JAX Mouse Strain Datasheet - 013062

NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ

Stock No:: 013062 |; NSG-SGM3

Readily Available

Overview

Also Known As: NOD-scid IL2Rgnull-3/GM/SF, NSG-SGM3, NSGS

The triple transgenic NSG-SGM3 (NSGS) mice expressing human IL3, GM-CSF and SCF combine the features of the highly immunodeficient NOD scid gamma (NSG) mouse with cytokines that support the stable engraftment of myeloid lineages and regulatory T cell populations. As a result, these NSG-SGM3 mice allow superior engraftment of diverse hematopoietic lineages and primary AML samples than other models and are useful for immuno-oncology, immunology and infectious disease studies.

Donating Investigator

James C Mulloy, Cincinnati Children's Hospital Medical Center

Genetic overview

Genetic Background	Generation
	N12+N1F4pF3p (17-NOV-15)

Il2rg^tm1Wjl

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Il2rg	interleukin 2 receptor, gamma chain

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

View Genetics

Research Applications

Cancer Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Research Tools
Virology Research

View All Research Applications

Base Price

Starting at:

$245.00 Domestic price for male 3-week

View Price List

Volume Pricing Available!

for select shipping destinations

Click for Details

Details

Detailed Description

These mice contain three coinjected transgenes, human interleukin-3 (IL-3), human granulocyte/macrophage-stimulating factor (GM-CSF), and human Steel factor (SF) gene, each driven by a human cytomegalovirus promoter/enhancer sequence. These mice are maintained on the NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice (Stock No. 005557) background. These mice constitutively produce 2-4 ng/ml serum levels of human IL-3, GM-CSF, and SF. The Il2rg-/- specific NOD.SCID background supports human and murine hematopoietic cell engraftment, and suppresses human erythropoiesis, enhances human myelopoiesis, and reduces human B-lymphopoiesis in mice after transplant of bone marrow or liver cells.

View Flow Cytometry Characterization Data for Immunodeficient JAX Strains

Development

Three separate transgenes were designed each carrying either the human interleukin-3 (IL-3) gene, the human granulocyte/macrophage-stimulating factor (GM-CSF) gene, or human Steel factor (SF) gene. Expression of each gene is driven by a human cytomegalovirus promoter/enhancer sequence, and is followed by a human growth hormone cassette and a polyadenylation (polyA) sequence. The transgenes were microinjected into fertilized C57BL/6xC3H/HeN oocytes. The resulting founders, carrying all three transgenes (3GS) were backcrossed to BALB/c-scid/scid mice for several generations and subsequently backcrossed to NOD.CB17-Prkdc^scid mice for at least 11 generations. These mice were bred to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl mice, and were then interbred until all offspring were homozygous for 3GS and the IL2rg targeted mutation. Upon arrival at The Jackson Laboratory, transgenic mice were bred to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice (Stock No. 005557) for one generation to establish the colony. Thereafter, females homozygous for Prkdc^scid, homozygous for Il2rg^tm1Wjl and homozygous for the 3GS transgenes were bred with males homozygous for Prkdc^scid, hemizygous for the X-linked Il2rg^tm1Wjl and homozygous for the 3GS transgenes.

Expression Data

Expressed Gene	CSF2, colony stimulating factor 2, human
Expressed Gene	IL3, interleukin 3, human
Expressed Gene	KITLG, KIT ligand, human
Site of Expression

Control Suggestions

Additional Information

Considerations for Choosing Controls

Selected References

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice. Blood 117(11):3076-86. PubMed: 21252091 MGI: J:170510
Bryce PJ; Falahati R; Kenney LL; Leung J; Bebbington C; Tomasevic N; Krier RA; Hsu CL; Shultz LD; Greiner DL; Brehm MA. 2016. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol :. PubMed: 27139822 MGI: J:231799
Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain. Stem Cells Dev 25(7):530-41. PubMed: 26879149 MGI: J:230785
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. PubMed: 20686503 MGI: J:166359

View All References

Genetics

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Allele Name	targeted mutation 1, Warren J Leonard
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	CD132^-; IL2Rgamma^null; Il2rg^tm1Wjll; [KO]gammac; gammac^-; gc^-
Gene Symbol and Name	Il2rg, interleukin 2 receptor, gamma chain
Gene Synonym(s)	Ab2-183; CD132; CIDX; Cd132; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gammaC; gc
Site of Expression	Primarily lymphoid cells.
Strain of Origin	129S4/SvJae
Chromosome	X
Molecular Note	A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein.
Mutations Made By	Dr. Warren Leonard, NHLBI, NIH

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Symbol: Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Name	transgene insertion 1, CJ Eaves
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	3/GM/SF; SGM3; Tg(hSCF/hGM-CSF/hIL3
Gene Symbol and Name	Tg(CMV-IL3,CSF2,KITLG)1Eav, transgene insertion 1, CJ Eaves
Gene Synonym(s)	3/GM/SF
Promoter	CMV, cytomegalovirus, human
Expressed Gene	CSF2, colony stimulating factor 2, human
Expressed Gene	IL3, interleukin 3, human
Expressed Gene	KITLG, KIT ligand, human
Strain of Origin	(C57BL/6 x C3H/HeN)F1
Chromosome	UN
Molecular Note	cDNAs encoding human interleukin 3, colony stimulating factor 2 (granulocyte-macrophage) and kit ligand were independently ligated into expression cassettes in which the cDNA resides downstream of the cytomegalovirus (CMV) promoter/enhancer sequence and is followed by human growth factor intronic and polyadenylation sequences. A transgenic mouse that was shown by ELISA to have serum levels of all three growth factors at ng/ml levels was used to establish a line with the same phenotype.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Il2rg^tm1Wjl related

Cancer Research
- Growth Factors/Receptors/Cytokines
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Phenotype Information

Body Weight Information - JAX® Mice Strain - NOD.Cg-Prkdc^scidIl2rg^tm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ

References

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice. Blood 117(11):3076-86. PubMed: 21252091 MGI: J:170510
Bryce PJ; Falahati R; Kenney LL; Leung J; Bebbington C; Tomasevic N; Krier RA; Hsu CL; Shultz LD; Greiner DL; Brehm MA. 2016. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol :. PubMed: 27139822 MGI: J:231799
Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain. Stem Cells Dev 25(7):530-41. PubMed: 26879149 MGI: J:230785
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. PubMed: 20686503 MGI: J:166359

Additional - Il2rg^tm1Wjl related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models. Carcinogenesis 36(11):1440-51. PubMed: 26424750 MGI: J:226625
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. PubMed: 18688847 MGI: J:142410
Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes. PLoS One 6(6):e20169. PubMed: 21695116 MGI: J:174292
Al-Shami A; Spolski R; Kelly J; Fry T; Schwartzberg PL; Pandey A; Mackall CL; Leonard WJ. 2004. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 200(2):159-68. PubMed: 15263024 MGI: J:108209
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. PubMed: 22937164 MGI: J:191672
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo. Stem Cells 33(4):1200-12. PubMed: 25532725 MGI: J:224046
Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. PubMed: 20668220 MGI: J:163262
Arpke RW; Darabi R; Mader TL; Zhang Y; Toyama A; Lonetree CL; Nash N; Lowe DA; Perlingeiro RC; Kyba M. 2013. A New Immuno- Dystrophin-Deficient Model, the NSG-Mdx Mouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation. Stem Cells :. PubMed: 23606600 MGI: J:199729
Ashkar AA; Black GP; Wei Q; He H; Liang L; Head JR; Croy BA. 2003. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171(6):2937-44. PubMed: 12960317 MGI: J:85375
Aspord C; Tramcourt L; Leloup C; Molens JP; Leccia MT; Charles J; Plumas J. 2014. Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization. J Invest Dermatol 134(10):2551-61. PubMed: 24751730 MGI: J:214771
Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. PubMed: 22065769 MGI: J:180174
Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. PubMed: 23225891 MGI: J:190812
Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. PubMed: 23776508 MGI: J:204234
Barclay SL; Yang Y; Zhang S; Fong R; Barraza A; Nolta JA; Torbett BE; Abedi M; Bauer G; Anderson JS. 2015. Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells. Stem Cells 33(3):870-9. PubMed: 25524029 MGI: J:223977
Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. PubMed: 21266536 MGI: J:172780
Bayer AL; Lee JY; de la Barrera A; Surh CD; Malek TR. 2008. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 181(1):225-34. PubMed: 18566388 MGI: J:137409
Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. PubMed: 24263804 MGI: J:206976
Bertilaccio MT; Simonetti G; Dagklis A; Rocchi M; Rodriguez TV; Apollonio B; Mantovani A; Ponzoni M; Ghia P; Garlanda C; Caligaris-Cappio F; Muzio M. 2011. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 118(3):660-9. PubMed: 21652674 MGI: J:174861
Bezman NA; Chakraborty T; Bender T; Lanier LL. 2011. miR-150 regulates the development of NK and iNKT cells. J Exp Med 208(13):2717-31. PubMed: 22124110 MGI: J:179053
Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. PubMed: 23833235 MGI: J:205706
Blaisdell A; Crequer A; Columbus D; Daikoku T; Mittal K; Dey SK; Erlebacher A. 2015. Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. Cancer Cell 28(6):785-99. PubMed: 26678340 MGI: J:227408
Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. PubMed: 22890824 MGI: J:191833
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. PubMed: 20688981 MGI: J:167433
Bournazos S; Klein F; Pietzsch J; Seaman MS; Nussenzweig MC; Ravetch JV. 2014. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 158(6):1243-53. PubMed: 25215485 MGI: J:214949
Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. PubMed: 23376950 MGI: J:194546
Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. PubMed: 22246028 MGI: J:180273
Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. PubMed: 22048767 MGI: J:179700
Bruedigam C; Bagger FO; Heidel FH; Paine Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee E; Riyat S; Moore AS; Lock RB; Bullinger L; Hill GR; Armstrong SA; Williams DA; Lane SW. 2014. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell 15(6):775-90. PubMed: 25479751 MGI: J:223853
Bucher C; Koch L; Vogtenhuber C; Goren E; Munger M; Panoskaltsis-Mortari A; Sivakumar P; Blazar BR. 2009. IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 114(26):5375-84. PubMed: 19843883 MGI: J:155701
Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. PubMed: 17681665 MGI: J:126691
Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. PubMed: 23223360 MGI: J:194620
Bunker JJ; Flynn TM; Koval JC; Shaw DG; Meisel M; McDonald BD; Ishizuka IE; Dent AL; Wilson PC; Jabri B; Antonopoulos DA; Bendelac A. 2015. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity 43(3):541-53. PubMed: 26320660 MGI: J:233653
Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280-90. PubMed: 17182565 MGI: J:141932
Cao X; Shores EW; Hu-Li J; Anver MR; Kelsall BL; Russell SM; Drago J; Noguchi M; Grinberg A; Bloom ET; Paul WE; Katz SI; Love PE; Leonard WJ. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2(3):223-38. PubMed: 7697543 MGI: J:24117
Castiglioni A; Corna G; Rigamonti E; Basso V; Vezzoli M; Monno A; Almada AE; Mondino A; Wagers AJ; Manfredi AA; Rovere-Querini P. 2015. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS One 10(6):e0128094. PubMed: 26039259 MGI: J:237716
Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32(4):860-73. PubMed: 24715688 MGI: J:210438
Chappaz S; Finke D. 2010. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol 184(7):3562-9. PubMed: 20207995 MGI: J:160069
Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. PubMed: 20016601 MGI: J:155800
Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. PubMed: 24474774 MGI: J:206650
Cheng G; Yu A; Dee MJ; Malek TR. 2013. IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development. J Immunol 190(4):1567-75. PubMed: 23315074 MGI: J:193324
Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Hoglund P; Jacobsen SE; Sitnicka E. 2009. Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development. J Immunol 182(3):1460-8. PubMed: 19155493 MGI: J:144325
Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A 113(7):E854-63. PubMed: 26831077 MGI: J:230438
Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. PubMed: 23965627 MGI: J:205431
Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. PubMed: 21429805 MGI: J:173961
Choi S; Chen Z; Tang LH; Fang Y; Shin SJ; Panarelli NC; Chen YT; Li Y; Jiang X; Du YC. 2016. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun 7:10384. PubMed: 26785948 MGI: J:235886
Civenni G; Walter A; Kobert N; Mihic-Probst D; Zipser M; Belloni B; Seifert B; Moch H; Dummer R; van den Broek M; Sommer L. 2011. Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth. Cancer Res 71(8):3098-109. PubMed: 21393506 MGI: J:170990
Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res 76(23):6964-6974. PubMed: 27671674 MGI: J:237848
Clemente-Casares X; Blanco J; Ambalavanan P; Yamanouchi J; Singha S; Fandos C; Tsai S; Wang J; Garabatos N; Izquierdo C; Agrawal S; Keough MB; Yong VW; James E; Moore A; Yang Y; Stratmann T; Serra P; Santamaria P. 2016. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 530(7591):434-40. PubMed: 26886799 MGI: J:229667
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. PubMed: 23378057 MGI: J:196312
Constantinides MG; Gudjonson H; McDonald BD; Ishizuka IE; Verhoef PA; Dinner AR; Bendelac A. 2015. PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A 112(16):5123-8. PubMed: 25838284 MGI: J:220811
Constantinides MG; McDonald BD; Verhoef PA; Bendelac A. 2014. A committed precursor to innate lymphoid cells. Nature :. PubMed: 24509713 MGI: J:205609
Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. PubMed: 16582912 MGI: J:112393
Cosgun KN; Rahmig S; Mende N; Reinke S; Hauber I; Schafer C; Petzold A; Weisbach H; Heidkamp G; Purbojo A; Cesnjevar R; Platz A; Bornhauser M; Schmitz M; Dudziak D; Hauber J; Kirberg J; Waskow C. 2014. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 15(2):227-38. PubMed: 25017720 MGI: J:232320
Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. PubMed: 23869841 MGI: J:200896
Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. PubMed: 21985373 MGI: J:177904
Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. PubMed: 16954498 MGI: J:142178
Czuczman NM; Barth MJ; Gu J; Neppalli V; Mavis C; Frys SE; Hu Q; Liu S; Klener P; Vockova P; Czuczman MS; Hernandez-Ilizaliturri FJ. 2016. Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo. Blood 127(9):1128-37. PubMed: 26675347 MGI: J:232593
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease. Sci Transl Med 7(281):281ra42. PubMed: 25834108 MGI: J:234081
Dai C; Kayton NS; Shostak A; Poffenberger G; Cyphert HA; Aramandla R; Thompson C; Papagiannis IG; Emfinger C; Shiota M; Stafford JM; Greiner DL; Herrera PL; Shultz LD; Stein R; Powers AC. 2016. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest 126(5):1857-70. PubMed: 27064285 MGI: J:234937
Danner R; Chaudhari SN; Rosenberger J; Surls J; Richie TL; Brumeanu TD; Casares S. 2011. Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells. PLoS One 6(5):e19826. PubMed: 21611197 MGI: J:172588
Darabi R; Gehlbach K; Bachoo RM; Kamath S; Osawa M; Kamm KE; Kyba M; Perlingeiro RC. 2008. Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nat Med 14(2):134-43. PubMed: 18204461 MGI: J:133565
Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. PubMed: 23430111 MGI: J:196692
Davies E; Reid S; Medina MF; Lichty B; Ashkar AA. 2010. IL-15 has innate anti-tumor activity independent of NK and CD8 T cells. J Leukoc Biol 88(3):529-36. PubMed: 20538758 MGI: J:164922
Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. PubMed: 23896410 MGI: J:202360
Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. PubMed: 22593616 MGI: J:188965
Duerr CU; McCarthy CD; Mindt BC; Rubio M; Meli AP; Pothlichet J; Eva MM; Gauchat JF; Qureshi ST; Mazer BD; Mossman KL; Malo D; Gamero AM; Vidal SM; King IL; Sarfati M; Fritz JH. 2016. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat Immunol 17(1):65-75. PubMed: 26595887 MGI: J:234573
Dumont N; Boyer L; Emond H; Celebi-Saltik B; Pasha R; Bazin R; Mantovani D; Roy DC; Pineault N. 2014. Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors. Exp Hematol 42(9):741-752.e1. PubMed: 24793546 MGI: J:214003
Eidenschenk C; Crozat K; Krebs P; Arens R; Popkin D; Arnold CN; Blasius AL; Benedict CA; Moresco EM; Xia Y; Beutler B. 2010. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A :. PubMed: 20457904 MGI: J:159599
Eisenring M; vom Berg J; Kristiansen G; Saller E; Becher B. 2010. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8. PubMed: 20935648 MGI: J:166535
El Haddad N; Heathcote D; Moore R; Yang S; Azzi J; Mfarrej B; Atkinson M; Sayegh MH; Lee JS; Ashton-Rickardt PG; Abdi R. 2011. Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood 117(4):1176-83. PubMed: 21076046 MGI: J:168605
Elsegeiny W; Eddens T; Chen K; Kolls JK. 2015. Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia. Infect Immun 83(5):2043-52. PubMed: 25733518 MGI: J:229720
Endig J; Buitrago-Molina LE; Marhenke S; Reisinger F; Saborowski A; Schutt J; Limbourg F; Konecke C; Schreder A; Michael A; Misslitz AC; Healy ME; Geffers R; Clavel T; Haller D; Unger K; Finegold M; Weber A; Manns MP; Longerich T; Heikenwalder M; Vogel A. 2016. Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development. Cancer Cell 30(2):308-23. PubMed: 27478039 MGI: J:234911
Enquist IB; Good Z; Jubb AM; Fuh G; Wang X; Junttila MR; Jackson EL; Leong KG. 2014. Lymph node-independent liver metastasis in a model of metastatic colorectal cancer. Nat Commun 5:3530. PubMed: 24667486 MGI: J:210473
Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. PubMed: 22617213 MGI: J:185539
Farr AR; Wu W; Choi B; Cavalcoli JD; Laouar Y. 2014. CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells. Proc Natl Acad Sci U S A 111(35):12841-6. PubMed: 25143585 MGI: J:216401
Fattahi F; Steinbeck JA; Kriks S; Tchieu J; Zimmer B; Kishinevsky S; Zeltner N; Mica Y; El-Nachef W; Zhao H; de Stanchina E; Gershon MD; Grikscheit TC; Chen S; Studer L. 2016. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature 531(7592):105-9. PubMed: 26863197 MGI: J:229669
Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. PubMed: 17082625 MGI: J:140483
Feng M; Chen JY; Weissman-Tsukamoto R; Volkmer JP; Ho PY; McKenna KM; Cheshier S; Zhang M; Guo N; Gip P; Mitra SS; Weissman IL. 2015. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A 112(7):2145-50. PubMed: 25646432 MGI: J:220007
Fiorini E; Ferrero I; Merck E; Favre S; Pierres M; Luther SA; MacDonald HR. 2008. Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. J Immunol 181(12):8199-203. PubMed: 19050235 MGI: J:142081
Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. PubMed: 23467088 MGI: J:194916
Font-Burgada J; Shalapour S; Ramaswamy S; Hsueh B; Rossell D; Umemura A; Taniguchi K; Nakagawa H; Valasek MA; Ye L; Kopp JL; Sander M; Carter H; Deisseroth K; Verma IM; Karin M. 2015. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell 162(4):766-79. PubMed: 26276631 MGI: J:224826
Fontenot JD; Rasmussen JP; Gavin MA; Rudensky AY. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6(11):1142-51. PubMed: 16227984 MGI: J:112602
Friedline RH; Ko HJ; Jung DY; Lee Y; Bortell R; Dagdeviren S; Patel PR; Hu X; Inashima K; Kearns C; Tsitsilianos N; Shafiq U; Shultz LD; Lee KW; Greiner DL; Kim JK. 2016. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J 30(3):1328-38. PubMed: 26644351 MGI: J:230896
Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. PubMed: 20729912 MGI: J:166563
Gan Y; Liu Q; Wu W; Yin JX; Bai XF; Shen R; Wang Y; Chen J; La Cava A; Poursine-Laurent J; Yokoyama W; Shi FD. 2014. Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proc Natl Acad Sci U S A 111(7):2704-9. PubMed: 24550298 MGI: J:206801
Gill N; Rosenthal KL; Ashkar AA. 2005. NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J Virol 79(7):4470-8. PubMed: 15767447 MGI: J:97038
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. PubMed: 20671189 MGI: J:162606
Gomez Perdiguero E; Klapproth K; Schulz C; Busch K; Azzoni E; Crozet L; Garner H; Trouillet C; de Bruijn MF; Geissmann F; Rodewald HR. 2015. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518(7540):547-51. PubMed: 25470051 MGI: J:219492
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. PubMed: 20495069 MGI: J:161304
Griffin RL; Kupper TS; Divito SJ. 2015. Humanized Mice in Dermatology Research. J Invest Dermatol 135(12):e39. PubMed: 26569593 MGI: J:228055
Guan J; Miah SM; Wilson ZS; Erick TK; Banh C; Brossay L. 2014. Role of type I interferon receptor signaling on NK cell development and functions. PLoS One 9(10):e111302. PubMed: 25333658 MGI: J:222452
Guimond M; Leonard WJ; Spolski R; Rossi SW; Veenstra RG; Hollander GA; Mackall CL; Blazar BR. 2008. Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood 111(2):969-70. PubMed: 18182587 MGI: J:130979
Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. PubMed: 19136960 MGI: J:144504
Gundry MC; Brunetti L; Lin A; Mayle AE; Kitano A; Wagner D; Hsu JI; Hoegenauer KA; Rooney CM; Goodell MA; Nakada D. 2016. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep 17(5):1453-1461. PubMed: 27783956 MGI: J:240901
Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. PubMed: 11696590 MGI: J:119138
Haddad G; Zhabyeyev P; Farhan M; Zhu LF; Kassiri Z; Rayner DC; Vanhaesebroeck B; Oudit GY; Murray AG. 2014. Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy. Blood 124(13):2142-9. PubMed: 25139353 MGI: J:214815
Haetscher N; Feuermann Y; Wingert S; Rehage M; Thalheimer FB; Weiser C; Bohnenberger H; Jung K; Schroeder T; Serve H; Oellerich T; Hennighausen L; Rieger MA. 2015. STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nat Commun 6:8928. PubMed: 26603207 MGI: J:228007
Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. PubMed: 23925295 MGI: J:201617
Hao J; Shi FD; Abdelwahab M; Shi SX; Simard A; Whiteaker P; Lukas R; Zhou Q. 2013. Nicotinic receptor beta2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. PLoS One 8(2):e57495. PubMed: 23469004 MGI: J:197263
Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. PubMed: 22464800 MGI: J:189339
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. PubMed: 20068223 MGI: J:162612
Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. PubMed: 19324903 MGI: J:148898
Holland JD; Gyorffy B; Vogel R; Eckert K; Valenti G; Fang L; Lohneis P; Elezkurtaj S; Ziebold U; Birchmeier W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep 5(5):1214-27. PubMed: 24290754 MGI: J:206839
Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. PubMed: 22343031 MGI: J:184937
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. PubMed: 20601939 MGI: J:162607
Howitt MR; Lavoie S; Michaud M; Blum AM; Tran SV; Weinstock JV; Gallini CA; Redding K; Margolskee RF; Osborne LC; Artis D; Garrett WS. 2016. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351(6279):1329-33. PubMed: 26847546 MGI: J:231305
Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. PubMed: 21926352 MGI: J:178783
Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. PubMed: 22753496 MGI: J:186492
Imtiyaz HZ; Zhou X; Zhang H; Chen D; Hu T; Zhang J. 2009. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation. J Biol Chem 284(15):9917-26. PubMed: 19203997 MGI: J:149068
Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. PubMed: 22558161 MGI: J:187283
Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. PubMed: 15920010 MGI: J:142411
Jahchan NS; Lim JS; Bola B; Morris K; Seitz G; Tran KQ; Xu L; Trapani F; Morrow CJ; Cristea S; Coles GL; Yang D; Vaka D; Kareta MS; George J; Mazur PK; Nguyen T; Anderson WC; Dylla SJ; Blackhall F; Peifer M; Dive C; Sage J. 2016. Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer. Cell Rep 16(3):644-56. PubMed: 27373157 MGI: J:238584
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. PubMed: 19802382 MGI: J:154110
Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. PubMed: 20072130 MGI: J:162611
Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. PubMed: 20505160 MGI: J:163485
Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. PubMed: 18852293 MGI: J:141103
Jurczyk A; Nowosielska A; Przewozniak N; Aryee KE; DiIorio P; Blodgett D; Yang C; Campbell-Thompson M; Atkinson M; Shultz L; Rittenhouse A; Harlan D; Greiner D; Bortell R. 2016. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic beta-cell function via glycogen synthase kinase-3beta. FASEB J 30(2):983-93. PubMed: 26546129 MGI: J:230840
Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. PubMed: 19006696 MGI: J:142395
Karst AM; Levanon K; Drapkin R. 2011. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A 108(18):7547-52. PubMed: 21502498 MGI: J:172047
Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. PubMed: 22897850 MGI: J:191823
Kelly J; Spolski R; Imada K; Bollenbacher J; Lee S; Leonard WJ. 2003. A role for stat5 in CD8(+) T cell homeostasis. J Immunol 170(1):210-7. PubMed: 12496402 MGI: J:80897
Kim HJ; Verbinnen B; Tang X; Lu L; Cantor H. 2010. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 467(7313):328-32. PubMed: 20844537 MGI: J:164663
Kim HY; Lee HJ; Chang YJ; Pichavant M; Shore SA; Fitzgerald KA; Iwakura Y; Israel E; Bolger K; Faul J; DeKruyff RH; Umetsu DT. 2014. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med 20(1):54-61. PubMed: 24336249 MGI: J:226577
Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. PubMed: 21873530 MGI: J:179333
Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. PubMed: 23300950 MGI: J:195822
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. PubMed: 19659776 MGI: J:151390
Kinkel SA; Galeev R; Flensburg C; Keniry A; Breslin K; Gilan O; Lee S; Liu J; Chen K; Gearing LJ; Moore DL; Alexander WS; Dawson M; Majewski IJ; Oshlack A; Larsson J; Blewitt ME. 2015. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood 125(12):1890-900. PubMed: 25645357 MGI: J:222052
Klose CS; Kiss EA; Schwierzeck V; Ebert K; Hoyler T; d'Hargues Y; Goppert N; Croxford AL; Waisman A; Tanriver Y; Diefenbach A. 2013. A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature 494(7436):261-5. PubMed: 23334414 MGI: J:194555
Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. PubMed: 24209604 MGI: J:206743
Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. PubMed: 22664870 MGI: J:188934
Krueger A; von Boehmer H. 2007. Identification of a T lineage-committed progenitor in adult blood. Immunity 26(1):105-16. PubMed: 17222572 MGI: J:118201
Ksander BR; Kolovou PE; Wilson BJ; Saab KR; Guo Q; Ma J; McGuire SP; Gregory MS; Vincent WJ; Perez VL; Cruz-Guilloty F; Kao WW; Call MK; Tucker BA; Zhan Q; Murphy GF; Lathrop KL; Alt C; Mortensen LJ; Lin CP; Zieske JD; Frank MH; Frank NY. 2014. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature 511(7509):353-7. PubMed: 25030174 MGI: J:213708
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. PubMed: 18691745 MGI: J:142409
Kuroda-Morimoto M; Tanaka H; Hayashi N; Nakahira M; Imai Y; Imamura M; Yasuda K; Yumikura-Futatsugi S; Matsui K; Nakashima T; Sugimura K; Tsutsui H; Sano H; Nakanishi K. 2010. Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. Int Immunol 22(7):561-70. PubMed: 20497957 MGI: J:161302
Law KM; Komarova NL; Yewdall AW; Lee RK; Herrera OL; Wodarz D; Chen BK. 2016. In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection. Cell Rep 15(12):2771-83. PubMed: 27292632 MGI: J:238305
Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. PubMed: 23686485 MGI: J:204842
Li L; Wang L; Li L; Wang Z; Ho Y; McDonald T; Holyoake TL; Chen W; Bhatia R. 2012. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib. Cancer Cell 21(2):266-81. PubMed: 22340598 MGI: J:181458
Li S; Ling C; Zhong L; Li M; Su Q; He R; Tang Q; Greiner DL; Shultz LD; Brehm MA; Flotte TR; Mueller C; Srivastava A; Gao G. 2015. Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors. Mol Ther 23(12):1867-76. PubMed: 26403887 MGI: J:230567
Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. PubMed: 20713716 MGI: J:163745
Liu Q; Sanai N; Jin WN; La Cava A; Van Kaer L; Shi FD. 2016. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci 19(2):243-52. PubMed: 26752157 MGI: J:234432
Liu R; Liu C; Chen D; Yang WH; Liu X; Liu CG; Dugas CM; Tang F; Zheng P; Liu Y; Wang L. 2015. FOXP3 Controls an miR-146/NF-kappaB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. Cancer Res 75(8):1703-13. PubMed: 25712342 MGI: J:220159
Long AH; Haso WM; Shern JF; Wanhainen KM; Murgai M; Ingaramo M; Smith JP; Walker AJ; Kohler ME; Venkateshwara VR; Kaplan RN; Patterson GH; Fry TJ; Orentas RJ; Mackall CL. 2015. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med 21(6):581-90. PubMed: 25939063 MGI: J:228468
Long BR; Stoddart CA. 2012. Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice. J Virol 86(6):3327-36. PubMed: 22238321 MGI: J:181199
Lu L; Ikizawa K; Hu D; Werneck MB; Wucherpfennig KW; Cantor H. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26(5):593-604. PubMed: 17509909 MGI: J:123555
Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. PubMed: 19481135 MGI: J:151435
Ma S; Shukla V; Fang L; Gould KA; Joshi SS; Lu R. 2013. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. J Biol Chem 288(37):26430-40. PubMed: 23897826 MGI: J:203533
Ma S; Turetsky A; Trinh L; Lu R. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J Immunol 177(11):7898-904. PubMed: 17114461 MGI: J:140693
Madera S; Rapp M; Firth MA; Beilke JN; Lanier LL; Sun JC. 2016. Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med 213(2):225-33. PubMed: 26755706 MGI: J:232648
Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. PubMed: 20472832 MGI: J:164541
Mahapatro M; Foersch S; Hefele M; He GW; Giner-Ventura E; Mchedlidze T; Kindermann M; Vetrano S; Danese S; Gunther C; Neurath MF; Wirtz S; Becker C. 2016. Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection. Cell Rep 15(8):1743-56. PubMed: 27184849 MGI: J:235754
Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. PubMed: 18371405 MGI: J:142413
Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. PubMed: 23659714 MGI: J:202643
Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. PubMed: 22072769 MGI: J:179389
Marsh SE; Abud EM; Lakatos A; Karimzadeh A; Yeung ST; Davtyan H; Fote GM; Lau L; Weinger JG; Lane TE; Inlay MA; Poon WW; Blurton-Jones M. 2016. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A 113(9):E1316-25. PubMed: 26884167 MGI: J:231007
Martinez-Forero I; Azpilikueta A; Bolanos-Mateo E; Nistal-Villan E; Palazon A; Teijeira A; Perez-Chacon G; Morales-Kastresana A; Murillo O; Jure-Kunkel M; Zapata JM; Melero I. 2013. T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J Immunol 190(12):6694-706. PubMed: 23690480 MGI: J:204832
Martins VC; Busch K; Juraeva D; Blum C; Ludwig C; Rasche V; Lasitschka F; Mastitsky SE; Brors B; Hielscher T; Fehling HJ; Rodewald HR. 2014. Cell competition is a tumour suppressor mechanism in the thymus. Nature 509(7501):465-70. PubMed: 24828041 MGI: J:210588
Martins VC; Ruggiero E; Schlenner SM; Madan V; Schmidt M; Fink PJ; von Kalle C; Rodewald HR. 2012. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med 209(8):1409-17. PubMed: 22778389 MGI: J:189166
Masse GX; Corcuff E; Decaluwe H; Bommhardt U; Lantz O; Buer J; Di Santo JP. 2007. gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells. Eur J Immunol 37(9):2606-16. PubMed: 17683114 MGI: J:124346
Maykel J; Liu JH; Li H; Shultz LD; Greiner DL; Houghton J. 2014. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci 59(6):1169-79. PubMed: 24798995 MGI: J:227975
McCaughtry TM; Etzensperger R; Alag A; Tai X; Kurtulus S; Park JH; Grinberg A; Love P; Feigenbaum L; Erman B; Singer A. 2012. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209(12):2263-76. PubMed: 23109710 MGI: J:190889
McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. PubMed: 20404133 MGI: J:162809
McIntosh BE; Brown ME; Duffin BM; Maufort JP; Vereide DT; Slukvin II; Thomson JA. 2015. Nonirradiated NOD,B6.SCID Il2rgamma(-/-)Kit(W41/W41) (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells. Stem Cell Reports 4(2):171-80. PubMed: 25601207 MGI: J:218738
Merck E; Voyle RB; MacDonald HR. 2009. Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth. J Immunol 182(1):183-92. PubMed: 19109149 MGI: J:143041
Min-Oo G; Bezman NA; Madera S; Sun JC; Lanier LL. 2014. Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection. J Exp Med 211(7):1289-96. PubMed: 24958849 MGI: J:214519
Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. PubMed: 14688383 MGI: J:87075
Moro K; Yamada T; Tanabe M; Takeuchi T; Ikawa T; Kawamoto H; Furusawa J; Ohtani M; Fujii H; Koyasu S. 2010. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463(7280):540-4. PubMed: 20023630 MGI: J:156764
Morris SC; Orekhova T; Meadows MJ; Heidorn SM; Yang J; Finkelman FD. 2006. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176(9):5299-305. PubMed: 16621996 MGI: J:131660
Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. PubMed: 19535452 MGI: J:153922
Mukai K; Matsuoka K; Taya C; Suzuki H; Yokozeki H; Nishioka K; Hirokawa K; Etori M; Yamashita M; Kubota T; Minegishi Y; Yonekawa H; Karasuyama H. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23(2):191-202. PubMed: 16111637 MGI: J:100537
Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. PubMed: 22791816 MGI: J:192954
Nakajima H; Leonard WJ. 1999. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol 162(2):782-90. PubMed: 9916699 MGI: J:52019
Nakajima H; Leonard WJ. 1997. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice. J Immunol 159(10):4737-44. PubMed: 9366397 MGI: J:43962
Nakajima H; Shores EW; Noguchi M; Leonard WJ. 1997. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 185(2):189-95. PubMed: 9016868 MGI: J:107159
Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. PubMed: 20805496 MGI: J:164365
Nolte T; Zadeh-Khorasani M; Safarov O; Rueff F; Varga R; Herbach N; Wanke R; Wollenberg A; Mueller T; Gropp R; Wolf E; Siebeck M. 2013. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech 6(1):125-34. PubMed: 22822046 MGI: J:192789
Nozad Charoudeh H; Tang Y; Cheng M; Cilio CM; Jacobsen SE; Sitnicka E. 2010. Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood 116(2):183-92. PubMed: 20421450 MGI: J:162802
Nucera S; Giustacchini A; Boccalatte F; Calabria A; Fanciullo C; Plati T; Ranghetti A; Garcia-Manteiga J; Cittaro D; Benedicenti F; Lechman ER; Dick JE; Ponzoni M; Ciceri F; Montini E; Gentner B; Naldini L. 2016. miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia. Cancer Cell 29(6):905-21. PubMed: 27300437 MGI: J:232327
O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. PubMed: 22392992 MGI: J:182231
O'Leary JG; Goodarzi M; Drayton DL; von Andrian UH. 2006. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7(5):507-16. PubMed: 16617337 MGI: J:112596
O'Sullivan T; Saddawi-Konefka R; Vermi W; Koebel CM; Arthur C; White JM; Uppaluri R; Andrews DM; Ngiow SF; Teng MW; Smyth MJ; Schreiber RD; Bui JD. 2012. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med 209(10):1869-82. PubMed: 22927549 MGI: J:192935
Oberbarnscheidt MH; Zeng Q; Li Q; Dai H; Williams AL; Shlomchik WD; Rothstein DM; Lakkis FG. 2014. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 124(8):3579-89. PubMed: 24983319 MGI: J:213858
Ohteki T; Suzue K; Maki C; Ota T; Koyasu S. 2001. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol 2(12):1138-43. PubMed: 11702064 MGI: J:125660
Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. PubMed: 22430210 MGI: J:193369
Orr SJ; Roessler S; Quigley L; Chan T; Ford JW; O'Connor GM; McVicar DW. 2010. Implications for gene therapy-limiting expression of IL-2Rgammac delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol 185(3):1393-403. PubMed: 20592278 MGI: J:162459
Oruganti SR; Torres DJ; Krebsbach S; Asperti-Boursin F; Winters J; Matlawska-Wasowska K; Winter SS; Halsey C; Cannon JL. 2017. CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia 31(1):255-258. PubMed: 27698445 MGI: J:237842
Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. PubMed: 19447681 MGI: J:151452
Ozturk F; Li Y; Zhu X; Guda C; Nawshad A. 2013. Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFbeta3-knockout mice alleles: RNA-Seq analysis of TGFbeta3 Mice. BMC Genomics 14:113. PubMed: 23421592 MGI: J:196701
Park H; Tsang M; Iritani BM; Bevan MJ. 2014. Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A 111(19):7066-71. PubMed: 24785297 MGI: J:211065
Pathania R; Ramachandran S; Elangovan S; Padia R; Yang P; Cinghu S; Veeranan-Karmegam R; Arjunan P; Gnana-Prakasam JP; Sadanand F; Pei L; Chang CS; Choi JH; Shi H; Manicassamy S; Prasad PD; Sharma S; Ganapathy V; Jothi R; Thangaraju M. 2015. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. Nat Commun 6:6910. PubMed: 25908435 MGI: J:222799
Pathania R; Ramachandran S; Mariappan G; Thakur P; Shi H; Choi JH; Manicassamy S; Kolhe R; Prasad PD; Sharma S; Lokeshwar BL; Ganapathy V; Thangaraju M. 2016. Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth. Cancer Res 76(11):3224-35. PubMed: 27197203 MGI: J:232034
Paust S; Gill HS; Wang BZ; Flynn MP; Moseman EA; Senman B; Szczepanik M; Telenti A; Askenase PW; Compans RW; von Andrian UH. 2010. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 11(12):1127-35. PubMed: 20972432 MGI: J:167327
Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. PubMed: 18491294 MGI: J:151386
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. PubMed: 18563383 MGI: J:138005
Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. PubMed: 18785974 MGI: J:140388
Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. PubMed: 22340590 MGI: J:181463
Porcellini S; Traggiai E; Schenk U; Ferrera D; Matteoli M; Lanzavecchia A; Michalak M; Grassi F. 2006. Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-71. PubMed: 16492806 MGI: J:119147
Porter BO; Malek TR. 1999. IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development. J Immunol 163(11):5906-12. PubMed: 10570276 MGI: J:58655
Price AE; Liang HE; Sullivan BM; Reinhardt RL; Eisley CJ; Erle DJ; Locksley RM. 2010. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A 107(25):11489-94. PubMed: 20534524 MGI: J:161387
Purwana I; Zheng J; Li X; Deurloo M; Son DO; Zhang Z; Liang C; Shen E; Tadkase A; Feng ZP; Li Y; Hasilo C; Paraskevas S; Bortell R; Greiner DL; Atkinson M; Prud'homme GJ; Wang Q. 2014. GABA promotes human beta-cell proliferation and modulates glucose homeostasis. Diabetes 63(12):4197-205. PubMed: 25008178 MGI: J:230144
Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. PubMed: 23933255 MGI: J:201893
Quarmyne M; Doan PL; Himburg HA; Yan X; Nakamura M; Zhao L; Chao NJ; Chute JP. 2015. Protein tyrosine phosphatase-sigma regulates hematopoietic stem cell-repopulating capacity. J Clin Invest 125(1):177-82. PubMed: 25415437 MGI: J:219369
Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. PubMed: 19052619 MGI: J:142408
Ramirez-Carrozzi V; Sambandam A; Luis E; Lin Z; Jeet S; Lesch J; Hackney J; Kim J; Zhou M; Lai J; Modrusan Z; Sai T; Lee W; Xu M; Caplazi P; Diehl L; de Voss J; Balazs M; Gonzalez L Jr; Singh H; Ouyang W; Pappu R. 2011. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12(12):1159-66. PubMed: 21993848 MGI: J:178967
Ramsey C; Rubinstein MP; Kim DM; Cho JH; Sprent J; Surh CD. 2008. The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol 180(8):5320-6. PubMed: 18390713 MGI: J:134238
Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. PubMed: 22542847 MGI: J:184798
Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. PubMed: 21209895 MGI: J:168312
Robbiani DF; Deroubaix S; Feldhahn N; Oliveira TY; Callen E; Wang Q; Jankovic M; Silva IT; Rommel PC; Bosque D; Eisenreich T; Nussenzweig A; Nussenzweig MC. 2015. Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell 162(4):727-37. PubMed: 26276629 MGI: J:224827
Rodgers JT; King KY; Brett JO; Cromie MJ; Charville GW; Maguire KK; Brunson C; Mastey N; Liu L; Tsai CR; Goodell MA; Rando TA. 2014. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature 510(7505):393-6. PubMed: 24870234 MGI: J:213273
Rosenberger CM; Clark AE; Treuting PM; Johnson CD; Aderem A. 2008. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A 105(7):2544-9. PubMed: 18268321 MGI: J:132172
Rothfuchs AG; Trumstedt C; Wigzell H; Rottenberg ME. 2004. Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling. J Immunol 172(10):6345-53. PubMed: 15128825 MGI: J:89856
Roy N; Takeuchi KK; Ruggeri JM; Bailey P; Chang D; Li J; Leonhardt L; Puri S; Hoffman MT; Gao S; Halbrook CJ; Song Y; Ljungman M; Malik S; Wright CV; Dawson DW; Biankin AV; Hebrok M; Crawford HC. 2016. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev 30(24):2669-2683. PubMed: 28087712 MGI: J:238701
Sabet-Baktach M; Eggenhofer E; Rovira J; Renner P; Lantow M; Farkas SA; Malaise M; Edtinger K; Shaotang Z; Koehl GE; Dahlke MH; Schlitt HJ; Geissler EK; Kroemer A. 2013. Double deficiency for RORgammat and T-bet drives Th2-mediated allograft rejection in mice. J Immunol 191(8):4440-6. PubMed: 24058178 MGI: J:206252
Saddawi-Konefka R; Seelige R; Gross ET; Levy E; Searles SC; Washington A Jr; Santosa EK; Liu B; O'Sullivan TE; Harismendy O; Bui JD. 2016. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell Rep 16(9):2348-58. PubMed: 27545889 MGI: J:239033
Saint Fleur S; Hoshino A; Kondo K; Egawa T; Fujii H. 2009. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood 114(7):1355-65. PubMed: 19528538 MGI: J:151722
Saito A; Henning MS; Serrao E; Dubose BN; Teng S; Huang J; Li X; Saito N; Roy SP; Siddiqui MA; Ahn J; Tsuji M; Hatziioannou T; Engelman AN; Yamashita M. 2016. Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. J Virol 90(15):6918-35. PubMed: 27307565 MGI: J:234650
Sander S; Calado DP; Srinivasan L; Kochert K; Zhang B; Rosolowski M; Rodig SJ; Holzmann K; Stilgenbauer S; Siebert R; Bullinger L; Rajewsky K. 2012. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22(2):167-79. PubMed: 22897848 MGI: J:191824
Sandri S; Bobisse S; Moxley K; Lamolinara A; De Sanctis F; Boschi F; Sbarbati A; Fracasso G; Ferrarini G; Hendriks RW; Cavallini C; Scupoli MT; Sartoris S; Iezzi M; Nishimura MI; Bronte V; Ugel S. 2016. Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies. Cancer Res 76(9):2540-51. PubMed: 27197263 MGI: J:232028
Sanos SL; Bui VL; Mortha A; Oberle K; Heners C; Johner C; Diefenbach A. 2009. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 10(1):83-91. PubMed: 19029903 MGI: J:142348
Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol 16(12):1238-48. PubMed: 25362351 MGI: J:217693
Schroder PM; Khattar M; Baum CE; Miyahara Y; Chen W; Vyas R; Muralidharan S; Mierzejewska B; Stepkowski SM. 2015. PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRbeta mAb therapy. Diabetologia 58(6):1309-18. PubMed: 25794782 MGI: J:220839
Schwab I; Biburger M; Kronke G; Schett G; Nimmerjahn F. 2012. IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol 42(4):826-30. PubMed: 22278120 MGI: J:187786
Seehus CR; Aliahmad P; de la Torre B; Iliev ID; Spurka L; Funari VA; Kaye J. 2015. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol 16(6):599-608. PubMed: 25915732 MGI: J:232838
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. PubMed: 19636062 MGI: J:152910
Serafini N; Klein Wolterink RG; Satoh-Takayama N; Xu W; Vosshenrich CA; Hendriks RW; Di Santo JP. 2014. Gata3 drives development of RORgammat+ group 3 innate lymphoid cells. J Exp Med 211(2):199-208. PubMed: 24419270 MGI: J:208346
Sewald X; Ladinsky MS; Uchil PD; Beloor J; Pi R; Herrmann C; Motamedi N; Murooka TT; Brehm MA; Greiner DL; Shultz LD; Mempel TR; Bjorkman PJ; Kumar P; Mothes W. 2015. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science 350(6260):563-7. PubMed: 26429886 MGI: J:226540
Shang L; Hua H; Foo K; Martinez H; Watanabe K; Zimmer M; Kahler DJ; Freeby M; Chung W; LeDuc C; Goland R; Leibel RL; Egli D. 2014. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63(3):923-33. PubMed: 24227685 MGI: J:208989
Shukla A; Rai K; Shukla V; Chaturvedi NK; Bociek RG; Pirruccello SJ; Band H; Lu R; Joshi SS. 2016. Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL. Blood 127(19):2310-21. PubMed: 26809508 MGI: J:232635
Shukla V; Ma S; Hardy RR; Joshi SS; Lu R. 2013. A role for IRF4 in the development of CLL. Blood 122(16):2848-55. PubMed: 23926303 MGI: J:203270
Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. PubMed: 17259968 MGI: J:142414
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. PubMed: 15879151 MGI: J:109833
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. PubMed: 20615947 MGI: J:162315
Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. PubMed: 18453623 MGI: J:142412
Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. PubMed: 22371883 MGI: J:183769
Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. PubMed: 23643966 MGI: J:202381
Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. PubMed: 20671122 MGI: J:167434
Strowig T; Gurer C; Ploss A; Liu YF; Arrey F; Sashihara J; Koo G; Rice CM; Young JW; Chadburn A; Cohen JI; Munz C. 2009. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 206(6):1423-34. PubMed: 19487422 MGI: J:149509
Suzuki K; Nakajima H; Saito Y; Saito T; Leonard WJ; Iwamoto I. 2000. Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. Int Immunol 12(2):123-32. PubMed: 10653847 MGI: J:60418
Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. PubMed: 20634377 MGI: J:165866
Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. PubMed: 22279057 MGI: J:180274
Takatori H; Kanno Y; Watford WT; Tato CM; Weiss G; Ivanov II; Littman DR; O'Shea JJ. 2009. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206(1):35-41. PubMed: 19114665 MGI: J:144034
Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. PubMed: 22611244 MGI: J:188959
Tanno T; Lim Y; Wang Q; Chesi M; Bergsagel PL; Matthews G; Johnstone RW; Ghosh N; Borrello I; Huff CA; Matsui W. 2014. Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells. Blood 123(5):725-33. PubMed: 24345755 MGI: J:208701
Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 209(11):2065-77. PubMed: 23071255 MGI: J:190897
Taylor RT; Lugering A; Newell KA; Williams IR. 2004. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol 173(12):7183-9. PubMed: 15585839 MGI: J:94865
The Jackson Laboratory. 2005. Information obtained from The Jackson Laboratory, Bar Harbor, ME Unpublished :. MGI: J:101977
Thomas MF; Abdul-Wajid S; Panduro M; Babiarz JE; Rajaram M; Woodruff P; Lanier LL; Heissmeyer V; Ansel KM. 2012. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood 120(1):130-42. PubMed: 22613798 MGI: J:189125
Thomas SY; Scanlon ST; Griewank KG; Constantinides MG; Savage AK; Barr KA; Meng F; Luster AD; Bendelac A. 2011. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med 208(6):1179-88. PubMed: 21624939 MGI: J:176822
Todorova D; Kim J; Hamzeinejad S; He J; Xu Y. 2016. Brief Report: Immune Microenvironment Determines the Immunogenicity of Induced Pluripotent Stem Cell Derivatives. Stem Cells 34(2):510-5. PubMed: 26439188 MGI: J:233079
Tolar J; Wang X; Braunlin E; McElmurry RT; Nakamura Y; Bell S; Xia L; Zhang J; Hu Q; Panoskaltsis-Mortari A; Zhang J; Blazar BR. 2007. The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia. Exp Hematol 35(4):682-90. PubMed: 17379078 MGI: J:123112
Torreggiani E; Matthews BG; Pejda S; Matic I; Horowitz MC; Grcevic D; Kalajzic I. 2013. Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts. PLoS One 8(9):e75204. PubMed: 24040401 MGI: J:207546
Touma M; Sun ZY; Clayton LK; Marissen WE; Kruisbeek AM; Wagner G; Reinherz EL. 2007. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol 178(6):3668-79. PubMed: 17339464 MGI: J:144281
Ueno S; Lu J; He J; Li A; Zhang X; Ritz J; Silberstein LE; Chai L. 2014. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol 42(4):307-316.e8. PubMed: 24463278 MGI: J:215705
Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. PubMed: 19369639 MGI: J:151270
Unzu C; Melero I; Morales-Kastresana A; Sampedro A; Serrano-Mendioroz I; Azpilikueta A; Ochoa MC; Dubrot J; Martinez-Anso E; Fontanellas A. 2014. Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One 9(1):e85432. PubMed: 24465560 MGI: J:212341
Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB. 2014. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26(1):33-47. PubMed: 24954133 MGI: J:213713
Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. PubMed: 18227350 MGI: J:134359
Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. PubMed: 21875955 MGI: J:177573
Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. PubMed: 20430958 MGI: J:162797
Wallington-Beddoe CT; Powell JA; Tong D; Pitson SM; Bradstock KF; Bendall LJ. 2014. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res 74(10):2803-15. PubMed: 24686171 MGI: J:212466
Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. PubMed: 24516154 MGI: J:206819
Waskow C; Bartels S; Schlenner SM; Costa C; Rodewald HR. 2007. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood 109(12):5363-70. PubMed: 17327401 MGI: J:145426
Wei C; Zeff R; Goldschneider I. 2000. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. J Immunol 164(4):1961-70. PubMed: 10657646 MGI: J:60331
Wei S; Kozono S; Kats L; Nechama M; Li W; Guarnerio J; Luo M; You MH; Yao Y; Kondo A; Hu H; Bozkurt G; Moerke NJ; Cao S; Reschke M; Chen CH; Rego EM; Lo-Coco F; Cantley LC; Lee TH; Wu H; Zhang Y; Pandolfi PP; Zhou XZ; Lu KP. 2015. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med 21(5):457-66. PubMed: 25849135 MGI: J:228245
White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. PubMed: 22406538 MGI: J:184554
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60(6):1726-33. PubMed: 21521873 MGI: J:177952
Wilhelm C; Hirota K; Stieglitz B; Van Snick J; Tolaini M; Lahl K; Sparwasser T; Helmby H; Stockinger B. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071-7. PubMed: 21983833 MGI: J:177640
Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123(3):1032-43. PubMed: 23454765 MGI: J:196378
Wu X; Kastin AJ; Hsuchou H; Pan W. 2010. The effects of IL2Rgamma knockout on depression and contextual memory. Behav Brain Res 213(2):319-22. PubMed: 20438766 MGI: J:161861
Wunderlich M; Brooks RA; Panchal R; Rhyasen GW; Danet-Desnoyers G; Mulloy JC. 2014. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood 123(24):e134-44. PubMed: 24778156 MGI: J:217446
Xie H; Xu J; Hsu JH; Nguyen M; Fujiwara Y; Peng C; Orkin SH. 2014. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 14(1):68-80. PubMed: 24239285 MGI: J:205522
Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL. 2015. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells 33(2):468-78. PubMed: 25329668 MGI: J:223580
Xie Y; Akpinarli A; Maris C; Hipkiss EL; Lane M; Kwon EK; Muranski P; Restifo NP; Antony PA. 2010. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med 207(3):651-67. PubMed: 20156973 MGI: J:158128
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF. 2016. Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma. Cancer Res 76(23):6901-6910. PubMed: 27634757 MGI: J:237854
Xu X; Weiss ID; Zhang HH; Singh SP; Wynn TA; Wilson MS; Farber JM. 2014. Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol 192(4):1778-86. PubMed: 24442439 MGI: J:209361
XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. PubMed: 19805087 MGI: J:153698
Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106(9):3227-33. PubMed: 16020505 MGI: J:123902
Yamauchi T; Takenaka K; Urata S; Shima T; Kikushige Y; Tokuyama T; Iwamoto C; Nishihara M; Iwasaki H; Miyamoto T; Honma N; Nakao M; Matozaki T; Akashi K. 2013. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood 121(8):1316-25. PubMed: 23293079 MGI: J:194763
Yang C; Loehn M; Jurczyk A; Przewozniak N; Leehy L; Herrera PL; Shultz LD; Greiner DL; Harlan DM; Bortell R. 2015. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes 8:387-98. PubMed: 26316789 MGI: J:225120
Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. PubMed: 21724588 MGI: J:175446
Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74(4):1022-31. PubMed: 24356421 MGI: J:208172
Yang Q; Li F; Harly C; Xing S; Ye L; Xia X; Wang H; Wang X; Yu S; Zhou X; Cam M; Xue HH; Bhandoola A. 2015. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16(10):1044-50. PubMed: 26280998 MGI: J:233391
Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. PubMed: 23348745 MGI: J:194482
Yu G; Xu X; Vu MD; Kilpatrick ED; Li XC. 2006. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 203(8):1851-8. PubMed: 16864660 MGI: J:124395
Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. PubMed: 20382848 MGI: J:161539
Zecher D; Li Q; Oberbarnscheidt MH; Demetris AJ; Shlomchik WD; Rothstein DM; Lakkis FG. 2010. NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells. J Immunol 184(12):6649-57. PubMed: 20483732 MGI: J:161405
Zemp FJ; McKenzie BA; Lun X; Reilly KM; McFadden G; Yong VW; Forsyth PA. 2014. Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus. Cancer Res 74(24):7260-73. PubMed: 25336188 MGI: J:218088
Zenewicz LA; Yancopoulos GD; Valenzuela DM; Murphy AJ; Stevens S; Flavell RA. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29(6):947-57. PubMed: 19100701 MGI: J:142640
Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. PubMed: 20478526 MGI: J:160523
Zhang H; Watanabe R; Berry GJ; Vaglio A; Liao YJ; Warrington KJ; Goronzy JJ; Weyand CM. 2017. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Proc Natl Acad Sci U S A 114(6):E970-E979. PubMed: 28115719 MGI: J:240876
Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. PubMed: 21368761 MGI: J:170816
Zhang Q; Hossain DM; Duttagupta P; Moreira D; Zhao X; Won H; Buettner R; Nechaev S; Majka M; Zhang B; Cai Q; Swiderski P; Kuo YH; Forman S; Marcucci G; Kortylewski M. 2016. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood 127(13):1687-700. PubMed: 26796361 MGI: J:232638
Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. PubMed: 20668064 MGI: J:164245
Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. PubMed: 20691153 MGI: J:164900
Zhou S; Mody D; DeRavin SS; Hauer J; Lu T; Ma Z; Hacein-Bey Abina S; Gray JT; Greene MR; Cavazzana-Calvo M; Malech HL; Sorrentino BP. 2010. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood 116(6):900-8. PubMed: 20457870 MGI: J:163500
van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. PubMed: 23690475 MGI: J:204834

Additional - Prkdc^scid related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models. Carcinogenesis 36(11):1440-51. PubMed: 26424750 MGI: J:226625
Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. Blood 116(12):2103-11. PubMed: 20554971 MGI: J:164507
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. PubMed: 18688847 MGI: J:142410
Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma. Br J Haematol 89(2):319-27. PubMed: 7873382 MGI: J:22989
Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340-8. PubMed: 16081804 MGI: J:107507
Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. Int Immunol 10(1):17-25. PubMed: 9488152 MGI: J:110480
Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. J Immunol 173(11):6667-75. PubMed: 15557158 MGI: J:94366
Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A 105(47):18366-71. PubMed: 19017790 MGI: J:142215
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. PubMed: 22937164 MGI: J:191672
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. PubMed: 12646649 MGI: J:125443
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo. Stem Cells 33(4):1200-12. PubMed: 25532725 MGI: J:224046
Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 66(15):7734-40. PubMed: 16885376 MGI: J:112102
Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol 188(10):4792-800. PubMed: 22516957 MGI: J:188666
Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 103(8):1201-9. PubMed: 10207172 MGI: J:108737
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer. Cancer Cell 20(6):755-67. PubMed: 22172721 MGI: J:178597
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. PubMed: 18402690 MGI: J:134670
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. PubMed: 17438029 MGI: J:122426
Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. PubMed: 20668220 MGI: J:163262
Araki R; Fujimori A; Hamatani K; Mita K; Saito T; Mori M; Fukumura R; Morimyo M; Muto M; Itoh M; Tatsumi K; Abe M. 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A 94(6):2438-43. PubMed: 9122213 MGI: J:39329
Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. PubMed: 23529621 MGI: J:199531
Arendt LM; McCready J; Keller PJ; Baker DD; Naber SP; Seewaldt V; Kuperwasser C. 2013. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res 73(19):6080-93. PubMed: 23959857 MGI: J:202607
Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. PubMed: 10899912 MGI: J:63645
Aspord C; Rome S; Thivolet C. 2004. Early events in islets and pancreatic lymph nodes in autoimmune diabetes. J Autoimmun 23(1):27-35. PubMed: 15236750 MGI: J:91668
Augstein P; Stephens LA; Allison J; Elefanty AG; Ekberg M; Kay TW; Harrison LC. 1998. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med 4(8):495-501. PubMed: 9742505 MGI: J:133840
Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. PubMed: 9686607 MGI: J:49819
Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. PubMed: 22065769 MGI: J:180174
Baker RL; Delong T; Barbour G; Bradley B; Nakayama M; Haskins K. 2013. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol 191(8):3990-4. PubMed: 24043895 MGI: J:206266
Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. PubMed: 11120869 MGI: J:66103
Balavenkatraman KK; Aceto N; Britschgi A; Mueller U; Bence KK; Neel BG; Bentires-Alj M. 2011. Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance. Mol Cancer Res 9(10):1377-84. PubMed: 21849469 MGI: J:205401
Baleriola J; Suarez T; de la Rosa EJ. 2010. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ 17(11):1697-706. PubMed: 20448641 MGI: J:186357
Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. PubMed: 23776508 MGI: J:204234
Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. PubMed: 21576342 MGI: J:173478
Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Am J Pathol 178(1):161-74. PubMed: 21224054 MGI: J:168235
Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood 115(13):2640-8. PubMed: 20124219 MGI: J:162610
Banga SS; Hall KT; Sandhu AK; Weaver DT; Athwal RS. 1994. Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8. Mutat Res 315(3):239-47. PubMed: 7526201 MGI: J:21219
Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. PubMed: 15308121 MGI: J:91764
Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest 119(5):1264-74. PubMed: 19349693 MGI: J:149592
Barber RC; Miccoli L; van Buul PP; Burr KL; van Duyn-Goedhart A; Angulo JF; Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat Res 554(1-2):287-95. PubMed: 15450426 MGI: J:93788
Bardeesy N; Kim M; Xu J; Kim RS; Shen Q; Bosenberg MW; Wong WH; Chin L. 2005. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol 25(10):4176-88. PubMed: 15870287 MGI: J:99136
Barrette B; Hebert MA; Filali M; Lafortune K; Vallieres N; Gowing G; Julien JP; Lacroix S. 2008. Requirement of myeloid cells for axon regeneration. J Neurosci 28(38):9363-76. PubMed: 18799670 MGI: J:142759
Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. PubMed: 21266536 MGI: J:172780
Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. PubMed: 16861670 MGI: J:112329
Battaglia M; Stabilini A; Draghici E; Migliavacca B; Gregori S; Bonifacio E; Roncarolo MG. 2006. Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells. Diabetes 55(6):1571-80. PubMed: 16731819 MGI: J:111884
Beamer WG; Shultz KL; Tennent BJ; Shultz LD. 1993. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res 53(16):3741-6. PubMed: 8339285 MGI: J:14443
Belkaid Y; Mendez S; Lira R; Kadambi N; Milon G; Sacks D. 2000. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol 165(2):969-77. PubMed: 10878373 MGI: J:120233
Bellani MA; Romanienko PJ; Cairatti DA; Camerini-Otero RD. 2005. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. J Cell Sci 118(Pt 15):3233-45. PubMed: 15998665 MGI: J:100203
Bello-Irizarry SN; Wang J; Johnston CJ; Gigliotti F; Wright TW. 2014. MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection. J Immunol 192(1):282-92. PubMed: 24293628 MGI: J:207087
Benavente CA; McEvoy JD; Finkelstein D; Wei L; Kang G; Wang YD; Neale G; Ragsdale S; Valentine V; Bahrami A; Temirov J; Pounds S; Zhang J; Dyer MA. 2013. Cross-species genomic and epigenomic landscape of retinoblastoma. Oncotarget 4(6):844-59. PubMed: 23765217 MGI: J:207640
Benner EJ; Banerjee R; Reynolds AD; Sherman S; Pisarev VM; Tsiperson V; Nemachek C; Ciborowski P; Przedborski S; Mosley RL; Gendelman HE. 2008. Nitrated alpha-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons. PLoS One 3(1):e1376. PubMed: 18167537 MGI: J:131300
Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa. Infect Immun 60(8):3117-21. PubMed: 1639480 MGI: J:2117
Bettini M; Castellaw AH; Lennon GP; Burton AR; Vignali DA. 2012. Prevention of autoimmune diabetes by ectopic pancreatic beta-cell expression of interleukin-35. Diabetes 61(6):1519-26. PubMed: 22427377 MGI: J:196852
Biedermann KA; Sun JR; Giaccia AJ; Tosto LM; Brown JM. 1991. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A 88(4):1394-7. PubMed: 1996340 MGI: J:89590
Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. PubMed: 23833235 MGI: J:205706
Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. PubMed: 11452126 MGI: J:125465
Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. PubMed: 15153508 MGI: J:90518
Blanc L; Ciciotte SL; Gwynn B; Hildick-Smith GJ; Pierce EL; Soltis KA; Cooney JD; Paw BH; Peters LL. 2012. Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A 109(30):12099-104. PubMed: 22773809 MGI: J:186485
Blunt T; Gell D; Fox M; Taccioli GE; Lehmann AR; Jackson SP; Jeggo PA. 1996. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A 93(19):10285-90. PubMed: 8816792 MGI: J:35393
Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. PubMed: 22890824 MGI: J:191833
Bobbala D; Kandhi R; Chen X; Mayhue M; Bouchard E; Yan J; Knecht H; Barabe F; Ramanathan S; Ilangumaran S. 2016. Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency. Leukemia 30(8):1749-52. PubMed: 26876593 MGI: J:233962
Boggiatto PM; Jie F; Ghosh M; Gibson-Corley KN; Ramer-Tait AE; Jones DE; Petersen CA. 2009. Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. Am J Pathol 174(5):1818-26. PubMed: 19349356 MGI: J:147971
Bogue MA; Zhu C; Aguilar-Cordova E; Donehower LA; Roth DB. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev 10(5):553-65. PubMed: 8598286 MGI: J:31868
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. PubMed: 20688981 MGI: J:167433
Boldizsar F; Tarjanyi O; Nemeth P; Mikecz K; Glant TT. 2009. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol 21(5):511-22. PubMed: 19254958 MGI: J:148186
Bolz DD; Sundsbak RS; Ma Y; Akira S; Kirschning CJ; Zachary JF; Weis JH; Weis JJ. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol 173(3):2003-10. PubMed: 15265935 MGI: J:92031
Bolz DD; Sundsbak RS; Ma Y; Akira S; Weis JH; Schwan TG; Weis JJ. 2006. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun 74(12):6750-60. PubMed: 17030581 MGI: J:116070
Bonifazi P; Zelante T; D'Angelo C; De Luca A; Moretti S; Bozza S; Perruccio K; Iannitti RG; Giovannini G; Volpi C; Fallarino F; Puccetti P; Romani L. 2009. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol 2(4):362-74. PubMed: 19421183 MGI: J:193381
Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301(5900):527-30. PubMed: 6823332 MGI: J:6958
Bosma GC; Oshinsky J; Kiefer K; Nakajima PB; Charan D; Congelton C; Radic M; Bosma MJ. 2006. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol 176(2):889-98. PubMed: 16393973 MGI: J:126632
Bosma M; Schuler W; Bosma G. 1988. The scid mouse mutant. Curr Top Microbiol Immunol 137:197-202. PubMed: 3416632 MGI: J:9341
Boyartchuk V; Rojas M; Yan BS; Jobe O; Hurt N; Dorfman DM; Higgins DE; Dietrich WF; Kramnik I. 2004. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J Immunol 173(8):5112-20. PubMed: 15470055 MGI: J:93705
Brackett CM; Kojouharov B; Veith J; Greene KF; Burdelya LG; Gollnick SO; Abrams SI; Gudkov AV. 2016. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Proc Natl Acad Sci U S A 113(7):E874-83. PubMed: 26831100 MGI: J:230433
Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. PubMed: 23376950 MGI: J:194546
Bregenholt S; Claesson MH. 1998. Splenic T helper cell type 1 cytokine profile and extramedullary haematopoiesis in severe combined immunodeficient (scid) mice with inflammatory bowel disease (IBD). Clin Exp Immunol 111(1):166-72. PubMed: 9472677 MGI: J:45450
Bregenholt S; Claesson MH. 1998. Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur J Immunol 28(1):379-89. PubMed: 9485217 MGI: J:45906
Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. PubMed: 22246028 MGI: J:180273
Brem-Exner BG; Sattler C; Hutchinson JA; Koehl GE; Kronenberg K; Farkas S; Inoue S; Blank C; Knechtle SJ; Schlitt HJ; Fandrich F; Geissler EK. 2008. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol 180(1):335-49. PubMed: 18097035 MGI: J:130932
Bridgett M; Cetkovic-Cvrlje M; O'Rourke R; Shi Y; Narayanswami S; Lambert J; Ramiya V; Baekkeskov S; Leiter EH. 1998. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. Diabetes 47(12):1848-56. PubMed: 9836515 MGI: J:100251
Browning JL; Allaire N; Ngam-Ek A; Notidis E; Hunt J; Perrin S; Fava RA. 2005. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity 23(5):539-50. PubMed: 16286021 MGI: J:113284
Bruedigam C; Bagger FO; Heidel FH; Paine Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee E; Riyat S; Moore AS; Lock RB; Bullinger L; Hill GR; Armstrong SA; Williams DA; Lane SW. 2014. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell 15(6):775-90. PubMed: 25479751 MGI: J:223853
Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. PubMed: 17681665 MGI: J:126691
Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. PubMed: 23223360 MGI: J:194620
Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. PubMed: 11152110 MGI: J:66571
Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. PubMed: 15688349 MGI: J:96737
Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. PubMed: 17376910 MGI: J:153321
Burke SD; Barrette VF; Carter AL; Gravel J; Adams MA; Croy BA. 2011. Cardiovascular adaptations of pregnancy in T and B cell-deficient mice. Biol Reprod 85(3):605-14. PubMed: 21613629 MGI: J:176701
Burr KL; Smith AG; Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene 24(26):4315-8. PubMed: 15806156 MGI: J:99550
Butler JM; Nolan DJ; Vertes EL; Varnum-Finney B; Kobayashi H; Hooper AT; Seandel M; Shido K; White IA; Kobayashi M; Witte L; May C; Shawber C; Kimura Y; Kitajewski J; Rosenwaks Z; Bernstein ID; Rafii S. 2010. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 6(3):251-64. PubMed: 20207228 MGI: J:158983
Calderon B; Suri A; Unanue ER. 2006. In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model. Am J Pathol 169(6):2137-47. PubMed: 17148676 MGI: J:116218
Callen E; Jankovic M; Wong N; Zha S; Chen HT; Difilippantonio S; Di Virgilio M; Heidkamp G; Alt FW; Nussenzweig A; Nussenzweig M. 2009. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34(3):285-97. PubMed: 19450527 MGI: J:150435
Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. PubMed: 16549598 MGI: J:123753
Carter CR; Whitcomb JP; Campbell JA; Mukbel RM; McDowell MA. 2009. Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice. Infect Immun 77(12):5668-75. PubMed: 19797068 MGI: J:155481
Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32(4):860-73. PubMed: 24715688 MGI: J:210438
Chang Y; Bosma GC; Bosma MJ. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity 2(6):607-16. PubMed: 7796294 MGI: J:27341
Chang Y; Bosma MJ. 1997. Effect of different Ig transgenes on B cell differentiation in scid mice. Int Immunol 9(3):373-80. PubMed: 9088976 MGI: J:125479
Chaparro RJ; Konigshofer Y; Beilhack GF; Shizuru JA; McDevitt HO; Chien YH. 2006. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc Natl Acad Sci U S A 103(33):12475-80. PubMed: 16895987 MGI: J:111775
Chen AM; Zhou Y; Swenson K; Sachs DH; Sykes M; Yang YG. 2000. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation 69(12):2484-90. PubMed: 10910267 MGI: J:93486
Chen CC; Murray PJ; Jiang TX; Plikus MV; Chang YT; Lee OK; Widelitz RB; Chuong CM. 2014. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol 134(8):2086-96. PubMed: 24618599 MGI: J:212840
Chen CH; Yeh YC; Wu GJ; Huang YH; Lai WF; Liu JY; Tzeng CR. 2010. Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction 140(1):105-12. PubMed: 20423932 MGI: J:175817
Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. PubMed: 20016601 MGI: J:155800
Chen G; Han G; Wang J; Wang R; Xu R; Shen B; Qian J; Li Y. 2009. Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta. Am J Pathol 175(3):1086-94. PubMed: 19644014 MGI: J:152908
Chen J; Chen YG; Reifsnyder PC; Schott WH; Lee CH; Osborne M; Scheuplein F; Haag F; Koch-Nolte F; Serreze DV; Leiter EH. 2006. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol 176(8):4590-9. PubMed: 16585549 MGI: J:108097
Chen J; Gusdon AM; Piganelli J; Leiter EH; Mathews CE. 2011. mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic beta-cell. Diabetes 60(1):355-9. PubMed: 20980458 MGI: J:170153
Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. PubMed: 24474774 MGI: J:206650
Chen YT; Chen FY; Vijmasi T; Stephens DN; Gallup M; McNamara NA. 2013. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One 8(10):e77286. PubMed: 24143217 MGI: J:209118
Chen Z; Zhang Y; Jia C; Wang Y; Lai P; Zhou X; Wang Y; Song Q; Lin J; Ren Z; Gao Q; Zhao Z; Zheng H; Wan Z; Gao T; Zhao A; Dai Y; Bai X. 2014. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene 33(37):4548-57. PubMed: 24096482 MGI: J:214352
Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A 113(7):E854-63. PubMed: 26831077 MGI: J:230438
Chi X; Zhi L; Gelderman MP; Vostal JG. 2012. Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. PLoS One 7(9):e44829. PubMed: 23028636 MGI: J:191794
Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. PubMed: 15383569 MGI: J:93729
Chiaraviglio L; Duong S; Brown DA; Birtles RJ; Kirby JE. 2010. An immunocompromised murine model of chronic Bartonella infection. Am J Pathol 176(6):2753-63. PubMed: 20395436 MGI: J:161161
Chirieleison SM; Feduska JM; Schugar RC; Askew Y; Deasy BM. 2012. Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice. Tissue Eng Part A 18(3-4):232-41. PubMed: 21854253 MGI: J:181239
Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. PubMed: 23965627 MGI: J:205431
Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. PubMed: 21429805 MGI: J:173961
Choi S; Chen Z; Tang LH; Fang Y; Shin SJ; Panarelli NC; Chen YT; Li Y; Jiang X; Du YC. 2016. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun 7:10384. PubMed: 26785948 MGI: J:235886
Chou FC; Shieh SJ; Sytwu HK. 2009. Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39(9):2403-11. PubMed: 19670381 MGI: J:152168
Chow LH. 1993. Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations. Lab Anim Sci 43(2):133-5. PubMed: 8391609 MGI: J:12476
Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. PubMed: 9103418 MGI: J:102141
Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. PubMed: 8806787 MGI: J:34814
Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res 76(23):6964-6974. PubMed: 27671674 MGI: J:237848
Clemente-Casares X; Blanco J; Ambalavanan P; Yamanouchi J; Singha S; Fandos C; Tsai S; Wang J; Garabatos N; Izquierdo C; Agrawal S; Keough MB; Yong VW; James E; Moore A; Yang Y; Stratmann T; Serra P; Santamaria P. 2016. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 530(7591):434-40. PubMed: 26886799 MGI: J:229667
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. PubMed: 23378057 MGI: J:196312
Cook AJ; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ. 2003. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J Immunol 171(12):6556-64. PubMed: 14662857 MGI: J:117994
Coombes JL; Siddiqui KR; Arancibia-Carcamo CV; Hall J; Sun CM; Belkaid Y; Powrie F. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757-64. PubMed: 17620361 MGI: J:203901
Coppola V; Barrick CA; Southon EA; Celeste A; Wang K; Chen B; Haddad el-B; Yin J; Nussenzweig A; Subramaniam A; Tessarollo L. 2004. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131(20):5185-95. PubMed: 15459109 MGI: J:93578
Cosgun KN; Rahmig S; Mende N; Reinke S; Hauber I; Schafer C; Petzold A; Weisbach H; Heidkamp G; Purbojo A; Cesnjevar R; Platz A; Bornhauser M; Schmitz M; Dudziak D; Hauber J; Kirberg J; Waskow C. 2014. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 15(2):227-38. PubMed: 25017720 MGI: J:232320
Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. PubMed: 23869841 MGI: J:200896
Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. PubMed: 21985373 MGI: J:177904
Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice. J Endocrinol 191(2):415-25. PubMed: 17088411 MGI: J:114701
Crowe MJ; Doetschman T; Greenhalgh DG. 2000. Delayed wound healing in immunodeficient TGF-beta1 knockout mice J Invest Dermatol 115(1):3-11. PubMed: 10886500 MGI: J:63260
Crowley SD; Song YS; Lin EE; Griffiths R; Kim HS; Ruiz P. 2010. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 298(4):R1089-97. PubMed: 20147609 MGI: J:158609
Culmsee C; Bondada S; Mattson MP. 2001. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res 87(2):257-62. PubMed: 11245929 MGI: J:109293
Cupedo T; Lund FE; Ngo VN; Randall TD; Jansen W; Greuter MJ; de Waal-Malefyt R; Kraal G; Cyster JG; Mebius RE. 2004. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol 173(8):4889-96. PubMed: 15470030 MGI: J:93711
Custer RP; Bosma GC; Bosma MJ. 1985. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 120(3):464-77. PubMed: 2412448 MGI: J:30980
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease. Sci Transl Med 7(281):281ra42. PubMed: 25834108 MGI: J:234081
Dann SM; Spehlmann ME; Hammond DC; Iimura M; Hase K; Choi LJ; Hanson E; Eckmann L. 2008. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 180(10):6816-26. PubMed: 18453602 MGI: J:134871
Danska JS; Holland DP; Mariathasan S; Williams KM; Guidos CJ. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol 16(10):5507-17. PubMed: 8816463 MGI: J:35350
Darwiche R; Chong MM; Santamaria P; Thomas HE; Kay TW. 2003. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 170(12):6292-7. PubMed: 12794162 MGI: J:108698
Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. PubMed: 23430111 MGI: J:196692
De Luca A; Carvalho A; Cunha C; Iannitti RG; Pitzurra L; Giovannini G; Mencacci A; Bartolommei L; Moretti S; Massi-Benedetti C; Fuchs D; De Bernardis F; Puccetti P; Romani L. 2013. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog 9(7):e1003486. PubMed: 23853597 MGI: J:213365
De Palma M; Venneri MA; Galli R; Sergi LS; Politi LS; Sampaolesi M; Naldini L. 2005. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211-26. PubMed: 16169466 MGI: J:102241
Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067-80. PubMed: 20439540 MGI: J:160932
DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol 105(3):332-41. PubMed: 12498815 MGI: J:94192
Diamond RA; Ward SB; Owada-Makabe K; Wang H; Rothenberg EV. 1997. Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J Immunol 158(9):4052-64. PubMed: 9126963 MGI: J:39793
Diaz-Manera J; Touvier T; Dellavalle A; Tonlorenzi R; Tedesco FS; Messina G; Meregalli M; Navarro C; Perani L; Bonfanti C; Illa I; Torrente Y; Cossu G. 2010. Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy. Cell Death Dis 1:e61. PubMed: 21364666 MGI: J:186461
Dibra D; Cutrera JJ; Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol 188(8):3709-15. PubMed: 22407920 MGI: J:184078
Dodig TD; Mack KT; Cassarino DF; Clark SH. 2001. Development of the tight-skin phenotype in immune-deficient mice. Arthritis Rheum 44(3):723-7. PubMed: 11263788 MGI: J:112962
Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. PubMed: 9144497 MGI: J:40202
Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. PubMed: 15466391 MGI: J:93676
Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. PubMed: 12612906 MGI: J:82106
Dominique V; Francis L. 1995. Interactions of the scid or beige mutations with the viable motheaten mutation. Autoimmunity 22(4):199-207. PubMed: 8781712 MGI: J:33985
Dorshkind K; Keller GM; Phillips RA; Miller RG; Bosma GC; O'Toole M; Bosma MJ. 1984. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol 132(4):1804-8. PubMed: 6607948 MGI: J:7343
Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. PubMed: 23896410 MGI: J:202360
Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. PubMed: 22593616 MGI: J:188965
Dudek NL; Thomas HE; Mariana L; Sutherland RM; Allison J; Estella E; Angstetra E; Trapani JA; Santamaria P; Lew AM; Kay TW. 2006. Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 55(9):2412-8. PubMed: 16936188 MGI: J:116592
Dudley ME; Sundberg JP; Roopenian DC. 1996. Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. Int J Cancer 65(2):249-53. PubMed: 8567125 MGI: J:31690
Dullin C; Missbach-Guentner J; Vogel WF; Grabbe E; Alves F. 2007. Semi-Automatic Classification of Skeletal Morphology in Genetically Altered Mice Using Flat-Panel Volume Computed Tomography. PLoS Genet 3(7):e118. PubMed: 17658952 MGI: J:123719
Dumont N; Boyer L; Emond H; Celebi-Saltik B; Pasha R; Bazin R; Mantovani D; Roy DC; Pineault N. 2014. Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors. Exp Hematol 42(9):741-752.e1. PubMed: 24793546 MGI: J:214003
Eaton KA; Benson LH; Haeger J; Gray BM. 2006. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice. Infect Immun 74(8):4673-84. PubMed: 16861655 MGI: J:112403
Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. PubMed: 11390498 MGI: J:124425
Ebrahem Q; Chaurasia SS; Vasanji A; Qi JH; Klenotic PA; Cutler A; Asosingh K; Erzurum S; Anand-Apte B. 2010. Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. Am J Pathol 176(1):496-503. PubMed: 19948826 MGI: J:156380
Economopoulos V; Noad JC; Krishnamoorthy S; Rutt BK; Foster PJ. 2011. Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. PLoS One 6(11):e27508. PubMed: 22096586 MGI: J:180968
Elsegeiny W; Eddens T; Chen K; Kolls JK. 2015. Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia. Infect Immun 83(5):2043-52. PubMed: 25733518 MGI: J:229720
Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 162(9):5094-8. PubMed: 10227978 MGI: J:111009
Engle SJ; Ormsby I; Pawlowski S; Boivin GP; Croft J; Balish E; Doetschman T. 2002. Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice. Cancer Res 62(22):6362-6. PubMed: 12438215 MGI: J:80209
Ernst PB; Erickson LD; Loo WM; Scott KG; Wiznerowicz EB; Brown CC; Torres-Velez FJ; Alam MS; Black SG; McDuffie M; Feldman SH; Wallace JL; McKnight GW; Padol IT; Hunt RH; Tung KS. 2012. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. Am J Physiol Gastrointest Liver Physiol 302(1):G105-15. PubMed: 21921286 MGI: J:183342
Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751-60. PubMed: 23612011 MGI: J:203569
Fahlen L; Read S; Gorelik L; Hurst SD; Coffman RL; Flavell RA; Powrie F. 2005. T cells that cannot respond to TGF-{beta} escape control by CD4+CD25+ regulatory T cells. J Exp Med 201(5):737-46. PubMed: 15753207 MGI: J:96624
Faleo G; Fotino C; Bocca N; Molano RD; Zahr-Akrawi E; Molina J; Villate S; Umland O; Skyler JS; Bayer AL; Ricordi C; Pileggi A. 2012. Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes 61(7):1769-78. PubMed: 22566533 MGI: J:203601
Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. PubMed: 22617213 MGI: J:185539
Farini A; Meregalli M; Belicchi M; Battistelli M; Parolini D; D'Antona G; Gavina M; Ottoboni L; Constantin G; Bottinelli R; Torrente Y. 2007. T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse. J Pathol 213(2):229-38. PubMed: 17668421 MGI: J:125527
Farini A; Sitzia C; Navarro C; D'Antona G; Belicchi M; Parolini D; Del Fraro G; Razini P; Bottinelli R; Meregalli M; Torrente Y. 2012. Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model. Exp Cell Res 318(10):1160-74. PubMed: 22465227 MGI: J:186460
Fattahi F; Steinbeck JA; Kriks S; Tchieu J; Zimmer B; Kishinevsky S; Zeltner N; Mica Y; El-Nachef W; Zhao H; de Stanchina E; Gershon MD; Grikscheit TC; Chen S; Studer L. 2016. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature 531(7592):105-9. PubMed: 26863197 MGI: J:229669
Feng M; Chen JY; Weissman-Tsukamoto R; Volkmer JP; Ho PY; McKenna KM; Cheshier S; Zhang M; Guo N; Gip P; Mitra SS; Weissman IL. 2015. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A 112(7):2145-50. PubMed: 25646432 MGI: J:220007
Fernandez NC; Lozier A; Flament C; Ricciardi-Castagnoli P; Bellet D; Suter M; Perricaudet M; Tursz T; Maraskovsky E; Zitvogel L. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5(4):405-11. PubMed: 10202929 MGI: J:54135
Fiorucci S; Mencarelli A; Palazzetti B; Sprague AG; Distrutti E; Morelli A; Novobrantseva TI; Cirino G; Koteliansky VE; de Fougerolles AR. 2002. Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity 17(6):769-80. PubMed: 12479823 MGI: J:113581
Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion. J Immunol 180(6):3874-81. PubMed: 18322195 MGI: J:133031
Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. PubMed: 23467088 MGI: J:194916
Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. PubMed: 9834083 MGI: J:115033
Foquet L; Hermsen CC; van Gemert GJ; Van Braeckel E; Weening KE; Sauerwein R; Meuleman P; Leroux-Roels G. 2014. Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest 124(1):140-4. PubMed: 24292709 MGI: J:207925
Forbes JM; Soderlund J; Yap FY; Knip M; Andrikopoulos S; Ilonen J; Simell O; Veijola R; Sourris KC; Coughlan MT; Forsblom C; Slattery R; Grey ST; Wessman M; Yamamoto H; Bierhaus A; Cooper ME; Groop PH. 2011. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia :. PubMed: 21298413 MGI: J:169600
Ford ML; Evavold BD. 2006. Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. Cell Immunol 240(1):53-61. PubMed: 16890924 MGI: J:112761
Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. PubMed: 21266499 MGI: J:168554
Fournier B; Murray B; Gutzwiller S; Marcaletti S; Marcellin D; Bergling S; Brachat S; Persohn E; Pierrel E; Bombard F; Hatakeyama S; Trendelenburg AU; Morvan F; Richardson B; Glass DJ; Lach-Trifilieff E; Feige JN. 2012. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol 32(14):2871-9. PubMed: 22586266 MGI: J:186659
Franco S; Murphy MM; Li G; Borjeson T; Boboila C; Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205(3):557-64. PubMed: 18316419 MGI: J:133132
Frese M; Lee E; Larena M; Lim PS; Rao S; Matthaei KI; Khromykh A; Ramshaw I; Lobigs M. 2014. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol 88(4):2056-70. PubMed: 24307589 MGI: J:205265
Friedline RH; Ko HJ; Jung DY; Lee Y; Bortell R; Dagdeviren S; Patel PR; Hu X; Inashima K; Kearns C; Tsitsilianos N; Shafiq U; Shultz LD; Lee KW; Greiner DL; Kim JK. 2016. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J 30(3):1328-38. PubMed: 26644351 MGI: J:230896
Friswell MK; Gika H; Stratford IJ; Theodoridis G; Telfer B; Wilson ID; McBain AJ. 2010. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS One 5(1):e8584. PubMed: 20052418 MGI: J:157249
Fuentes RE; Zaitsev S; Ahn HS; Hayes V; Kowalska MA; Lambert MP; Wang Y; Siegel DL; Bougie DW; Aster RH; Myers DD; Stepanova V; Cines DB; Muzykantov VR; Poncz M. 2015. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. J Clin Invest :. PubMed: 26690701 MGI: J:231183
Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. PubMed: 20729912 MGI: J:166563
Fulop GM; Phillips RA. 1986. Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients. J Immunol 136(12):4438-43. PubMed: 3519770 MGI: J:8299
Fyfe AI; Qiao JH; Lusis AJ. 1994. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 94(6):2516-20. PubMed: 7989611 MGI: J:22138
Gallo-Hendrikx E; Percy D; Copps J; McKeown B; Quinton M; McMillan I; Croy BA; Wildeman AG. 1999. Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors. APMIS 107(2):245-56. PubMed: 10225324 MGI: J:54114
Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. PubMed: 11426950 MGI: J:102684
Garcia-Barros M; Thin TH; Maj J; Cordon-Cardo C; Haimovitz-Friedman A; Fuks Z; Kolesnick R. 2010. Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res 70(20):8179-86. PubMed: 20924105 MGI: J:165564
Garcia-Rivera MF; Colvin-Wanshura LE; Nelson MS; Nan Z; Khan SA; Rogers TB; Maitra I; Low WC; Gupta P. 2007. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Brain Res Bull 74(6):429-38. PubMed: 17920451 MGI: J:139626
Gawronska-Kozak B; Bogacki M; Rim JS; Monroe WT; Manuel JA. 2006. Scarless skin repair in immunodeficient mice. Wound Repair Regen 14(3):265-76. PubMed: 16808805 MGI: J:135709
Gelman AE; LaRosa DF; Zhang J; Walsh PT; Choi Y; Sunyer JO; Turka LA. 2006. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 25(5):783-93. PubMed: 17055754 MGI: J:116106
Gerling IC; Friedman H; Greiner DL; Shultz LD; Leiter EH. 1994. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes 43(3):433-40. PubMed: 8314017 MGI: J:16998
Gesina E; Blondeau B; Milet A; Le Nin I; Duchene B; Czernichow P; Scharfmann R; Tronche F; Breant B. 2006. Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Diabetologia 49(12):2939-47. PubMed: 17001468 MGI: J:147261
Gittens JE; Barr KJ; Vanderhyden BC; Kidder GM. 2005. Interplay between paracrine signaling and gap junctional communication in ovarian follicles. J Cell Sci 118(Pt 1):113-22. PubMed: 15585573 MGI: J:94692
Gladdy RA; Nutter LM; Kunath T; Danska JS; Guidos CJ. 2006. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 4(5):311-8. PubMed: 16687486 MGI: J:108789
Gladdy RA; Taylor MD; Williams CJ; Grandal I; Karaskova J; Squire JA; Rutka JT; Guidos CJ; Danska JS. 2003. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 3(1):37-50. PubMed: 12559174 MGI: J:81538
Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107(2):199-206. PubMed: 11160136 MGI: J:66974
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. PubMed: 20671189 MGI: J:162606
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. PubMed: 20495069 MGI: J:161304
Graff RJ. 1970. Polymorphism of histocompatibility genes in the mouse. Transplant Proc 2(1):15-23. PubMed: 4107291 MGI: J:5237
Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. PubMed: 10725754 MGI: J:93553
Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. PubMed: 11920579 MGI: J:115364
Green-Mitchell SM; Tersey SA; Cole BK; Ma K; Kuhn NS; Cunningham TD; Maybee NA; Chakrabarti SK; McDuffie M; Taylor-Fishwick DA; Mirmira RG; Nadler JL; Morris MA. 2013. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One 8(2):e56763. PubMed: 23437231 MGI: J:197192
Grenningloh R; Kang BY; Ho IC. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med 201(4):615-26. PubMed: 15728239 MGI: J:96627
Griffin RL; Kupper TS; Divito SJ. 2015. Humanized Mice in Dermatology Research. J Invest Dermatol 135(12):e39. PubMed: 26569593 MGI: J:228055
Guay HM; Andreyeva TA; Garcea RL; Welsh RM; Szomolanyi-Tsuda E. 2007. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol 178(8):5124-31. PubMed: 17404295 MGI: J:145278
Guay HM; Panarey L; Reed AJ; Caton AJ. 2004. Specificity-based negative selection of autoreactive B cells during memory formation. J Immunol 173(9):5485-94. PubMed: 15494496 MGI: J:93744
Guidos CJ; Williams CJ; Grandal I; Knowles G; Huang MT; Danska JS. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 10(16):2038-54. PubMed: 8769647 MGI: J:102044
Gundry MC; Brunetti L; Lin A; Mayle AE; Kitano A; Wagner D; Hsu JI; Hoegenauer KA; Rooney CM; Goodell MA; Nakada D. 2016. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep 17(5):1453-1461. PubMed: 27783956 MGI: J:240901
Gurley KE; Kemp CJ. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol 11(3):191-4. PubMed: 11231155 MGI: J:67533
Gurley KE; Vo K; Kemp CJ. 1998. DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice. Cancer Res 58(14):3111-5. PubMed: 9679979 MGI: J:49372
Haetscher N; Feuermann Y; Wingert S; Rehage M; Thalheimer FB; Weiser C; Bohnenberger H; Jung K; Schroeder T; Serve H; Oellerich T; Hennighausen L; Rieger MA. 2015. STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nat Commun 6:8928. PubMed: 26603207 MGI: J:228007
Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. PubMed: 12626535 MGI: J:126301
Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101. PubMed: 10435582 MGI: J:110456
Halim TY; Maclaren A; Romanish MT; Gold MJ; McNagny KM; Takei F. 2012. Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37(3):463-74. PubMed: 22981535 MGI: J:187662
Halin C; Tobler NE; Vigl B; Brown LF; Detmar M. 2007. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 110(9):3158-67. PubMed: 17625067 MGI: J:148904
Haller BL; Barkon ML; Vogler GP; Virgin HW 4th. 1995. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes. J Virol 69(1):357-64. PubMed: 7983730 MGI: J:21933
Han D; Walsh MC; Cejas PJ; Dang NN; Kim YF; Kim J; Charrier-Hisamuddin L; Chau L; Zhang Q; Bittinger K; Bushman FD; Turka LA; Shen H; Reizis B; Defranco AL; Wu GD; Choi Y. 2013. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity 38(6):1211-22. PubMed: 23791643 MGI: J:207581
Han SJ; Jung SY; Wu SP; Hawkins SM; Park MJ; Kyo S; Qin J; Lydon JP; Tsai SY; Tsai MJ; DeMayo FJ; O'Malley BW. 2015. Estrogen Receptor beta Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell 163(4):960-74. PubMed: 26544941 MGI: J:228035
Hande P; Slijepcevic P; Silver A; Bouffler S; van Buul P; Bryant P ; Lansdorp P. 1999. Elongated telomeres in scid mice. Genomics 56(2):221-3. PubMed: 10051409 MGI: J:53579
Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. PubMed: 23925295 MGI: J:201617
Harkness RE; Guimond MJ; McBey BA; Klein MH; Percy DH; Croy BA. 1993. Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report. APMIS 101(10):805-10. PubMed: 8267959 MGI: J:16050
Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. PubMed: 22464800 MGI: J:189339
Hasegawa M; Kawai K; Mitsui T; Taniguchi K; Monnai M; Wakui M; Ito M; Suematsu M; Peltz G; Nakamura M; Suemizu H. 2011. The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem Biophys Res Commun 405(3):405-10. PubMed: 21238430 MGI: J:170638
Hastey CJ; Elsner RA; Barthold SW; Baumgarth N. 2012. Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. J Immunol 188(11):5612-22. PubMed: 22547698 MGI: J:188726
Hayakawa Y; Sakitani K; Konishi M; Asfaha S; Niikura R; Tomita H; Renz BW; Tailor Y; Macchini M; Middelhoff M; Jiang Z; Tanaka T; Dubeykovskaya ZA; Kim W; Chen X; Urbanska AM; Nagar K; Westphalen CB; Quante M; Lin CS; Gershon MD; Hara A; Zhao CM; Chen D; Worthley DL; Koike K; Wang TC. 2017. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell 31(1):21-34. PubMed: 27989802 MGI: J:238420
Hayashi Y; Haneji N; Hamano H; Yanagi K. 1994. Transfer of Sjogren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 24(11):2826-31. PubMed: 7957574 MGI: J:21965
Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. PubMed: 10950807 MGI: J:125986
He J; Haskins K. 2008. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology 123(1):108-17. PubMed: 17983440 MGI: J:134900
He Q; Morillon YM 2nd; Spidale NA; Kroger CJ; Liu B; Sartor RB; Wang B; Tisch R. 2013. Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol 191(12):5858-66. PubMed: 24198282 MGI: J:207147
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. PubMed: 20068223 MGI: J:162612
Heine D; Passmore HC; Patel V; Shultz LD; Ward-Bailey P; Cook SA; Davisson MT. 1996. Effect of the mouse scid mutation on meiotic recombination. Mamm Genome 7(7):497-500. PubMed: 8672126 MGI: J:34473
Hernandez-Novoa B; Bishop L; Logun C; Munson PJ; Elnekave E; Rangel ZG; Barb J; Danner RL; Kovacs JA. 2008. Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol 84(2):420-30. PubMed: 18467653 MGI: J:138448
Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. PubMed: 9862708 MGI: J:115095
Hesselton RM; Greiner DL; Mordes JP; Rajan TV; Sullivan JL; Shultz LD. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis 172(4):974-82. PubMed: 7561218 MGI: J:109911
Hettmer S; Liu J; Miller CM; Lindsay MC; Sparks CA; Guertin DA; Bronson RT; Langenau DM; Wagers AJ. 2011. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A 108(50):20002-7. PubMed: 22135462 MGI: J:180528
Hilbert DM; Anderson AO; Holmes KL; Rudikoff S. 1994. Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues. Transplantation 58(4):466-75. PubMed: 8073516 MGI: J:19983
Hioki K; Kuramochi T; Endoh S; Terada E; Ueyama Y; Ito M. 2001. Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice. Exp Anim 50(1):67-72. PubMed: 11326425 MGI: J:68089
Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol 191(2):347-65. PubMed: 20956382 MGI: J:165481
Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80. PubMed: 12689924 MGI: J:163372
Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. PubMed: 12406886 MGI: J:109848
Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. PubMed: 19324903 MGI: J:148898
Holland JD; Gyorffy B; Vogel R; Eckert K; Valenti G; Fang L; Lohneis P; Elezkurtaj S; Ziebold U; Birchmeier W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep 5(5):1214-27. PubMed: 24290754 MGI: J:206839
Holm TM; Jackson-Grusby L; Brambrink T; Yamada Y; Rideout WM 3rd; Jaenisch R. 2005. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8(4):275-85. PubMed: 16226703 MGI: J:104860
Holodick NE; Vizconde T; Rothstein TL. 2014. B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location. J Immunol 192(5):2432-41. PubMed: 24477911 MGI: J:209818
Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. PubMed: 22343031 MGI: J:184937
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. PubMed: 20601939 MGI: J:162607
Hontecillas R; Bassaganya-Riera J. 2007. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol 178(5):2940-9. PubMed: 17312139 MGI: J:144105
Horai R; Nakajima A; Habiro K; Kotani M; Nakae S; Matsuki T; Nambu A; Saijo S; Kotaki H; Sudo K; Okahara A; Tanioka H; Ikuse T; Ishii N; Schwartzberg PL; Abe R; Iwakura Y. 2004. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11):1603-11. PubMed: 15578092 MGI: J:94429
Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. PubMed: 9886369 MGI: J:112424
Houghtaling S; Newell A; Akkari Y; Taniguchi T; Olson S; Grompe M. 2005. Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 14(20):3027-33. PubMed: 16135554 MGI: J:102754
Hsu DM; Agarwal S; Benham A; Coarfa C; Trahan DN; Chen Z; Stowers PN; Courtney AN; Lakoma A; Barbieri E; Metelitsa LS; Gunaratne P; Kim ES; Shohet JM. 2013. G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic. Cancer Res 73(13):4134-46. PubMed: 23687340 MGI: J:199119
Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. PubMed: 21926352 MGI: J:178783
Hua C; Chang B; Ma B-L; Li Y; Wang G. 1992. Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice ILAR News 34(1-2):S15-S16. MGI: J:2627
Huang P; Huo Y; Lou LX; Li H; Barnstable CJ; Zhang C; Zhang SS. 2013. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res 115:131-9. PubMed: 23792169 MGI: J:210412
Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. PubMed: 22753496 MGI: J:186492
Hubner MP; Shi Y; Torrero MN; Mueller E; Larson D; Soloviova K; Gondorf F; Hoerauf A; Killoran KE; Stocker JT; Davies SJ; Tarbell KV; Mitre E. 2012. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta. J Immunol 188(2):559-68. PubMed: 22174447 MGI: J:180789
Hugues S; Mougneau E; Ferlin W; Jeske D; Hofman P; Homann D; Beaudoin L; Schrike C; Von Herrath M; Lehuen A; Glaichenhaus N. 2002. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity 16(2):169-81. PubMed: 11869679 MGI: J:132052
Hull ML; Johan MZ; Hodge WL; Robertson SA; Ingman WV. 2012. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis. Am J Pathol 180(3):880-7. PubMed: 22210480 MGI: J:181959
Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7):3311-6. PubMed: 9120288 MGI: J:110835
Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M. 2013. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51(5):618-31. PubMed: 24011591 MGI: J:203811
Ingman WV; Robertson SA. 2008. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79(4):711-7. PubMed: 18614704 MGI: J:140882
Ingman WV; Robertson SA. 2007. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 148(8):4032-43. PubMed: 17478551 MGI: J:129629
Ingman WV; Robker RL; Woittiez K; Robertson SA. 2006. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology 147(2):835-45. PubMed: 16269452 MGI: J:129446
Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. PubMed: 22558161 MGI: J:187283
Ishii T; Zhao Y; Sozer S; Shi J; Zhang W; Hoffman R; Xu M. 2007. Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice. Exp Hematol 35(11):1633-40. PubMed: 17764815 MGI: J:132540
Ishii-Ohba H; Kobayashi S; Nishimura M; Shimada Y; Tsuji H; Sado T; Ogiu T. 2007. Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice. Mutat Res 619(1-2):124-33. PubMed: 17397880 MGI: J:120953
Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. PubMed: 15920010 MGI: J:142411
Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82. PubMed: 12384415 MGI: J:163373
Ito R; Katano I; Ida-Tanaka M; Kamisako T; Kawai K; Suemizu H; Aiso S; Ito M. 2012. Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rgammanull mice is attributed to a lack of CD11c+B220+CD122+ cells. J Immunol 189(9):4313-20. PubMed: 23018460 MGI: J:190612
Ito R; Negishi N; Irie N; Matsuo K; Suzuki D; Katano I; Hayakawa E; Kawai K; Kamisako T; Eto T; Ogura T; Hozumi K; Ando K; Aiso S; Tamaoki N; Habu S; Ito M. 2012. Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. Exp Hematol 40(11):953-963.e3. PubMed: 22771497 MGI: J:203591
Ito R; Takahashi T; Katano I; Kawai K; Kamisako T; Ogura T; Ida-Tanaka M; Suemizu H; Nunomura S; Ra C; Mori A; Aiso S; Ito M. 2013. Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice. J Immunol 191(6):2890-9. PubMed: 23956433 MGI: J:205873
Ito T; Seyama T; Kyoizumi S; Teraoka S; Iwamoto KS; Mizuno T; Tsuyama N; Asahara T; Dohi K; Akiyama M. 1995. The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis. Cancer Lett 88(1):113-7. PubMed: 7850767 MGI: J:23712
Iwai H; Abe M; Hirose S; Tsushima F; Tezuka K; Akiba H; Yagita H; Okumura K; Kohsaka H; Miyasaka N; Azuma M. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171(6):2848-54. PubMed: 12960306 MGI: J:120381
Jaakkola I; Jalkanen S; Hanninen A. 2003. Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice. Eur J Immunol 33(12):3255-64. PubMed: 14635033 MGI: J:87142
Jaeschke A; Rincon M; Doran B; Reilly J; Neuberg D; Greiner DL; Shultz LD; Rossini AA; Flavell RA; Davis RJ. 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 102(19):6931-5. PubMed: 15867147 MGI: J:99056
Jahchan NS; Lim JS; Bola B; Morris K; Seitz G; Tran KQ; Xu L; Trapani F; Morrow CJ; Cristea S; Coles GL; Yang D; Vaka D; Kareta MS; George J; Mazur PK; Nguyen T; Anderson WC; Dylla SJ; Blackhall F; Peifer M; Dive C; Sage J. 2016. Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer. Cell Rep 16(3):644-56. PubMed: 27373157 MGI: J:238584
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. PubMed: 19802382 MGI: J:154110
Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. PubMed: 20072130 MGI: J:162611
Jimenez de Bagues MP; de Martino A; Quintana JF; Alcaraz A; Pardo J. 2011. Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice. Infect Immun 79(10):3934-9. PubMed: 21825066 MGI: J:175995
Johnson RM; Papp E; Grandal I; Kowalski PE; Nutter L; Wong RC; Joseph-George AM; Danska JS; Guidos CJ. 2014. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis. Genes Dev 28(11):1179-90. PubMed: 24888589 MGI: J:211638
Jones-Carson J; Vazquez-Torres A; Balish E. 1995. Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis 171(6):1664-7. PubMed: 7769315 MGI: J:25930
Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. PubMed: 20505160 MGI: J:163485
Jun HS; Santamaria P; Lim HW; Zhang ML; Yoon JW. 1999. Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. Diabetes 48(1):34-42. PubMed: 9892220 MGI: J:108751
Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. PubMed: 12133972 MGI: J:120707
Kahiri CN; Khalil MW; Tekpetey F; Kidder GM. 2006. Leydig cell function in mice lacking connexin43. Reproduction 132(4):607-616. PubMed: 17008472 MGI: J:112888
Kalaany NY; Sabatini DM. 2009. Tumours with PI3K activation are resistant to dietary restriction. Nature 458(7239):725-31. PubMed: 19279572 MGI: J:147281
Kalscheuer H; Onoe T; Dahmani A; Li HW; Holzl M; Yamada K; Sykes M. 2014. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts. J Immunol 192(7):3442-50. PubMed: 24591363 MGI: J:209878
Kariya R; Taura M; Suzu S; Kai H; Katano H; Okada S. 2014. HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-kappaB pathway. Cancer Lett 342(1):52-9. PubMed: 24012878 MGI: J:204517
Katakura K; Lee J; Rachmilewitz D; Li G; Eckmann L; Raz E. 2005. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115(3):695-702. PubMed: 15765149 MGI: J:110027
Katakura T; Yoshida T; Kobayashi M; Herndon DN; Suzuki F. 2005. Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries. Clin Exp Immunol 142(3):419-25. PubMed: 16297152 MGI: J:107603
Kawaguchi-Miyashita M; Shimada S; Kurosu H; Kato-Nagaoka N; Matsuoka Y; Ohwaki M; Ishikawa H; Nanno M. 2001. An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice. Eur J Immunol 31(4):980-8. PubMed: 11298322 MGI: J:68810
Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. PubMed: 22897850 MGI: J:191823
Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13):5010-5. PubMed: 22403066 MGI: J:182225
Kazerounian S; Gerald D; Huang M; Chin YR; Udayakumar D; Zheng N; O'Donnell RK; Perruzzi C; Mangiante L; Pourat J; Phung TL; Bravo-Nuevo A; Shechter S; McNamara S; Duhadaway JB; Kocher ON; Brown LF; Toker A; Prendergast GC; Benjamin LE. 2013. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1):50-61. PubMed: 23135917 MGI: J:194113
Kelly MN; Zheng M; Ruan S; Kolls J; D'Souza A; Shellito JE. 2013. Memory CD4+ T Cells Are Required for Optimal NK Cell Effector Functions against the Opportunistic Fungal Pathogen Pneumocystis murina. J Immunol 190(1):285-95. PubMed: 23203926 MGI: J:190830
Kemp CJ; Vo K; Gurley KE. 1999. Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis. Carcinogenesis 20(11):2051-6. PubMed: 10545405 MGI: J:58425
Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. PubMed: 12433363 MGI: J:93139
Kharbanda S; Pandey P; Jin S; Inoue S; Bharti A; Yuan ZM; Weichselbaum R; Weaver D; Kufe D. 1997. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386(6626):732-5. PubMed: 9109492 MGI: J:116399
Kiaris H; Chatzistamou I; Trimis G; Frangou-Plemmenou M; Pafiti-Kondi A; Kalofoutis A. 2005. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65(5):1627-30. PubMed: 15753354 MGI: J:97031
Kiefer K; Nakajima PB; Oshinsky J; Seeholzer SH; Radic M; Bosma GC; Bosma MJ. 2008. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol 180(9):6094-106. PubMed: 18424731 MGI: J:160356
Kiefer K; Oshinsky J; Kim J; Nakajima PB; Bosma GC; Bosma MJ. 2007. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A 104(8):2843-8. PubMed: 17296939 MGI: J:125895
Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. PubMed: 21873530 MGI: J:179333
Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. PubMed: 23300950 MGI: J:195822
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. PubMed: 19659776 MGI: J:151390
Kinkel SA; Galeev R; Flensburg C; Keniry A; Breslin K; Gilan O; Lee S; Liu J; Chen K; Gearing LJ; Moore DL; Alexander WS; Dawson M; Majewski IJ; Oshlack A; Larsson J; Blewitt ME. 2015. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood 125(12):1890-900. PubMed: 25645357 MGI: J:222052
Kitamura K; Nakamoto Y; Kaneko S; Mukaida N. 2004. Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 76(6):1111-7. PubMed: 15339938 MGI: J:94173
Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. PubMed: 16294221 MGI: J:104533
Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. PubMed: 9414161 MGI: J:44933
Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. PubMed: 24209604 MGI: J:206743
Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. PubMed: 22664870 MGI: J:188934
Kodama T; Hikita H; Kawaguchi T; Saito Y; Tanaka S; Shigekawa M; Shimizu S; Li W; Miyagi T; Kanto T; Hiramatsu N; Tatsumi T; Takehara T. 2013. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. J Biol Chem 288(42):30009-18. PubMed: 23986435 MGI: J:203931
Kometani K; Aoki M; Kawamata S; Shinozuka Y; Era T; Taniwaki M; Hattori M; Minato N. 2006. Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model. Cancer Res 66(20):9967-76. PubMed: 17047059 MGI: J:114993
Kong L; Robinson CP; Peck AB; Vela-Roch N; Sakata KM; Dang H; Talal N; Humphreys-Beher MG. 1998. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clin Exp Rheumatol 16(6):675-81. PubMed: 9844759 MGI: J:53650
Kota DJ; Wiggins LL; Yoon N; Lee RH. 2013. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes 62(6):2048-58. PubMed: 23349496 MGI: J:208563
Krishnamurthy S; Warner KA; Dong Z; Imai A; Nor C; Ward BB; Helman JI; Taichman RS; Bellile EL; McCauley LK; Polverini PJ; Prince ME; Wicha MS; Nor JE. 2014. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells 32(11):2845-57. PubMed: 25078284 MGI: J:218558
Ksander BR; Kolovou PE; Wilson BJ; Saab KR; Guo Q; Ma J; McGuire SP; Gregory MS; Vincent WJ; Perez VL; Cruz-Guilloty F; Kao WW; Call MK; Tucker BA; Zhan Q; Murphy GF; Lathrop KL; Alt C; Mortensen LJ; Lin CP; Zieske JD; Frank MH; Frank NY. 2014. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature 511(7509):353-7. PubMed: 25030174 MGI: J:213708
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. PubMed: 18691745 MGI: J:142409
Kunisawa J; Gohda M; Kurashima Y; Ishikawa I; Higuchi M; Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells. Blood 111(9):4646-52. PubMed: 18292290 MGI: J:134340
Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. PubMed: 16081800 MGI: J:107508
Kurkjian C; Hollifield M; Lines JL; Rogosky A; Empey KM; Qureshi M; Brown SA; Garvy BA. 2012. Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection. Infect Immun 80(8):2835-46. PubMed: 22665378 MGI: J:186637
Kwun J; Hu H; Schadde E; Roenneburg D; Sullivan KA; DeMartino J; Burlingham WJ; Knechtle SJ. 2007. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. J Immunol 179(12):8016-25. PubMed: 18056341 MGI: J:155042
Larcher F; Del Rio M; Serrano F; Segovia JC; Ramirez A; Meana A; Page A; Abad JL; Gonzalez MA; Bueren J; Bernad A; Jorcano JL. 2001. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J 15(9):1529-38. PubMed: 11427484 MGI: J:115148
Law KM; Komarova NL; Yewdall AW; Lee RK; Herrera OL; Wodarz D; Chen BK. 2016. In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection. Cell Rep 15(12):2771-83. PubMed: 27292632 MGI: J:238305
Lawres LA; Garg A; Kumar V; Bruzual I; Forquer IP; Renard I; Virji AZ; Boulard P; Rodriguez EX; Allen AJ; Pou S; Wegmann KW; Winter RW; Nilsen A; Mao J; Preston DA; Belperron AA; Bockenstedt LK; Hinrichs DJ; Riscoe MK; Doggett JS; Ben Mamoun C. 2016. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. J Exp Med 213(7):1307-18. PubMed: 27270894 MGI: J:236267
Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol 177(10):7076-85. PubMed: 17082624 MGI: J:140484
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. PubMed: 20033053 MGI: J:158026
Lee SM; Yang H; Tartar DM; Gao B; Luo X; Ye SQ; Zaghouani H; Fang D. 2011. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia :. PubMed: 21340626 MGI: J:169586
Lefevre S; Knedla A; Tennie C; Kampmann A; Wunrau C; Dinser R; Korb A; Schnaker EM; Tarner IH; Robbins PD; Evans CH; Sturz H; Steinmeyer J; Gay S; Scholmerich J; Pap T; Muller-Ladner U; Neumann E. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 15(12):1414-20. PubMed: 19898488 MGI: J:155763
Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. PubMed: 3553324 MGI: J:32752
Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. PubMed: 23686485 MGI: J:204842
Li B; Sharpe EE; Maupin AB; Teleron AA; Pyle AL; Carmeliet P; Young PP. 2006. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J 20(9):1495-7. PubMed: 16754748 MGI: J:111344
Li CR; Mueller EE; Bradley LM. 2014. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes. J Immunol 192(4):1425-32. PubMed: 24446517 MGI: J:209355
Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. PubMed: 16365445 MGI: J:126256
Li G; Zhang L; Chen E; Wang J; Jiang X; Chen JH; Wickman G; Amundson K; Bergqvist S; Zobel J; Buckman D; Baxi SM; Bender SL; Casperson GF; Hu-Lowe DD. 2010. Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity. Cancer Res 70(24):10243-54. PubMed: 21159645 MGI: J:167600
Li S; Ling C; Zhong L; Li M; Su Q; He R; Tang Q; Greiner DL; Shultz LD; Brehm MA; Flotte TR; Mueller C; Srivastava A; Gao G. 2015. Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors. Mol Ther 23(12):1867-76. PubMed: 26403887 MGI: J:230567
Li SW; Koya V; Li Y; Donelan W; Lin P; Reeves WH; Yang LJ. 2010. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 90(1):31-9. PubMed: 19901909 MGI: J:156607
Li T; Ramirez K; Palacios R. 1996. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7(1):107-14. PubMed: 8788039 MGI: J:31364
Li X; Sterling JA; Fan KH; Vessella RL; Shyr Y; Hayward SW; Matrisian LM; Bhowmick NA. 2012. Loss of TGF-beta responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res 10(4):494-503. PubMed: 22290877 MGI: J:205394
Li Y; Su J; Dingzhang X; Zhang J; Yoshimoto M; Liu S; Bijian K; Gupta A; Squire JA; Alaoui Jamali MA; Bismar TA. 2011. PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome. J Pathol 224(1):90-100. PubMed: 21381033 MGI: J:171247
Liao MJ; Zhang XX; Hill R; Gao J; Qumsiyeh MB; Nichols W; Van Dyke T. 1998. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol Cell Biol 18(6):3495-501. PubMed: 9584189 MGI: J:47667
Liao YJ; Fang CC; Yen CH; Hsu SM; Wang CK; Huang SF; Liang YC; Lin YY; Chu YT; Arthur Chen YM. 2015. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. Int J Cancer 137(6):1341-51. PubMed: 25754535 MGI: J:222874
Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. PubMed: 20713716 MGI: J:163745
Liebe B; Petukhova G; Barchi M; Bellani M; Braselmann H; Nakano T; Pandita TK; Jasin M; Fornace A; Meistrich ML; Baarends WM; Schimenti J; de Lange T; Keeney S; Camerini-Otero RD; Scherthan H. 2006. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res 312(19):3768-81. PubMed: 17010969 MGI: J:147391
Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. PubMed: 18515407 MGI: J:138638
Lieke T; Steeg C; Graefe SE; Fleischer B; Jacobs T. 2006. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. Clin Exp Immunol 145(2):357-64. PubMed: 16879257 MGI: J:112856
Lin P; Li W; Yao Z; Sun Y; Wang L; Li S; Chen L. 2015. Oral administration of PDX1 confers protection against insulitis in the non-obese diabetic (NOD) mice. Biochem Biophys Res Commun 466(4):656-63. PubMed: 26403969 MGI: J:232937
Liu D; Zhang T; Marshall AJ; Okkenhaug K; Vanhaesebroeck B; Uzonna JE. 2009. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 183(3):1921-33. PubMed: 19596993 MGI: J:151583
Liu R; Liu C; Chen D; Yang WH; Liu X; Liu CG; Dugas CM; Tang F; Zheng P; Liu Y; Wang L. 2015. FOXP3 Controls an miR-146/NF-kappaB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. Cancer Res 75(8):1703-13. PubMed: 25712342 MGI: J:220159
Liu Y; Carlsson R; Comabella M; Wang J; Kosicki M; Carrion B; Hasan M; Wu X; Montalban X; Dziegiel MH; Sellebjerg F; Sorensen PS; Helin K; Issazadeh-Navikas S. 2014. FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS. Nat Med 20(3):272-82. PubMed: 24531377 MGI: J:208760
Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82. PubMed: 17566079 MGI: J:127219
Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105(11):1623-30. PubMed: 10841521 MGI: J:62762
Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73(11):7669-76. PubMed: 16239571 MGI: J:104291
Long AH; Haso WM; Shern JF; Wanhainen KM; Murgai M; Ingaramo M; Smith JP; Walker AJ; Kohler ME; Venkateshwara VR; Kaplan RN; Patterson GH; Fry TJ; Orentas RJ; Mackall CL. 2015. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med 21(6):581-90. PubMed: 25939063 MGI: J:228468
Lou YR; Peng QY; Li T; Medvecky CM; Lin Y; Shih WJ; Conney AH; Shapses S; Wagner GC; Lu YP. 2011. Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 32(7):1078-84. PubMed: 21525235 MGI: J:173643
Lu L; Ghose AK; Quail MR; Albom MS; Durkin JT; Holskin BP; Angeles TS; Meyer SL; Ruggeri BA; Cheng M. 2009. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Biochemistry 48(16):3600-9. PubMed: 19249873 MGI: J:149248
Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. PubMed: 19481135 MGI: J:151435
Lucas S; Taront S; Magnan C; Fauconnier L; Delacre M; Macia L; Delanoye A; Verwaerde C; Spriet C; Saule P; Goormachtigh G; Heliot L; Ktorza A; Movassat J; Polakowska R; Auriault C; Poulain-Godefroy O; Di Santo J; Froguel P; Wolowczuk I. 2012. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 7(6):e40351. PubMed: 22768283 MGI: J:187900
Lukacs RU; Memarzadeh S; Wu H; Witte ON. 2010. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7(6):682-93. PubMed: 21112563 MGI: J:168487
Luo X; Tarbell KV; Yang H; Pothoven K; Bailey SL; Ding R; Steinman RM; Suthanthiran M. 2007. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 104(8):2821-6. PubMed: 17307871 MGI: J:125908
MacKenzie DA; Sollinger HW; Hullett DA. 1996. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse. Transplantation 61(10):1461-4. PubMed: 8633371 MGI: J:33268
Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. PubMed: 20472832 MGI: J:164541
Maeda K; Nagasawa H; Furukawa A; Hisaeda H; Himeno K. 1994. Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells. Int Immunol 6(8):1213-9. PubMed: 7981149 MGI: J:22574
Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. PubMed: 9530156 MGI: J:46553
Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. PubMed: 18371405 MGI: J:142413
Majumder M; Xin X; Liu L; Tutunea-Fatan E; Rodriguez-Torres M; Vincent K; Postovit LM; Hess D; Lala PK. 2016. COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis. Stem Cells 34(9):2290-305. PubMed: 27301070 MGI: J:238376
Mamalaki C; Elliott J; Norton T; Yannoutsos N; Townsend AR; Chandler P; Simpson E; Kioussis D. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 3(3):159-74. PubMed: 8281031 MGI: J:113713
Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. PubMed: 18984741 MGI: J:146982
Manis JP; Dudley D; Kaylor L; Alt FW. 2002. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16(4):607-17. PubMed: 11970883 MGI: J:113521
Manuel JA; Gawronska-Kozak B. 2006. Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 25(8):505-14. PubMed: 17010584 MGI: J:116052
Marigo I; Zilio S; Desantis G; Mlecnik B; Agnellini AH; Ugel S; Sasso MS; Qualls JE; Kratochvill F; Zanovello P; Molon B; Ries CH; Runza V; Hoves S; Bilocq AM; Bindea G; Mazza EM; Bicciato S; Galon J; Murray PJ; Bronte V. 2016. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell 30(3):377-90. PubMed: 27622331 MGI: J:234978
Marino E; Walters SN; Villanueva JE; Richards JL; Mackay CR; Grey ST. 2014. BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice. Eur J Immunol 44(4):983-93. PubMed: 24435807 MGI: J:209374
Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. PubMed: 12361980 MGI: J:109851
Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. PubMed: 22072769 MGI: J:179389
Masaki T; Qu J; Cholewa-Waclaw J; Burr K; Raaum R; Rambukkana A. 2013. Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Cell 152(1-2):51-67. PubMed: 23332746 MGI: J:214507
Matsuoka K; Saito M; Shibata K; Sekine M; Shitara H; Taya C; Zhang X; Takahashi TA; Kohno K; Kikkawa Y; Yonekawa H. 2013. Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Biochem Biophys Res Commun 436(3):400-5. PubMed: 23747725 MGI: J:204420
Maykel J; Liu JH; Li H; Shultz LD; Greiner DL; Houghton J. 2014. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci 59(6):1169-79. PubMed: 24798995 MGI: J:227975
McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72(10):5807-13. PubMed: 15385481 MGI: J:93131
McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. PubMed: 20404133 MGI: J:162809
McIntosh BE; Brown ME; Duffin BM; Maufort JP; Vereide DT; Slukvin II; Thomson JA. 2015. Nonirradiated NOD,B6.SCID Il2rgamma(-/-)Kit(W41/W41) (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells. Stem Cell Reports 4(2):171-80. PubMed: 25601207 MGI: J:218738
Mehta S; Huillard E; Kesari S; Maire CL; Golebiowski D; Harrington EP; Alberta JA; Kane MF; Theisen M; Ligon KL; Rowitch DH; Stiles CD. 2011. The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma. Cancer Cell 19(3):359-71. PubMed: 21397859 MGI: J:169930
Meissner N; Swain S; McInnerney K; Han S; Harmsen AG. 2010. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice. Am J Pathol 176(6):2806-18. PubMed: 20395428 MGI: J:161163
Meissner NN; Swain S; Tighe M; Harmsen A; Harmsen A. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174(9):5462-71. PubMed: 15843544 MGI: J:98407
Miller RD; Hogg J; Ozaki JH; Gell D; Jackson SP; Riblet R. 1995. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A 92(23):10792-5. PubMed: 7479885 MGI: J:29679
Mishra A; Brown AL; Yao X; Yang S; Park SJ; Liu C; Dagur PK; McCoy JP; Keeran KJ; Nugent GZ; Jeffries KR; Qu X; Yu ZX; Levine SJ; Chung JH. 2015. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun 6:6224. PubMed: 25692509 MGI: J:221358
Mishra R; Chen AT; Welsh RM; Szomolanyi-Tsuda E. 2010. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog 6(5):e1000924. PubMed: 20523894 MGI: J:162921
Mizrahi K; Stein J; Pearl-Yafe M; Kaplan O; Yaniv I; Askenasy N. 2010. Regulatory functions of TRAIL in hematopoietic progenitors: human umbilical cord blood and murine bone marrow transplantation. Leukemia 24(7):1325-34. PubMed: 20485377 MGI: J:162490
Montecino-Rodriguez E; Leathers H; Dorshkind K. 2006. Identification of a B-1 B cell-specified progenitor. Nat Immunol 7(3):293-301. PubMed: 16429139 MGI: J:112481
Monteiro JP; Benjamin A; Costa ES; Barcinski MA; Bonomo A. 2005. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood 105(4):1484-91. PubMed: 15514013 MGI: J:96600
Morris SC; Heidorn SM; Herbert DR; Perkins C; Hildeman DA; Khodoun MV; Finkelman FD. 2009. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. J Immunol 182(3):1429-38. PubMed: 19155490 MGI: J:144327
Morrison C; Smith GC; Stingl L; Jackson SP; Wagner EF; Wang ZQ. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 17(4):479-82. PubMed: 9398855 MGI: J:75374
Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL. 1993. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177(1):191-4. PubMed: 8418200 MGI: J:3479
Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. PubMed: 19535452 MGI: J:153922
Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. PubMed: 22791816 MGI: J:192954
Mutwiri G K; Kosecka U; Benjamin M; Rosendal S; Perdue M; Butler D G. 2001. Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice. Comp Med 51(6):538-44. PubMed: 11924817 MGI: J:73720
Nacht M; Strasser A; Chan YR; Harris AW; Schlissel M; Bronson RT; Jacks T. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev 10(16):2055-66. PubMed: 8769648 MGI: J:35055
Nakayama M; Beilke JN; Jasinski JM; Kobayashi M; Miao D; Li M; Coulombe MG; Liu E; Elliott JF; Gill RG; Eisenbarth GS. 2007. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest 117(7):1835-43. PubMed: 17607359 MGI: J:124210
Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. PubMed: 20805496 MGI: J:164365
Nemoto Y; Kanai T; Takahara M; Oshima S; Okamoto R; Tsuchiya K; Matsumoto S; Watanabe M. 2013. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J Immunol 190(12):6616-25. PubMed: 23670188 MGI: J:204854
Niimi N; Sugo N; Aratani Y; Koyama H. 2005. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ 12(2):184-91. PubMed: 15647757 MGI: J:106364
Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. PubMed: 11884426 MGI: J:126867
Nonaka S; Naito T; Chen H; Yamamoto M; Moro K; Kiyono H; Hamada H; Ishikawa H. 2005. Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol 174(4):1906-12. PubMed: 15699117 MGI: J:96579
Nonoyama S; Smith FO; Bernstein ID; Ochs HD. 1993. Strain-dependent leakiness of mice with severe combined immune deficiency. J Immunol 150(9):3817-24. PubMed: 8473734 MGI: J:4610
Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 177(11):7715-22. PubMed: 17114442 MGI: J:140848
Notley CA; Inglis JJ; Alzabin S; McCann FE; McNamee KE; Williams RO. 2008. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205(11):2491-7. PubMed: 18936235 MGI: J:140651
Nucera S; Giustacchini A; Boccalatte F; Calabria A; Fanciullo C; Plati T; Ranghetti A; Garcia-Manteiga J; Cittaro D; Benedicenti F; Lechman ER; Dick JE; Ponzoni M; Ciceri F; Montini E; Gentner B; Naldini L. 2016. miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia. Cancer Cell 29(6):905-21. PubMed: 27300437 MGI: J:232327
O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. PubMed: 22392992 MGI: J:182231
O'Hara JR; Skinn AC; MacNaughton WK; Sherman PM; Sharkey KA. 2006. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 8(4):646-60. PubMed: 16548890 MGI: J:135756
O'Malley JT; Eri RD; Stritesky GL; Mathur AN; Chang HC; Hogenesch H; Srinivasan M; Kaplan MH. 2008. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol 181(7):5062-70. PubMed: 18802110 MGI: J:142733
O'Reilly LA; Harris AW; Strasser A. 1997. bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors. Int Immunol 9(9):1291-301. PubMed: 9310832 MGI: J:93122
O'Reilly LA; Harris AW; Tarlinton DM; Corcoran LM; Strasser A. 1997. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. J Immunol 159(5):2301-11. PubMed: 9278319 MGI: J:93123
Ochiai M; Ubagai T; Kawamori T; Imai H; Sugimura T; Nakagama H. 2001. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. Carcinogenesis 22(9):1551-5. PubMed: 11532879 MGI: J:84343
Ohsugi T; Kiuchi Y; Shimoda K; Oguri S; Maejima K. 1996. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim 30(1):46-50. PubMed: 8709573 MGI: J:31261
Oida T; Suzuki K; Nanno M; Kanamori Y; Saito H; Kubota E; Kato S; Itoh M; Kaminogawa S; Ishikawa H. 2000. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. J Immunol 164(7):3616-26. PubMed: 10725718 MGI: J:112139
Okada K; Shoda J; Taguchi K; Maher JM; Ishizaki K; Inoue Y; Ohtsuki M; Goto N; Takeda K; Utsunomiya H; Oda K; Warabi E; Ishii T; Osaka K; Hyodo I; Yamamoto M. 2008. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol 295(4):G735-47. PubMed: 18687751 MGI: J:142149
Okazaki T; Okazaki IM; Wang J; Sugiura D; Nakaki F; Yoshida T; Kato Y; Fagarasan S; Muramatsu M; Eto T; Hioki K; Honjo T. 2011. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med 208(2):395-407. PubMed: 21300912 MGI: J:176845
Okazuka K; Wakabayashi Y; Kashihara M; Inoue J; Sato T; Yokoyama M; Aizawa S; Aizawa Y; Mishima Y; Kominami R. 2005. p53 prevents maturation of T cell development to the immature CD4(-)CD8(+) stage in Bcl11b(-/-) mice. Biochem Biophys Res Commun 328(2):545-549. PubMed: 15694382 MGI: J:96179
Omori K; Mitsuhashi M; Ishiyama K; Nair I; Rawson J; Todorov I; Kandeel F; Mullen Y. 2011. mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-alpha-induced islet damage in humans. Diabetologia 54(8):2056-66. PubMed: 21567299 MGI: J:175299
Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice. Infect Immun 81(11):4252-60. PubMed: 24002064 MGI: J:201876
Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. PubMed: 22430210 MGI: J:193369
Oruganti SR; Torres DJ; Krebsbach S; Asperti-Boursin F; Winters J; Matlawska-Wasowska K; Winter SS; Halsey C; Cannon JL. 2017. CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia 31(1):255-258. PubMed: 27698445 MGI: J:237842
Osmond DG; Kim N; Manoukian R; Phillips RA; Rico-Vargas SA; Jacobsen K. 1992. Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice. Blood 79(7):1695-703. PubMed: 1373084 MGI: J:737
Owyang AM; Zaph C; Wilson EH; Guild KJ; McClanahan T; Miller HR; Cua DJ; Goldschmidt M; Hunter CA; Kastelein RA; Artis D. 2006. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 203(4):843-9. PubMed: 16606667 MGI: J:123808
Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. PubMed: 19447681 MGI: J:151452
Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med 191(4):731-6. PubMed: 10684864 MGI: J:112016
Paliwal P; Conboy IM. 2011. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18(9):1153-66. PubMed: 21944754 MGI: J:190199
Pancewicz J; Taylor JM; Datta A; Baydoun HH; Waldmann TA; Hermine O; Nicot C. 2010. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci U S A 107(38):16619-24. PubMed: 20823234 MGI: J:164350
Papagiannakopoulos T; Friedmann-Morvinski D; Neveu P; Dugas JC; Gill RM; Huillard E; Liu C; Zong H; Rowitch DH; Barres BA; Verma IM; Kosik KS. 2012. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene 31(15):1884-95. PubMed: 21874051 MGI: J:186143
Papeta N; Zheng Z; Schon EA; Brosel S; Altintas MM; Nasr SH; Reiser J; D'Agati VD; Gharavi AG. 2010. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest 120(11):4055-64. PubMed: 20978358 MGI: J:166909
Park CW; Ryu HW; Ryu KY. 2012. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun 418(3):541-6. PubMed: 22285186 MGI: J:181255
Park JS; Kim IK; Han S; Park I; Kim C; Bae J; Oh SJ; Lee S; Kim JH; Woo DC; He Y; Augustin HG; Kim I; Lee D; Koh GY. 2016. Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment. Cancer Cell 30(6):953-967. PubMed: 27960088 MGI: J:238058
Pathania R; Ramachandran S; Elangovan S; Padia R; Yang P; Cinghu S; Veeranan-Karmegam R; Arjunan P; Gnana-Prakasam JP; Sadanand F; Pei L; Chang CS; Choi JH; Shi H; Manicassamy S; Prasad PD; Sharma S; Ganapathy V; Jothi R; Thangaraju M. 2015. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. Nat Commun 6:6910. PubMed: 25908435 MGI: J:222799
Pathania R; Ramachandran S; Mariappan G; Thakur P; Shi H; Choi JH; Manicassamy S; Kolhe R; Prasad PD; Sharma S; Lokeshwar BL; Ganapathy V; Thangaraju M. 2016. Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth. Cancer Res 76(11):3224-35. PubMed: 27197203 MGI: J:232034
Pauza ME; Dobbs CM; He J; Patterson T; Wagner S; Anobile BS; Bradley BJ; Lo D; Haskins K. 2004. T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes 53(4):978-88. PubMed: 15047613 MGI: J:89082
Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. PubMed: 18491294 MGI: J:151386
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. PubMed: 18563383 MGI: J:138005
Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. PubMed: 18785974 MGI: J:140388
Pedraza-Alva G; Koulnis M; Charland C; Thornton T; Clements JL; Schlissel MS; Rincon M. 2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J 25(4):763-73. PubMed: 16456545 MGI: J:105987
Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. PubMed: 22340590 MGI: J:181463
Percy DH; Auger DC; Croy BA. 1994. Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice. Vet Pathol 31(1):67-73. PubMed: 8140728 MGI: J:17913
Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. PubMed: 8320959 MGI: J:4752
Perone MJ; Bertera S; Tawadrous ZS; Shufesky WJ; Piganelli JD; Baum LG; Trucco M; Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177(8):5278-89. PubMed: 17015713 MGI: J:139444
Petitto JM; Huang Z; Lo J; Streit WJ. 2003. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol 134(1-2):95-103. PubMed: 12507776 MGI: J:105891
Phillips JM; Parish NM; Drage M; Cooke A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunol 167(11):6087-91. PubMed: 11714766 MGI: J:119045
Pierce EM; Carpenter K; Jakubzick C; Kunkel SL; Flaherty KR; Martinez FJ; Hogaboam CM. 2007. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 170(4):1152-64. PubMed: 17392156 MGI: J:120124
Pierce MA; Chapman HD; Post CM; Svetlanov A; Efrat S; Horwitz M; Serreze DV. 2003. Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes 52(5):1119-27. PubMed: 12716741 MGI: J:83195
Plenter RJ; Grazia TJ; Nelson DP; Zamora MR; Gill RG; Pietra BA. 2015. Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection. Cell Immunol 293(1):30-3. PubMed: 25497973 MGI: J:223254
Porubsky S; Wang S; Kiss E; Dehmel S; Bonrouhi M; Dorn T; Luckow B; Brakebusch C; Grone HJ. 2011. Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection. Eur J Immunol 41(1):76-88. PubMed: 21182079 MGI: J:174659
Powrie F; Leach MW; Mauze S; Menon S; Caddle LB; Coffman RL. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1(7):553-62. PubMed: 7600284 MGI: J:133778
Prochazka M; Gaskins HR; Shultz LD; Leiter EH. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A 89(8):3290-4. PubMed: 1373493 MGI: J:513
Purwana I; Zheng J; Li X; Deurloo M; Son DO; Zhang Z; Liang C; Shen E; Tadkase A; Feng ZP; Li Y; Hasilo C; Paraskevas S; Bortell R; Greiner DL; Atkinson M; Prud'homme GJ; Wang Q. 2014. GABA promotes human beta-cell proliferation and modulates glucose homeostasis. Diabetes 63(12):4197-205. PubMed: 25008178 MGI: J:230144
Qing Y; Lin Y; Gerson SL. 2012. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood 119(7):1768-71. PubMed: 22147896 MGI: J:181738
Qualls JE; Kaplan AM; van Rooijen N; Cohen DA. 2006. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 80(4):802-15. PubMed: 16888083 MGI: J:113033
Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. PubMed: 19052619 MGI: J:142408
Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. PubMed: 22542847 MGI: J:184798
Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. PubMed: 21209895 MGI: J:168312
Rauner G; Leviav A; Mavor E; Barash I. 2013. Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice. PLoS One 8(6):e68637. PubMed: 23825700 MGI: J:204342
Read TA; Fogarty MP; Markant SL; McLendon RE; Wei Z; Ellison DW; Febbo PG; Wechsler-Reya RJ. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15(2):135-47. PubMed: 19185848 MGI: J:144811
Riggs J; Stowers R. 1996. Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice. Immunology 88(1):20-7. PubMed: 8707345 MGI: J:32916
Riggs JE; Feeney AJ; Kirven M; Mosier DE. 1994. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer. Mol Immunol 31(11):783-91. PubMed: 8047070 MGI: J:19789
Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. J Immunol 191(6):2865-9. PubMed: 23960238 MGI: J:205867
Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73(2):1141-50. PubMed: 15664957 MGI: J:95620
Roberts JL; Abe R; Shores EW; Singer A. 1992. Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. J Immunol 149(5):1577-82. PubMed: 1506683 MGI: J:2072
Rochford R; Ohrt C; Baresel PC; Campo B; Sampath A; Magill AJ; Tekwani BL; Walker LA. 2013. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proc Natl Acad Sci U S A 110(43):17486-91. PubMed: 24101478 MGI: J:201977
Rodgers JT; King KY; Brett JO; Cromie MJ; Charville GW; Maguire KK; Brunson C; Mastey N; Liu L; Tsai CR; Goodell MA; Rando TA. 2014. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature 510(7505):393-6. PubMed: 24870234 MGI: J:213273
Rolink A; Melchers F; Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5(4):319-30. PubMed: 8885865 MGI: J:36026
Rosario CO; Ko MA; Haffani YZ; Gladdy RA; Paderova J; Pollett A; Squire JA; Dennis JW; Swallow CJ. 2010. Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A 107(15):6888-93. PubMed: 20348415 MGI: J:159310
Rosen C; Shezen E; Aronovich A; Klionsky YZ; Yaakov Y; Assayag M; Biton IE; Tal O; Shakhar G; Ben-Hur H; Shneider D; Vaknin Z; Sadan O; Evron S; Freud E; Shoseyov D; Wilschanski M; Berkman N; Fibbe WE; Hagin D; Hillel-Karniel C; Krentsis IM; Bachar-Lustig E; Reisner Y. 2015. Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice. Nat Med 21(8):869-79. PubMed: 26168294 MGI: J:228759
Roths JB; Smith AL; Sidman CL. 1993. Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice. J Exp Med 177(4):1193-8. PubMed: 8459214 MGI: J:109921
Rotolo JA; Mesicek J; Maj J; Truman JP; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2010. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70(3):957-67. PubMed: 20086180 MGI: J:156862
Roy N; Takeuchi KK; Ruggeri JM; Bailey P; Chang D; Li J; Leonhardt L; Puri S; Hoffman MT; Gao S; Halbrook CJ; Song Y; Ljungman M; Malik S; Wright CV; Dawson DW; Biankin AV; Hebrok M; Crawford HC. 2016. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev 30(24):2669-2683. PubMed: 28087712 MGI: J:238701
Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun 76(5):2130-7. PubMed: 18332204 MGI: J:134470
Ruetsch NR; Bosma GC; Bosma MJ. 2000. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med 191(11):1933-43. PubMed: 10839808 MGI: J:62701
Rui J; Deng S; Lebastchi J; Clark PL; Usmani-Brown S; Herold KC. 2016. Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Diabetologia 59(5):1021-9. PubMed: 26910463 MGI: J:232925
Rynda-Apple A; Dobrinen E; McAlpine M; Read A; Harmsen A; Richert LE; Calverley M; Pallister K; Voyich J; Wiley JA; Johnson B; Young M; Douglas T; Harmsen AG. 2012. Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function. Am J Pathol 181(1):196-210. PubMed: 22642909 MGI: J:185523
Saeed H; Abdallah BM; Ditzel N; Catala-Lehnen P; Qiu W; Amling M; Kassem M. 2011. Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. J Bone Miner Res 26(7):1494-505. PubMed: 21308778 MGI: J:233117
Sakai D; Nakamura Y; Nakai T; Mishima T; Kato S; Grad S; Alini M; Risbud MV; Chan D; Cheah KS; Yamamura K; Masuda K; Okano H; Ando K; Mochida J. 2012. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun 3:1264. PubMed: 23232394 MGI: J:225067
Salem ML; Al-Khami AA; El-Naggar SA; Diaz-Montero CM; Chen Y; Cole DJ. 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol 184(4):1737-47. PubMed: 20083664 MGI: J:159482
Samy ET; Meyer CA; Caplazi P; Langrish CL; Lora JM; Bluethmann H; Peng SL. 2007. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. J Immunol 179(9):5644-8. PubMed: 17947634 MGI: J:153014
Sandri S; Bobisse S; Moxley K; Lamolinara A; De Sanctis F; Boschi F; Sbarbati A; Fracasso G; Ferrarini G; Hendriks RW; Cavallini C; Scupoli MT; Sartoris S; Iezzi M; Nishimura MI; Bronte V; Ugel S. 2016. Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies. Cancer Res 76(9):2540-51. PubMed: 27197263 MGI: J:232028
Santidrian AF; Matsuno-Yagi A; Ritland M; Seo BB; LeBoeuf SE; Gay LJ; Yagi T; Felding-Habermann B. 2013. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123(3):1068-81. PubMed: 23426180 MGI: J:196392
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76(1):97-102. PubMed: 17967861 MGI: J:130296
Savinov AY; Rozanov DV; Strongin AY. 2007. Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice. J Biol Chem 282(44):32106-11. PubMed: 17761671 MGI: J:126809
Savinov AY; Tcherepanov A; Green EA; Flavell RA; Chervonsky AV. 2003. Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A 100(2):628-32. PubMed: 12525697 MGI: J:81416
Savouret C; Brisson E; Essers J; Kanaar R; Pastink A; te Riele H; Junien C; Gourdon G. 2003. CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J 22(9):2264-73. PubMed: 12727892 MGI: J:83373
Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol 16(12):1238-48. PubMed: 25362351 MGI: J:217693
Schito ML; Barta JR. 1997. Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice. Infect Immun 65(8):3165-70. PubMed: 9234770 MGI: J:41839
Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am J Pathol 163(5):2077-91. PubMed: 14578206 MGI: J:86318
Schon MP; Schon M; Warren HB; Donohue JP; Parker CM. 2000. Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice. J Immunol 165(11):6583-9. PubMed: 11086102 MGI: J:110810
Schroder PM; Khattar M; Baum CE; Miyahara Y; Chen W; Vyas R; Muralidharan S; Mierzejewska B; Stepkowski SM. 2015. PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRbeta mAb therapy. Diabetologia 58(6):1309-18. PubMed: 25794782 MGI: J:220839
Schuler W; Weiler IJ; Schuler A; Phillips RA; Rosenberg N; Mak TW; Kearney JF; Perry RP; Bosma MJ. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46(7):963-72. PubMed: 3093081 MGI: J:8420
Searles S; Gauss K; Wilkison M; Hoyt TR; Dobrinen E; Meissner N. 2013. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection. J Immunol 191(7):3884-95. PubMed: 23975863 MGI: J:205844
Seehus CR; Aliahmad P; de la Torre B; Iliev ID; Spurka L; Funari VA; Kaye J. 2015. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol 16(6):599-608. PubMed: 25915732 MGI: J:232838
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. PubMed: 19636062 MGI: J:152910
Sekiguchi J; Ferguson DO; Chen HT; Yang EM; Earle J; Frank K; Whitlow S; Gu Y; Xu Y; Nussenzweig A; Alt FW. 2001. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 98(6):3243-8. PubMed: 11248063 MGI: J:68074
Sela U; Olds P; Park A; Schlesinger SJ; Steinman RM. 2011. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med 208(12):2489-96. PubMed: 22084406 MGI: J:178615
Serpe CJ; Kohm AP; Huppenbauer CB; Sanders VM; Jones KJ. 1999. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice. J Neurosci 19(11):RC7. PubMed: 10341268 MGI: J:120563
Serre L; Fazilleau N; Guerder S. 2015. Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice. Eur J Immunol 45(7):1946-56. PubMed: 25884569 MGI: J:229782
Serreze DV; Chapman HD; Varnum DS; Gerling I; Leiter EH; Shultz LD. 1997. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol 158(8):3978-86. PubMed: 9103469 MGI: J:39473
Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. PubMed: 11522664 MGI: J:71050
Serreze DV; Leiter EH; Hanson MS; Christianson SW; Shultz LD; Hesselton RM; Greiner DL. 1995. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. Diabetes 44(12):1392-8. PubMed: 7589844 MGI: J:29951
Severe S; Gauvrit A; Vu AT; Bach JM. 2007. CD8(+) T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD(SCID) mouse. Mol Immunol 44(11):2950-60. PubMed: 17336387 MGI: J:119811
Sewald X; Ladinsky MS; Uchil PD; Beloor J; Pi R; Herrmann C; Motamedi N; Murooka TT; Brehm MA; Greiner DL; Shultz LD; Mempel TR; Bjorkman PJ; Kumar P; Mothes W. 2015. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science 350(6260):563-7. PubMed: 26429886 MGI: J:226540
Shang L; Hua H; Foo K; Martinez H; Watanabe K; Zimmer M; Kahler DJ; Freeby M; Chung W; LeDuc C; Goland R; Leibel RL; Egli D. 2014. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63(3):923-33. PubMed: 24227685 MGI: J:208989
Shellito JE; Kolls JK; Olariu R; Beck JM. 1996. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 173(2):432-9. PubMed: 8568306 MGI: J:31163
Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Uetsuka K ; Nakayama H ; Doi K. 1997. SCID-bg mice as xenograft recipients. Lab Anim 31(2):163-8. PubMed: 9175014 MGI: J:40569
Shoji S; Watanabe H; Katoh O; Masaoka Y; Matsuura S; Tauchi H; Endo S; Komatsu K. 1998. Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol 73(6):705-9. PubMed: 9690689 MGI: J:51083
Shores EW; Nakayama T; Wiest DL; Takahama Y; Sharrow S; Singer A. 1993. Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene. J Immunol 150(4):1263-75. PubMed: 8094405 MGI: J:111476
Shukla A; Rai K; Shukla V; Chaturvedi NK; Bociek RG; Pirruccello SJ; Band H; Lu R; Joshi SS. 2016. Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL. Blood 127(19):2310-21. PubMed: 26809508 MGI: J:232635
Shultz LD; Banuelos S; Lyons B; Samuels R; Burzenski L; Gott B; Lang P; Leif J; Appel M; Rossini A; Greiner DL. 2003. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation 76(7):1036-42. PubMed: 14557749 MGI: J:109843
Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. PubMed: 17259968 MGI: J:142414
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. PubMed: 15879151 MGI: J:109833
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. PubMed: 20615947 MGI: J:162315
Shultz LD; Schweitzer PA; Christianson SW; Gott B; Schweitzer IB; Tennent B; McKenna S; Mobraaten L; Rajan TV; Greiner DL; Leiter EH. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154(1):180-91. PubMed: 7995938 MGI: J:22026
Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res 69(6):2487-96. PubMed: 19276376 MGI: J:147072
Simard C; Klein SJ; Mak T; Jolicoeur P. 1997. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus. J Virol 71(4):3013-22. PubMed: 9060661 MGI: J:38897
Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55. PubMed: 22960283 MGI: J:190538
Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. PubMed: 18453623 MGI: J:142412
Smith AA; Li J; Liu B; Hunter D; Pyles M; Gillette M; Dhamdhere GR; Abo A; Oro A; Helms JA. 2016. Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth. J Invest Dermatol 136(8):1549-58. PubMed: 27109869 MGI: J:235025
Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165(2):1022-9. PubMed: 10878379 MGI: J:120556
Song X; Guo Y; Duo S; Che J; Wu C; Ochiya T; Ding M; Deng H. 2009. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol 175(5):1975-83. PubMed: 19808649 MGI: J:154703
Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. PubMed: 22371883 MGI: J:183769
Stalder AK; Carson MJ; Pagenstecher A; Asensio VC; Kincaid C; Benedict M; Powell HC; Masliah E; Campbell IL. 1998. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am J Pathol 153(3):767-83. PubMed: 9736027 MGI: J:106595
Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 296(3):H689-97. PubMed: 19112095 MGI: J:146361
Stone JL; McMillan RE; Skaar DA; Bradshaw JM; Jirtle RL; Sikes ML. 2012. DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dbeta2 Germline Transcription in Developing Thymocytes. J Immunol 188(5):2266-75. PubMed: 22287717 MGI: J:181246
Stracker TH; Couto SS; Cordon-Cardo C; Matos T; Petrini JH. 2008. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31(1):21-32. PubMed: 18614044 MGI: J:138550
Stracker TH; Williams BR; Deriano L; Theunissen JW; Adelman CA; Roth DB; Petrini JH. 2009. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol 29(2):503-14. PubMed: 19015239 MGI: J:144749
Strasser A; Harris AW; Corcoran LM; Cory S. 1994. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368(6470):457-60. PubMed: 8133891 MGI: J:17426
Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. PubMed: 23643966 MGI: J:202381
Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. PubMed: 20671122 MGI: J:167434
Su MA; Davini D; Cheng P; Giang K; Fan U; DeVoss JJ; Johannes KP; Taylor L; Shum AK; Valenzise M; Meloni A; Bour-Jordan H; Anderson MS. 2012. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol 188(10):4906-12. PubMed: 22490868 MGI: J:188686
Su X; Hu Q; Kristan JM; Costa C; Shen Y; Gero D; Matis LA; Wang Y. 2000. Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol 164(5):2523-32. PubMed: 10679090 MGI: J:127009
Suffia I; Reckling SK; Salay G; Belkaid Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol 174(9):5444-55. PubMed: 15845457 MGI: J:98414
Sugiarto S; Persson AI; Munoz EG; Waldhuber M; Lamagna C; Andor N; Hanecker P; Ayers-Ringler J; Phillips J; Siu J; Lim DA; Vandenberg S; Stallcup W; Berger MS; Bergers G; Weiss WA; Petritsch C. 2011. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328-40. PubMed: 21907924 MGI: J:175969
Sugiura K; Taketani S; Yoshimura T; Nishino T; Nishino N; Fujisawa J; Hisha H; Inaba T; Ikehara S. 2007. Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice. Cytokine 37(3):218-26. PubMed: 17512212 MGI: J:126823
Sun X; Robertson SA; Ingman WV. 2013. Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland. Cytokine 61(2):377-88. PubMed: 23290315 MGI: J:197873
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. MGI: J:30359
Sundberg JP; Adkison DL; Bedigian HG. 1991. Skeletal muscle rhabdomyosarcomas in inbred laboratory mice. Vet Pathol 28(3):200-6. PubMed: 1830433 MGI: J:24311
Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. PubMed: 20634377 MGI: J:165866
Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. PubMed: 24361497 MGI: J:206386
Szomolanyi-Tsuda E; Dundon PL; Joris I; Shultz LD; Woda BA; Welsh RM. 1994. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol 144(2):359-71. PubMed: 8311119 MGI: J:16875
Ta VB; de Haan AB; de Bruijn MJ; Dingjan GM; Hendriks RW. 2011. Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity. Leukemia 25(1):48-56. PubMed: 21030983 MGI: J:167638
Tadokoro Y; Ema H; Okano M; Li E; Nakauchi H. 2007. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 204(4):715-22. PubMed: 17420264 MGI: J:125606
Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. PubMed: 22279057 MGI: J:180274
Takahama Y; Sugaya K; Tsuda S; Hasegawa T; Hashimoto Y. 1995. Regulation of early T cell development by the engagement of TCR-beta complex expressed on fetal thymocytes from TCR-beta-transgenic scid mice. J Immunol 154(11):5862-9. PubMed: 7751632 MGI: J:25533
Takahashi Y; Inamine A; Hashimoto S; Haraguchi S; Yoshioka E; Kojima N; Abe R; Takemori T. 2005. Novel role of the Ras cascade in memory B cell response. Immunity 23(2):127-38. PubMed: 16111632 MGI: J:100532
Takata M; Nakagomi T; Kashiwamura S; Nakano-Doi A; Saino O; Nakagomi N; Okamura H; Mimura O; Taguchi A; Matsuyama T. 2012. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ 19(5):756-67. PubMed: 22052192 MGI: J:203071
Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12):1313-23. PubMed: 17982459 MGI: J:127760
Takeuchi D; Jones VC; Kobayashi M; Suzuki F. 2008. Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum. Infect Immun 76(8):3657-63. PubMed: 18519557 MGI: J:139362
Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. PubMed: 22611244 MGI: J:188959
Thayer TC; Delano M; Liu C; Chen J; Padgett LE; Tse HM; Annamali M; Piganelli JD; Moldawer LL; Mathews CE. 2011. Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes 60(8):2144-51. PubMed: 21715554 MGI: J:186804
The Jackson Laboratory. 2005. Information obtained from The Jackson Laboratory, Bar Harbor, ME Unpublished :. MGI: J:101977
Thomas DC; Mellanby RJ; Phillips JM; Cooke A. 2007. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology 121(4):565-76. PubMed: 17437531 MGI: J:125536
Todorova D; Kim J; Hamzeinejad S; He J; Xu Y. 2016. Brief Report: Immune Microenvironment Determines the Immunogenicity of Induced Pluripotent Stem Cell Derivatives. Stem Cells 34(2):510-5. PubMed: 26439188 MGI: J:233079
Touvrey C; Couedel C; Soulas P; Couderc R; Jasin M; de Villartay JP; Marche PN; Jouvin-Marche E; Candeias SM. 2008. Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol 45(12):3383-91. PubMed: 18501428 MGI: J:137712
Tremblay AM; Missiaglia E; Galli GG; Hettmer S; Urcia R; Carrara M; Judson RN; Thway K; Nadal G; Selfe JL; Murray G; Calogero RA; De Bari C; Zammit PS; Delorenzi M; Wagers AJ; Shipley J; Wackerhage H; Camargo FD. 2014. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell 26(2):273-87. PubMed: 25087979 MGI: J:214602
Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. PubMed: 16968775 MGI: J:113717
Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. PubMed: 23740949 MGI: J:205347
Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32(4):568-80. PubMed: 20381385 MGI: J:179859
Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171(10):5507-13. PubMed: 14607957 MGI: J:106734
Tsuji H; Ishii-Ohba H; Noda Y; Kubo E; Furuse T; Tatsumi K. 2009. Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice. Mutat Res 660(1-2):22-32. PubMed: 19000702 MGI: J:144042
Tsuji Y; Watanabe T; Kudo M; Arai H; Strober W; Chiba T. 2012. Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis. Immunity 37(2):326-38. PubMed: 22902233 MGI: J:187368
Tucker TA; Kundert JA; Bondareva AA; Schmidt EE. 2005. Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background. Immunogenetics 57(3-4):226-31. PubMed: 15900494 MGI: J:98496
Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. PubMed: 16317068 MGI: J:104385
Ueno S; Lu J; He J; Li A; Zhang X; Ritz J; Silberstein LE; Chai L. 2014. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol 42(4):307-316.e8. PubMed: 24463278 MGI: J:215705
Uhlig HH; McKenzie BS; Hue S; Thompson C; Joyce-Shaikh B; Stepankova R; Robinson N; Buonocore S; Tlaskalova-Hogenova H; Cua DJ; Powrie F. 2006. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25(2):309-18. PubMed: 16919486 MGI: J:113470
Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. PubMed: 19369639 MGI: J:151270
Van Buul PP; De Rooij DG; Zandman IM; Grigorova M; Van Duyn-Goedhart A. 1995. X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse. Int J Radiat Biol 67(5):549-55. PubMed: 7775830 MGI: J:26914
VanBuskirk KM; O'Neill MT; De La Vega P; Maier AG; Krzych U; Williams J; Dowler MG; Sacci JB Jr; Kangwanrangsan N; Tsuboi T; Kneteman NM; Heppner DG Jr; Murdock BA; Mikolajczak SA; Aly AS; Cowman AF; Kappe SH. 2009. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A 106(31):13004-9. PubMed: 19625622 MGI: J:152010
Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB. 2014. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26(1):33-47. PubMed: 24954133 MGI: J:213713
Vemuri MC; Schiller E; Naegele JR. 2001. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ 8(3):245-55. PubMed: 11319607 MGI: J:115402
Verma-Gandhu M; Bercik P; Motomura Y; Verdu EF; Khan WI; Blennerhassett PA; Wang L; El-Sharkawy RT; Collins SM. 2006. CD4+ T-cell modulation of visceral nociception in mice. Gastroenterology 130(6):1721-8. PubMed: 16697736 MGI: J:124915
Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. PubMed: 21875955 MGI: J:177573
Viret C; Leung-Theung-Long S; Serre L; Lamare C; Vignali DA; Malissen B; Carrier A; Guerder S. 2011. Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice. J Clin Invest 121(5):1810-21. PubMed: 21505262 MGI: J:173941
Viriyakosol S; Matthias MA; Swancutt MA; Kirkland TN; Vinetz JM. 2006. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun 74(2):887-95. PubMed: 16428731 MGI: J:105019
Volkmann A; Doffinger R; Ruther U; Kyewski BA. 1996. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis. J Immunol 156(1):136-45. PubMed: 8598454 MGI: J:108193
Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. PubMed: 20430958 MGI: J:162797
Waldner H; Sobel RA; Price N; Kuchroo VK. 2006. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol 176(9):5455-62. PubMed: 16622013 MGI: J:131655
Walzer PD; Runck J; Steele P; White M; Linke MJ; Sidman CL. 1997. Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs. Antimicrob Agents Chemother 41(2):251-8. PubMed: 9021175 MGI: J:39028
Wang C; Bogue MA; Levitt JM; Roth DB. 1999. Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells. J Exp Med 190(9):1257-62. PubMed: 10544197 MGI: J:115093
Wang GY; So PL; Wang L; Libove E; Wang J; Epstein EH Jr. 2011. Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. J Invest Dermatol 131(11):2298-305. PubMed: 21833014 MGI: J:182174
Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. PubMed: 18684934 MGI: J:140188
Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. PubMed: 24516154 MGI: J:206819
Wang P; Rodriguez RT; Wang J; Ghodasara A; Kim SK. 2011. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell 8(3):335-46. PubMed: 21362573 MGI: J:171124
Wang Y; Sul HS. 2009. Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9. Cell Metab 9(3):287-302. PubMed: 19254573 MGI: J:147095
Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice. Am J Pathol 146(4):1017-24. PubMed: 7717446 MGI: J:24415
Wecker H; Grusby MJ; Auchincloss H Jr. 1995. Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation 59(8):1223-7. PubMed: 7732570 MGI: J:25110
Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6):483-95. PubMed: 18538732 MGI: J:166360
Wei S; Kozono S; Kats L; Nechama M; Li W; Guarnerio J; Luo M; You MH; Yao Y; Kondo A; Hu H; Bozkurt G; Moerke NJ; Cao S; Reschke M; Chen CH; Rego EM; Lo-Coco F; Cantley LC; Lee TH; Wu H; Zhang Y; Pandolfi PP; Zhou XZ; Lu KP. 2015. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med 21(5):457-66. PubMed: 25849135 MGI: J:228245
Westwell-Roper C; Dai DL; Soukhatcheva G; Potter KJ; van Rooijen N; Ehses JA; Verchere CB. 2011. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 187(5):2755-65. PubMed: 21813778 MGI: J:179268
White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. PubMed: 22406538 MGI: J:184554
Wicklein D; Schmidt A; Labitzky V; Ullrich S; Valent P; Schumacher U. 2013. E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. PLoS One 8(7):e70139. PubMed: 23922938 MGI: J:204363
Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. PubMed: 12370382 MGI: J:109850
Wilkison M; Gauss K; Ran Y; Searles S; Taylor D; Meissner N. 2012. Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection. Am J Pathol 181(1):151-62. PubMed: 22626807 MGI: J:185537
Willimann K; Matile H; Weiss NA; Imhof BA. 1995. In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria. J Exp Med 182(3):643-53. PubMed: 7650476 MGI: J:28277
Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect Immun 66(8):3892-9. PubMed: 9673277 MGI: J:48876
Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. PubMed: 15983204 MGI: J:109830
Woods NB; Bottero V; Schmidt M; von Kalle C; Verma IM. 2006. Gene therapy: therapeutic gene causing lymphoma. Nature 440(7088):1123. PubMed: 16641981 MGI: J:108380
Wu T; Sun C; Chen Z; Zhen Y; Peng J; Qi Z; Yang X; Zhao Y. 2012. Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway. J Immunol 189(10):4989-5000. PubMed: 23045614 MGI: J:190588
Wu X; Zhang W; Font-Burgada J; Palmer T; Hamil AS; Biswas SK; Poidinger M; Borcherding N; Xie Q; Ellies LG; Lytle NK; Wu LW; Fox RG; Yang J; Dowdy SF; Reya T; Karin M. 2014. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A 111(38):13870-5. PubMed: 25189770 MGI: J:216379
Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL. 2015. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells 33(2):468-78. PubMed: 25329668 MGI: J:223580
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF. 2016. Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma. Cancer Res 76(23):6901-6910. PubMed: 27634757 MGI: J:237854
Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. PubMed: 21576322 MGI: J:175272
XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. PubMed: 19805087 MGI: J:153698
Yahata T; Ando K; Nakamura Y; Ueyama Y; Shimamura K; Tamaoki N; Kato S; Hotta T. 2002. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 169(1):204-9. PubMed: 12077246 MGI: J:77239
Yamasaki H; Sada A; Iwata T; Niwa T; Tomizawa M; Xanthopoulos KG; Koike T; Shiojiri N. 2006. Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133(21):4233-43. PubMed: 17021047 MGI: J:114400
Yamashita J; Iwamura C; Ito T; Narita M; Hara Y; Sasaki T; Masuda D; Takahashi M; Tsuchiya M; Hada K; Ishikawa M; Matsuo T; Ohno Y; Tanaka H; Maruyama H; Ogawa Y; Nakayama T. 2013. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-gamma production from CD4 T cells. J Immunol 191(2):949-60. PubMed: 23772025 MGI: J:204816
Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. PubMed: 17982083 MGI: J:154010
Yang C; Loehn M; Jurczyk A; Przewozniak N; Leehy L; Herrera PL; Shultz LD; Greiner DL; Harlan DM; Bortell R. 2015. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes 8:387-98. PubMed: 26316789 MGI: J:225120
Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol 186(2):1259-67. PubMed: 21169553 MGI: J:168755
Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. PubMed: 21724588 MGI: J:175446
Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74(4):1022-31. PubMed: 24356421 MGI: J:208172
Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. PubMed: 20080755 MGI: J:156523
Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y. 2013. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proc Natl Acad Sci U S A 110(34):13932-7. PubMed: 23918367 MGI: J:200676
Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. PubMed: 10809058 MGI: J:94302
Yasuda A; Tsuji O; Shibata S; Nori S; Takano M; Kobayashi Y; Takahashi Y; Fujiyoshi K; Hara CM; Miyawaki A; Okano HJ; Toyama Y; Nakamura M; Okano H. 2011. Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord. Stem Cells 29(12):1983-94. PubMed: 22028197 MGI: J:190194
Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus. J Immunol 158(10):4729-33. PubMed: 9144486 MGI: J:40207
Yeh ES; Lew BO; Means AR. 2006. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem 281(1):241-51. PubMed: 16223725 MGI: J:105781
Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes 61(5):1180-91. PubMed: 22403295 MGI: J:196728
Yi Z; Diz R; Martin AJ; Morillon YM; Kline DE; Li L; Wang B; Tisch R. 2012. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes 61(11):2871-80. PubMed: 22751694 MGI: J:208520
Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol 42(8):2010-8. PubMed: 22865049 MGI: J:187880
Yoshida K; van den Berg TK; Dijkstra CD. 1994. The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes. Eur J Immunol 24(2):464-8. PubMed: 8299696 MGI: J:16866
Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. PubMed: 23348745 MGI: J:194482
Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes. J Vet Med Sci 56(2):415-6. PubMed: 8075241 MGI: J:21177
Young D; Kearney JF. 1995. Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice. Int Immunol 7(5):807-19. PubMed: 7547707 MGI: J:25547
Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. PubMed: 15494484 MGI: J:132809
Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol 188(7):3009-18. PubMed: 22351938 MGI: J:183110
Zare F; Bokarewa M; Nenonen N; Bergstrom T; Alexopoulou L; Flavell RA; Tarkowski A. 2004. Arthritogenic properties of double-stranded (viral) RNA. J Immunol 172(9):5656-63. PubMed: 15100310 MGI: J:89689
Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. PubMed: 20382848 MGI: J:161539
Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. PubMed: 20478526 MGI: J:160523
Zhang C; Cui Y; Houston S; Chang LJ. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc Natl Acad Sci U S A 93(25):14720-5. PubMed: 8962121 MGI: J:37253
Zhang H; Hilton MJ; Anolik JH; Welle SL; Zhao C; Yao Z; Li X; Wang Z; Boyce BF; Xing L. 2014. NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest 124(7):3200-14. PubMed: 24892805 MGI: J:213803
Zhang H; Watanabe R; Berry GJ; Vaglio A; Liao YJ; Warrington KJ; Goronzy JJ; Weyand CM. 2017. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Proc Natl Acad Sci U S A 114(6):E970-E979. PubMed: 28115719 MGI: J:240876
Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. PubMed: 21368761 MGI: J:170816
Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. PubMed: 15583018 MGI: J:94696
Zhang Q; Hossain DM; Duttagupta P; Moreira D; Zhao X; Won H; Buettner R; Nechaev S; Majka M; Zhang B; Cai Q; Swiderski P; Kuo YH; Forman S; Marcucci G; Kortylewski M. 2016. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood 127(13):1687-700. PubMed: 26796361 MGI: J:232638
Zhang S; Yajima H; Huynh H; Zheng J; Callen E; Chen HT; Wong N; Bunting S; Lin YF; Li M; Lee KJ; Story M; Gapud E; Sleckman BP; Nussenzweig A; Zhang CC; Chen DJ; Chen BP. 2011. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 193(2):295-305. PubMed: 21482716 MGI: J:171351
Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. PubMed: 20668064 MGI: J:164245
Zhang YW; Su Y; Lanning N; Gustafson M; Shinomiya N; Zhao P; Cao B; Tsarfaty G; Wang LM; Hay R; Vande Woude GF. 2005. Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor. Oncogene 24(1):101-6. PubMed: 15531925 MGI: J:239806
Zhao C; Marrero I; Narsale A; Moya R; Davies JD. 2015. CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells. Cell Immunol 296(2):106-14. PubMed: 25910642 MGI: J:229768
Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. PubMed: 20691153 MGI: J:164900
Zheng CF; Guan KL. 1993. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem 268(15):11435-9. PubMed: 8388392 MGI: J:31929
Zheng M; Ramsay AJ; Robichaux MB; Norris KA; Kliment C; Crowe C; Rapaka RR; Steele C; McAllister F; Shellito JE; Marrero L; Schwarzenberger P; Zhong Q; Kolls JK. 2005. CD4+ T cell-independent DNA vaccination against opportunistic infections. J Clin Invest 115(12):3536-44. PubMed: 16308571 MGI: J:104584
Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165(10):5580-7. PubMed: 11067913 MGI: J:119580
Zhu C; Roth DB. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2(1):101-12. PubMed: 7600297 MGI: J:28349
de Laval B; Pawlikowska P; Petit-Cocault L; Bilhou-Nabera C; Aubin-Houzelstein G; Souyri M; Pouzoulet F; Gaudry M; Porteu F. 2013. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell 12(1):37-48. PubMed: 23246483 MGI: J:194947
de Oliveira VL; Keijsers RR; van de Kerkhof PC; Seyger MM; Fasse E; Svensson L; Latta M; Norsgaard H; Labuda T; Hupkens P; van Erp PE; Joosten I; Koenen HJ. 2012. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells. PLoS One 7(10):e45509. PubMed: 23094018 MGI: J:192181
van Buul PP; Abramsson-Zetterberg L; Zandman IM; van Duyn-Goedhart A. 1998. Further characterization of the radiosensitivity of the scid mouse. Int J Radiat Biol 74(1):35-41. PubMed: 9687973 MGI: J:115137
van Essen D; Dullforce P; Gray D. 2000. Role of B cells in maintaining helper T-cell memory. Philos Trans R Soc Lond B Biol Sci 355(1395):351-5. PubMed: 10794053 MGI: J:106317
van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. PubMed: 16239576 MGI: J:104292
van den Pol AN. 2009. Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient. J Virol 83(1):420-7. PubMed: 18945784 MGI: J:153392
van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. PubMed: 23690475 MGI: J:204834
von Herrath MG; Dockter J; Oldstone MB. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1(3):231-42. PubMed: 7889411 MGI: J:81287

Additional - Tg(CMV-IL3,CSF2,KITLG)1Eav related

Bruedigam C; Bagger FO; Heidel FH; Paine Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee E; Riyat S; Moore AS; Lock RB; Bullinger L; Hill GR; Armstrong SA; Williams DA; Lane SW. 2014. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell 15(6):775-90. PubMed: 25479751 MGI: J:223853
Nicolini FE; Cashman JD; Hogge DE; Humphries RK; Eaves CJ. 2004. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 18(2):341-7. PubMed: 14628073 MGI: J:87755
Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6):483-95. PubMed: 18538732 MGI: J:166360
Wunderlich M; Brooks RA; Panchal R; Rhyasen GW; Danet-Desnoyers G; Mulloy JC. 2014. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood 123(24):e134-44. PubMed: 24778156 MGI: J:217446

QUANTITY	VOLUME PRICING
Volume pricing is not available for Domestic Commercial & For-Profit.

Quantity	Volume Pricing
Volume pricing is not available for International Commercial & For-Profit.

Also Known As: NOD-scid IL2Rgnull-3/GM/SF, NSG-SGM3, NSGS

Donating Investigator

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Selected References

Il2rgtm1Wjl

Allele Symbol: Il2rgtm1Wjl

Prkdcscid

Allele Symbol: Prkdcscid

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Symbol: Tg(CMV-IL3,CSF2,KITLG)1Eav

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Il2rgtm1Wjl related

Genotype: Prkdcscid related

Phenotype Information

References

Additional - Il2rgtm1Wjl related

Additional - Prkdcscid related

Additional - Tg(CMV-IL3,CSF2,KITLG)1Eav related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Animal Health Reports

Live Mouse

Volume Pricing Details

Domestic Commercial & For-Profit

Domestic Not-For-Profit & Academic

International Commercial & For-Profit

International Not-For-Profit & Academic

Cryorecovery - Pricing

Progeny testing is not required

RELATED PRODUCTS AND SERVICES

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Il2rg^tm1Wjl related

Genotype: Prkdc^scid related

Additional - Il2rg^tm1Wjl related

Additional - Prkdc^scid related