Oncology
We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.
Name & Stock Number | NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) |
NOD.Cg-PrkdcscidIl2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (013062) |
NOD.Cg-Rag1tm1MomIl2rgtm1Wjl/SzJ (007799) |
NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Il2rgtm1Wjl/SzJ (009617)NOD.Cg-PrkdcscidIl2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ (014570) |
NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101) 1Dmz Prkdcscid Il2rgtm1Wjl/GckRolyJ (012479)NOD.Cg-PrkdcscidIl2rgtm1WjlH2-Ab1tm1Doi Tg(HLA-DRB1)31Dmz/SzJ (017637) |
NOD.Cg-B2mtm1UncPrkdcscidIl2rgtm1Wjl/SzJ (010636)NOD.Cg-PrkdcscidH2-K1tm1BpeH2-D1tm1BpeIl2rgtm1Wjl/SzJ (023848) |
NOD.Cg-PrkdcscidH2-Ab1em1MvwH2-K1tm1BpeH2-D1tm1BpeIl2rgtm1Wjl/SzJ (025216) |
NOD.Cg-PrkdcscidIl2rgtm1Wjl Tg(IL15)1Sz/SzJ (030890) |
NOD.Cg-KitW-41JTyr+PrkdcscidIl2rgtm1Wjl/ThomJ (026622) |
NOD.Cg-PrkdcscidIl2rgtm1Wjl Tg(SERPINA1*E342K)#Slcw/SzJ (028842) |
NOD.Cg-Tlr4lps-delPrkdcscidIl2rgtm1Wjl/SzJ (033704) |
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Branded or common name | NSG™(branded name), NOD scid gamma | NSGS, NOD scid gamma Il3- GM-SF (NSG-SGM3) | NRG, NOD Rag gamma |
HLA Class I-A2 Transgenics |
HLA Class II Transgenics | MHC Class I-null NSG™ | Class 1/Class 2 Knockout MHC I/II KO |
NSG-IL15 IL-15 |
NBSGW | NSG-PiZ | NSG-Tlr4 KO |
Mature B cells | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent |
Mature T cells | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective |
Macrophages | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective | Defective |
Natural killer cells | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent |
Complement | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent |
Leakiness | Negligible | Absent | Absent | Negligible | Negligible | Negligible | Negligible | Negligible | Negligible | Negligible | Negligible |
Irradiation tolerance | Low | Low | High | Low | Low | Low | Low | Low | Low | Low | Low |
Lymphoma incidence | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |
Benefits |
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Considerations |
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Although irradiation is not required for stem cell engraftment, NBSGW mice likely share the same sensitivity to genotoxic agents as other NSG strains |
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References |
Nicolini et al. 2004; |
Shultz et al. 2010 | Covassin et al. 2011 | Covassin et al. 2013 | Brehm et al. 2018 | Brehm et al. 2018 | McIntosh et al. 2015 | Borel, et al. 2017 | Aryee, et al. 2019 |
We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
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This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
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This in-person course is a modern survey of heredity, disease, genetics in experimental animals and humans, and molecular...