Oncology
We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.
Name & Stock Number |
NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) |
NOD.Cg-PrkdcscidIl2rgtm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (013062) |
NOD.Cg-Rag1tm1MomIl2rgtm1Wjl/SzJ (007799) |
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Branded or common name | NSG™(branded name), NOD scid gamma | NSGS, NOD scid gamma Il3- GM-SF (NSG-SGM3) |
NRG, NOD Rag gamma |
Mature B cells | Absent | Absent |
Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages | Defective | Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Absent | Absent |
Irradiation tolerance | Low | Low | High |
Lymphoma incidence | Low | Low | Low |
Benefits |
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|
Considerations |
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References | Nicolini et al. 2004; Wunderlich et al. 2010; Billerbeck et al. 2015 |
Name & Stock Number |
NOD.Cg-Mcph1Tg(HLA-A2.1)1EngePrkdcscidIl2rgtm1Wjl/SzJ (009617)NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ (014570) |
NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101) 1Dmz Prkdcscid Il2rgtm1Wjl/GckRolyJ (012479)NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Doi Tg(HLA-DRB1)31Dmz/SzJ (017637) |
NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ (010636)NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ (023848) |
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Branded or common name |
HLA Class I-A2 Transgenics |
HLA Class II Transgenics | MHC Class I-null NSG™ |
Mature B cells | Absent | Absent | Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages |
Defective |
Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Negligible | Negligible |
Irradiation tolerance | Low | Low |
Low |
Lymphoma incidence | Low | Low | Low |
Benefits |
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|
|
Considerations |
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References | Shultz et al. 2010 | Covassin et al. 2011 | Covassin et al. 2013 |
Name & Stock Number |
NOD.Cg-Prkdcscid H2-Ab1em1Mvw H2-K1tm1BpeH2-D1tm1Bpe Il2rgtm1Wjl/SzJ (025216) |
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ (030890) |
NOD.Cg.KitW-41JTyr+PrkdcscidIl2rgtm1Wjl/ThomJ (026622) |
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Branded or common name | Class 1/Class 2 Knockout
MHC I/II KO |
NSG-IL15
IL-15 |
NBSGW |
Mature B cells | Absent | Absent | Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages |
Defective |
Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Negligible | Negligible |
Irradiation tolerance | Low | Low | Low |
Lymphoma incidence | Low | Low | Low |
Benefits |
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Considerations |
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Although irradiation is not required for stem cell engraftment, NBSGW mice likely share the same sensitivity to genotoxic agents as other NSG strains |
References | Brehm et al. 2018 | Brehm et al. 2018 | McIntosh et al. 2015 |
Name & Stock Number |
NOD.Cg-PrkdcscidIl2rgtm1WjlTg(SERPINA1*E342K)#Slcw/SzJ (028842) |
NOD.Cg-Tlr4lps-del Prkdcscid Il2rgtm1Wjl/SzJ (033704) |
---|---|---|
Branded or common name | NSG-PiZ | NSG-Tlr4 KO |
Mature B cells | Absent | Absent |
Mature T cells | Absent | Absent |
Dendritic cells | Defective | Defective |
Macrophages |
Defective |
Defective |
Natural killer cells | Absent | Absent |
Complement | Absent | Absent |
Leakiness | Negligible | Negligible |
Irradiation tolerance | Low | Low |
Lymphoma incidence | Low | Low |
Benefits |
|
|
Considerations |
|
|
References | Borel, et al. 2017 | Aryee, et al. 2019 |
We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.
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