NSG™-SGM3
The triple transgenic NSG-SGM3 mice enable superior engraftment of myeloid and CD4+ T cell lineages and primary AML samples and are useful for immuno-oncology, immunology and infectious disease studies.
Name & Stock Number |
NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) |
NOD.Cg-PrkdcscidIl2rgtm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (013062) |
NOD.Cg-Rag1tm1MomIl2rgtm1Wjl/SzJ (007799) |
---|---|---|---|
Branded or common name | NSG™(branded name), NOD scid gamma | NSGS, NOD scid gamma Il3- GM-SF (NSG-SGM3) |
NRG, NOD Rag gamma |
Mature B cells | Absent | Absent |
Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages | Defective | Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Absent | Absent |
Irradiation tolerance | Low | Low | High |
Lymphoma incidence | Low | Low | Low |
Benefits |
|
|
|
Considerations |
|
|
|
References | Nicolini et al. 2004; Wunderlich et al. 2010; Billerbeck et al. 2015 |
Name & Stock Number |
NOD.Cg-Mcph1Tg(HLA-A2.1)1EngePrkdcscidIl2rgtm1Wjl/SzJ (009617)NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ (014570) |
NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101) 1Dmz Prkdcscid Il2rgtm1Wjl/GckRolyJ (012479)NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Doi Tg(HLA-DRB1)31Dmz/SzJ (017637) |
NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ (010636)NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ (023848) |
---|---|---|---|
Branded or common name |
HLA Class I-A2 Transgenics |
HLA Class II Transgenics | MHC Class I-null NSG™ |
Mature B cells | Absent | Absent | Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages |
Defective |
Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Negligible | Negligible |
Irradiation tolerance | Low | Low |
Low |
Lymphoma incidence | Low | Low | Low |
Benefits |
|
|
|
Considerations |
|
|
|
References | Shultz et al. 2010 | Covassin et al. 2011 | Covassin et al. 2013 |
Name & Stock Number |
NOD.Cg-Prkdcscid H2-Ab1em1Mvw H2-K1tm1BpeH2-D1tm1Bpe Il2rgtm1Wjl/SzJ (025216) |
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ (030890) |
NOD.Cg.KitW-41JTyr+PrkdcscidIl2rgtm1Wjl/ThomJ (026622) |
---|---|---|---|
Branded or common name | Class 1/Class 2 Knockout
MHC I/II KO |
NSG-IL15
IL-15 |
NBSGW |
Mature B cells | Absent | Absent | Absent |
Mature T cells | Absent | Absent | Absent |
Dendritic cells | Defective | Defective | Defective |
Macrophages |
Defective |
Defective | Defective |
Natural killer cells | Absent | Absent | Absent |
Complement | Absent | Absent | Absent |
Leakiness | Negligible | Negligible | Negligible |
Irradiation tolerance | Low | Low | Low |
Lymphoma incidence | Low | Low | Low |
Benefits |
|
|
|
Considerations |
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|
Although irradiation is not required for stem cell engraftment, NBSGW mice likely share the same sensitivity to genotoxic agents as other NSG strains |
References | Brehm et al. 2018 | Brehm et al. 2018 | McIntosh et al. 2015 |
Name & Stock Number |
NOD.Cg-PrkdcscidIl2rgtm1WjlTg(SERPINA1*E342K)#Slcw/SzJ (028842) |
NOD.Cg-Tlr4lps-del Prkdcscid Il2rgtm1Wjl/SzJ (033704) |
---|---|---|
Branded or common name | NSG-PiZ | NSG-Tlr4 KO |
Mature B cells | Absent | Absent |
Mature T cells | Absent | Absent |
Dendritic cells | Defective | Defective |
Macrophages |
Defective |
Defective |
Natural killer cells | Absent | Absent |
Complement | Absent | Absent |
Leakiness | Negligible | Negligible |
Irradiation tolerance | Low | Low |
Lymphoma incidence | Low | Low |
Benefits |
|
|
Considerations |
|
|
References | Borel, et al. 2017 | Aryee, et al. 2019 |
The triple transgenic NSG-SGM3 mice enable superior engraftment of myeloid and CD4+ T cell lineages and primary AML samples and are useful for immuno-oncology, immunology and infectious disease studies.
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