JAX Mouse Strain Datasheet - 013062

NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ

Stock No:: 013062 |; NSG-SGM3

Readily Available

Overview

Also Known As: NOD-scid IL2Rgnull-3/GM/SF, NSG-SGM3, NSGS

The triple transgenic NSG-SGM3 (NSGS) mice expressing human IL3, GM-CSF and SCF combine the features of the highly immunodeficient NOD scid gamma (NSG) mouse with cytokines that support the stable engraftment of myeloid lineages and regulatory T cell populations. As a result, these NSG-SGM3 mice allow superior engraftment of diverse hematopoietic lineages and primary AML samples than other models and are useful for immuno-oncology, immunology and infectious disease studies.

Donating Investigator

James C Mulloy, Cincinnati Children's Hospital Medical Center

Genetic overview

Genetic Background	Generation
	N12+N1F4pF3p (17-NOV-15)

Il2rg^tm1Wjl

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Il2rg	interleukin 2 receptor, gamma chain

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

View Genetics

Research Applications

Cancer Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Research Tools
Virology Research

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Base Price

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$245.00 Domestic price for male 3-week

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Details

Detailed Description

These mice contain three coinjected transgenes, human interleukin-3 (IL-3), human granulocyte/macrophage-stimulating factor (GM-CSF), and human Steel factor (SF) gene, each driven by a human cytomegalovirus promoter/enhancer sequence. These mice are maintained on the NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice (Stock No. 005557) background. These mice constitutively produce 2-4 ng/ml serum levels of human IL-3, GM-CSF, and SF. The Il2rg-/- specific NOD.SCID background supports human and murine hematopoietic cell engraftment, and suppresses human erythropoiesis, enhances human myelopoiesis, and reduces human B-lymphopoiesis in mice after transplant of bone marrow or liver cells.

View Flow Cytometry Characterization Data for Immunodeficient JAX Strains

Development

Three separate transgenes were designed each carrying either the human interleukin-3 (IL-3) gene, the human granulocyte/macrophage-stimulating factor (GM-CSF) gene, or human Steel factor (SF) gene. Expression of each gene is driven by a human cytomegalovirus promoter/enhancer sequence, and is followed by a human growth hormone cassette and a polyadenylation (polyA) sequence. The transgenes were microinjected into fertilized C57BL/6xC3H/HeN oocytes. The resulting founders, carrying all three transgenes (3GS) were backcrossed to BALB/c-scid/scid mice for several generations and subsequently backcrossed to NOD.CB17-Prkdc^scid mice for at least 11 generations. These mice were bred to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl mice, and were then interbred until all offspring were homozygous for 3GS and the IL2rg targeted mutation. Upon arrival at The Jackson Laboratory, transgenic mice were bred to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice (Stock No. 005557) for one generation to establish the colony. Thereafter, females homozygous for Prkdc^scid, homozygous for Il2rg^tm1Wjl and homozygous for the 3GS transgenes were bred with males homozygous for Prkdc^scid, hemizygous for the X-linked Il2rg^tm1Wjl and homozygous for the 3GS transgenes.

Expression Data

Expressed Gene	CSF2, colony stimulating factor 2, human
Expressed Gene	IL3, interleukin 3, human
Expressed Gene	KITLG, KIT ligand, human
Site of Expression

Control Suggestions

Additional Information

Considerations for Choosing Controls

Selected References

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice.. In: . . MGI: J:170510
Bryce PJ; Falahati R; Kenney LL; Leung J; Bebbington C; Tomasevic N; Krier RA; Hsu CL; Shultz LD; Greiner DL; Brehm MA. 2016. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.. In: . . MGI: J:231799
Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain.. In: . . MGI: J:230785
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.. In: . . MGI: J:166359

View All References

Genetics

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Allele Name	targeted mutation 1, Warren J Leonard
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	CD132^-; IL2Rgamma^null; Il2rg^tm1Wjll; [KO]gammac; gammac^-; gc^-
Gene Symbol and Name	Il2rg, interleukin 2 receptor, gamma chain
Gene Synonym(s)	Ab2-183; CD132; CIDX; Cd132; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gammaC; gc
Site of Expression	Primarily lymphoid cells.
Strain of Origin	129S4/SvJae
Chromosome	X
Molecular Note	A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein.
Mutations Made By	Dr. Warren Leonard, NHLBI, NIH

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Symbol: Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Name	transgene insertion 1, CJ Eaves
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	3/GM/SF; SGM3; Tg(hSCF/hGM-CSF/hIL3
Gene Symbol and Name	Tg(CMV-IL3,CSF2,KITLG)1Eav, transgene insertion 1, CJ Eaves
Gene Synonym(s)	3/GM/SF
Promoter	CMV, cytomegalovirus, human
Expressed Gene	CSF2, colony stimulating factor 2, human
Expressed Gene	IL3, interleukin 3, human
Expressed Gene	KITLG, KIT ligand, human
Strain of Origin	(C57BL/6 x C3H/HeN)F1
Chromosome	UN
Molecular Note	cDNAs encoding human interleukin 3, colony stimulating factor 2 (granulocyte-macrophage) and kit ligand were independently ligated into expression cassettes in which the cDNA resides downstream of the cytomegalovirus (CMV) promoter/enhancer sequence and is followed by human growth factor intronic and polyadenylation sequences. A transgenic mouse that was shown by ELISA to have serum levels of all three growth factors at ng/ml levels was used to establish a line with the same phenotype.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Il2rg^tm1Wjl related

Cancer Research
- Growth Factors/Receptors/Cytokines
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Phenotype Information

Body Weight Information - JAX® Mice Strain - NOD.Cg-Prkdc^scidIl2rg^tm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ

References

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice.. In: . . MGI: J:170510
Bryce PJ; Falahati R; Kenney LL; Leung J; Bebbington C; Tomasevic N; Krier RA; Hsu CL; Shultz LD; Greiner DL; Brehm MA. 2016. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.. In: . . MGI: J:231799
Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain.. In: . . MGI: J:230785
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.. In: . . MGI: J:166359

Additional - Il2rg^tm1Wjl related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.. In: . . MGI: J:226625
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.. In: . . MGI: J:142410
Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes.. In: . . MGI: J:174292
Al-Shami A; Spolski R; Kelly J; Fry T; Schwartzberg PL; Pandey A; Mackall CL; Leonard WJ. 2004. A role for thymic stromal lymphopoietin in CD4(+) T cell development.. In: . . MGI: J:108209
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype.. In: . . MGI: J:191672
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.. In: . . MGI: J:224046
Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells.. In: . . MGI: J:163262
Arpke RW; Darabi R; Mader TL; Zhang Y; Toyama A; Lonetree CL; Nash N; Lowe DA; Perlingeiro RC; Kyba M. 2013. A New Immuno- Dystrophin-Deficient Model, the NSG-Mdx Mouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation.. In: . . MGI: J:199729
Ashkar AA; Black GP; Wei Q; He H; Liang L; Head JR; Croy BA. 2003. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.. In: . . MGI: J:85375
Aspord C; Tramcourt L; Leloup C; Molens JP; Leccia MT; Charles J; Plumas J. 2014. Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization.. In: . . MGI: J:214771
Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo.. In: . . MGI: J:180174
Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge.. In: . . MGI: J:190812
Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis.. In: . . MGI: J:204234
Barclay SL; Yang Y; Zhang S; Fong R; Barraza A; Nolta JA; Torbett BE; Abedi M; Bauer G; Anderson JS. 2015. Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells.. In: . . MGI: J:223977
Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.. In: . . MGI: J:172780
Bayer AL; Lee JY; de la Barrera A; Surh CD; Malek TR. 2008. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.. In: . . MGI: J:137409
Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.. In: . . MGI: J:206976
Bertilaccio MT; Simonetti G; Dagklis A; Rocchi M; Rodriguez TV; Apollonio B; Mantovani A; Ponzoni M; Ghia P; Garlanda C; Caligaris-Cappio F; Muzio M. 2011. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models.. In: . . MGI: J:174861
Bezman NA; Chakraborty T; Bender T; Lanier LL. 2011. miR-150 regulates the development of NK and iNKT cells.. In: . . MGI: J:179053
Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice.. In: . . MGI: J:205706
Blaisdell A; Crequer A; Columbus D; Daikoku T; Mittal K; Dey SK; Erlebacher A. 2015. Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.. In: . . MGI: J:227408
Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.. In: . . MGI: J:191833
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.. In: . . MGI: J:167433
Borel F; Tang Q; Gernoux G; Greer C; Wang Z; Barzel A; Kay MA; Schultz LD; Greiner DL; Flotte TR; Brehm MA; Mueller C. 2017. Survival advantage of both human hepatocyte xenografts and genome editedhepatocytes for treatment of alpha-1 antitrypsin deficiency. In: . . MGI: J:243726
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Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF.. In: . . MGI: J:180273
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Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.. In: . . MGI: J:194620
Bunker JJ; Flynn TM; Koval JC; Shaw DG; Meisel M; McDonald BD; Ishizuka IE; Dent AL; Wilson PC; Jabri B; Antonopoulos DA; Bendelac A. 2015. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.. In: . . MGI: J:233653
Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.. In: . . MGI: J:141932
Cao X; Shores EW; Hu-Li J; Anver MR; Kelsall BL; Russell SM; Drago J; Noguchi M; Grinberg A; Bloom ET; Paul WE; Katz SI; Love PE; Leonard WJ. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.. In: . . MGI: J:24117
Castiglioni A; Corna G; Rigamonti E; Basso V; Vezzoli M; Monno A; Almada AE; Mondino A; Wagers AJ; Manfredi AA; Rovere-Querini P. 2015. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration.. In: . . MGI: J:237716
Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion.. In: . . MGI: J:210438
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Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors.. In: . . MGI: J:155800
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Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.. In: . . MGI: J:237848
Clemente-Casares X; Blanco J; Ambalavanan P; Yamanouchi J; Singha S; Fandos C; Tsai S; Wang J; Garabatos N; Izquierdo C; Agrawal S; Keough MB; Yong VW; James E; Moore A; Yang Y; Stratmann T; Serra P; Santamaria P. 2016. Expanding antigen-specific regulatory networks to treat autoimmunity.. In: . . MGI: J:229667
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.. In: . . MGI: J:196312
Constantinides MG; Gudjonson H; McDonald BD; Ishizuka IE; Verhoef PA; Dinner AR; Bendelac A. 2015. PLZF expression maps the early stages of ILC1 lineage development.. In: . . MGI: J:220811
Constantinides MG; McDonald BD; Verhoef PA; Bendelac A. 2014. A committed precursor to innate lymphoid cells.. In: . . MGI: J:205609
Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development.. In: . . MGI: J:112393
Cosgun KN; Rahmig S; Mende N; Reinke S; Hauber I; Schafer C; Petzold A; Weisbach H; Heidkamp G; Purbojo A; Cesnjevar R; Platz A; Bornhauser M; Schmitz M; Dudziak D; Hauber J; Kirberg J; Waskow C. 2014. Kit regulates HSC engraftment across the human-mouse species barrier.. In: . . MGI: J:232320
Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells.. In: . . MGI: J:200896
Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.. In: . . MGI: J:177904
Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?. In: . . MGI: J:142178
Czuczman NM; Barth MJ; Gu J; Neppalli V; Mavis C; Frys SE; Hu Q; Liu S; Klener P; Vockova P; Czuczman MS; Hernandez-Ilizaliturri FJ. 2016. Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo.. In: . . MGI: J:232593
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.. In: . . MGI: J:234081
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White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.. In: . . MGI: J:184554
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.. In: . . MGI: J:177952
Wilhelm C; Hirota K; Stieglitz B; Van Snick J; Tolaini M; Lahl K; Sparwasser T; Helmby H; Stockinger B. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.. In: . . MGI: J:177640
Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.. In: . . MGI: J:196378
Wu X; Kastin AJ; Hsuchou H; Pan W. 2010. The effects of IL2Rgamma knockout on depression and contextual memory.. In: . . MGI: J:161861
Wunderlich M; Brooks RA; Panchal R; Rhyasen GW; Danet-Desnoyers G; Mulloy JC. 2014. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.. In: . . MGI: J:217446
Xie H; Xu J; Hsu JH; Nguyen M; Fujiwara Y; Peng C; Orkin SH. 2014. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.. In: . . MGI: J:205522
Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL. 2015. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.. In: . . MGI: J:223580
Xie Y; Akpinarli A; Maris C; Hipkiss EL; Lane M; Kwon EK; Muranski P; Restifo NP; Antony PA. 2010. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.. In: . . MGI: J:158128
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF. 2016. Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma.. In: . . MGI: J:237854
Xu X; Weiss ID; Zhang HH; Singh SP; Wynn TA; Wilson MS; Farber JM. 2014. Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia.. In: . . MGI: J:209361
XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.. In: . . MGI: J:153698
Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival.. In: . . MGI: J:123902
Yamauchi T; Takenaka K; Urata S; Shima T; Kikushige Y; Tokuyama T; Iwamoto C; Nishihara M; Iwasaki H; Miyamoto T; Honma N; Nakao M; Matozaki T; Akashi K. 2013. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.. In: . . MGI: J:194763
Yang C; Loehn M; Jurczyk A; Przewozniak N; Leehy L; Herrera PL; Shultz LD; Greiner DL; Harlan DM; Bortell R. 2015. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.. In: . . MGI: J:225120
Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression.. In: . . MGI: J:175446
Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2.. In: . . MGI: J:208172
Yang Q; Li F; Harly C; Xing S; Ye L; Xia X; Wang H; Wang X; Yu S; Zhou X; Cam M; Xue HH; Bhandoola A. 2015. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.. In: . . MGI: J:233391
Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors.. In: . . MGI: J:194482
Yu G; Xu X; Vu MD; Kilpatrick ED; Li XC. 2006. NK cells promote transplant tolerance by killing donor antigen-presenting cells.. In: . . MGI: J:124395
Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.. In: . . MGI: J:161539
Zecher D; Li Q; Oberbarnscheidt MH; Demetris AJ; Shlomchik WD; Rothstein DM; Lakkis FG. 2010. NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.. In: . . MGI: J:161405
Zemp FJ; McKenzie BA; Lun X; Reilly KM; McFadden G; Yong VW; Forsyth PA. 2014. Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus.. In: . . MGI: J:218088
Zenewicz LA; Yancopoulos GD; Valenzuela DM; Murphy AJ; Stevens S; Flavell RA. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.. In: . . MGI: J:142640
Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.. In: . . MGI: J:160523
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Zhang Q; Hossain DM; Duttagupta P; Moreira D; Zhao X; Won H; Buettner R; Nechaev S; Majka M; Zhang B; Cai Q; Swiderski P; Kuo YH; Forman S; Marcucci G; Kortylewski M. 2016. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.. In: . . MGI: J:232638
Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.. In: . . MGI: J:164245
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van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells.. In: . . MGI: J:204834

Additional - Prkdc^scid related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.. In: . . MGI: J:226625
Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.. In: . . MGI: J:164507
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.. In: . . MGI: J:142410
Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma.. In: . . MGI: J:22989
Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.. In: . . MGI: J:107507
Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.. In: . . MGI: J:110480
Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.. In: . . MGI: J:94366
Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.. In: . . MGI: J:142215
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype.. In: . . MGI: J:191672
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.. In: . . MGI: J:125443
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.. In: . . MGI: J:224046
Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.. In: . . MGI: J:112102
Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival.. In: . . MGI: J:188666
Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.. In: . . MGI: J:108737
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer.. In: . . MGI: J:178597
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.. In: . . MGI: J:134670
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice.. In: . . MGI: J:122426
Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells.. In: . . MGI: J:163262
Araki R; Fujimori A; Hamatani K; Mita K; Saito T; Mori M; Fukumura R; Morimyo M; Muto M; Itoh M; Tatsumi K; Abe M. 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.. In: . . MGI: J:39329
Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.. In: . . MGI: J:199531
Arendt LM; McCready J; Keller PJ; Baker DD; Naber SP; Seewaldt V; Kuperwasser C. 2013. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.. In: . . MGI: J:202607
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Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.. In: . . MGI: J:49819
Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo.. In: . . MGI: J:180174
Baker RL; Delong T; Barbour G; Bradley B; Nakayama M; Haskins K. 2013. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice.. In: . . MGI: J:206266
Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes. In: . . MGI: J:66103
Balavenkatraman KK; Aceto N; Britschgi A; Mueller U; Bence KK; Neel BG; Bentires-Alj M. 2011. Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.. In: . . MGI: J:205401
Baleriola J; Suarez T; de la Rosa EJ. 2010. DNA-PK promotes the survival of young neurons in the embryonic mouse retina.. In: . . MGI: J:186357
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Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans.. In: . . MGI: J:173478
Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.. In: . . MGI: J:168235
Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice.. In: . . MGI: J:162610
Banga SS; Hall KT; Sandhu AK; Weaver DT; Athwal RS. 1994. Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8.. In: . . MGI: J:21219
Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.. In: . . MGI: J:91764
Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.. In: . . MGI: J:149592
Barber RC; Miccoli L; van Buul PP; Burr KL; van Duyn-Goedhart A; Angulo JF; Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice.. In: . . MGI: J:93788
Bardeesy N; Kim M; Xu J; Kim RS; Shen Q; Bosenberg MW; Wong WH; Chin L. 2005. Role of epidermal growth factor receptor signaling in RAS-driven melanoma.. In: . . MGI: J:99136
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Benner EJ; Banerjee R; Reynolds AD; Sherman S; Pisarev VM; Tsiperson V; Nemachek C; Ciborowski P; Przedborski S; Mosley RL; Gendelman HE. 2008. Nitrated alpha-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons.. In: . . MGI: J:131300
Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa.. In: . . MGI: J:2117
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Bobbala D; Kandhi R; Chen X; Mayhue M; Bouchard E; Yan J; Knecht H; Barabe F; Ramanathan S; Ilangumaran S. 2016. Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency.. In: . . MGI: J:233962
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Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse.. In: . . MGI: J:6958
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Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL. 2015. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.. In: . . MGI: J:223580
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF. 2016. Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma.. In: . . MGI: J:237854
Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.. In: . . MGI: J:175272
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Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.. In: . . MGI: J:154010
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Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.. In: . . MGI: J:168755
Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression.. In: . . MGI: J:175446
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Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y. 2013. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth.. In: . . MGI: J:200676
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Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus.. In: . . MGI: J:40207
Yeh ES; Lew BO; Means AR. 2006. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.. In: . . MGI: J:105781
Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice.. In: . . MGI: J:196728
Yi Z; Diz R; Martin AJ; Morillon YM; Kline DE; Li L; Wang B; Tisch R. 2012. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies.. In: . . MGI: J:208520
Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.. In: . . MGI: J:187880
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Additional - Tg(CMV-IL3,CSF2,KITLG)1Eav related

Bruedigam C; Bagger FO; Heidel FH; Paine Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee E; Riyat S; Moore AS; Lock RB; Bullinger L; Hill GR; Armstrong SA; Williams DA; Lane SW. 2014. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.. In: . . MGI: J:223853
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Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.. In: . . MGI: J:166360
Wunderlich M; Brooks RA; Panchal R; Rhyasen GW; Danet-Desnoyers G; Mulloy JC. 2014. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.. In: . . MGI: J:217446

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Also Known As: NOD-scid IL2Rgnull-3/GM/SF, NSG-SGM3, NSGS

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Il2rgtm1Wjl

Allele Symbol: Il2rgtm1Wjl

Prkdcscid

Allele Symbol: Prkdcscid

Tg(CMV-IL3,CSF2,KITLG)1Eav

Allele Symbol: Tg(CMV-IL3,CSF2,KITLG)1Eav

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Genotype: Il2rgtm1Wjl related

Genotype: Prkdcscid related

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Additional - Prkdcscid related

Additional - Tg(CMV-IL3,CSF2,KITLG)1Eav related

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Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Il2rg^tm1Wjl related

Genotype: Prkdc^scid related

Additional - Il2rg^tm1Wjl related

Additional - Prkdc^scid related