell research within the Pera lab, where he explores the intricate genetic landscape underlying neurological diseases and disorders. -
Featured ArticleMarch 26, 2024Working to characterize the function of protein-coding genes in the mouse
Using KOMP2, JAX researchers have now generated and characterized more than 2,000 knockout mice, gaining important insights into mammalian genetics and potential health impacts. -
Featured ArticleMarch 14, 20242024 Paigen Fellowship recognizes postdoctoral talent
The Paigen Fellowship supports postdoctoral associate Abdulfatai Tijjani's humanistic approach to research.