JAX Mouse Strain Datasheet - 005557

NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ

Stock No:: 005557 |; NSG

Readily Available

Overview

Also Known As: NOD scid gamma, NOD-scid IL2Rg^null, NOD-scid IL2Rgamma^null, NSG

These mice are most often referred to using their branded name "NSG™" and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rg^null). The scid mutation is in the DNA repair complex protein Prkdc and renders the mice B and T cell deficient. The IL2rg^null mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient derived xenografts (PDX), or adult stem cells and tissues. The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology.

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Donating Investigator

Dr. Leonard D. Shultz, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
	N8F?+4pF24 (14-AUG-14)

Il2rg^tm1Wjl

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Il2rg	interleukin 2 receptor, gamma chain

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

View Genetics

Research Applications

Research Tools
Cancer Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Virology Research

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Base Price

Starting at:

$170.00 Domestic price for male 3-week

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Details

Important Note

Like its parental strain, NOD/ShiLtJ (Stock No. 001976), NSG mice exhibit a progressive hearing loss that is already severe by three months of age.

Detailed Description

The NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice, most often known by their branded name, NOD scid gamma (NSG™), do not express the Prkdc gene nor the X-linked Il2rg gene. NSG mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Histological examination of lymphoid tissues reveals absence of lymphoid cells and some cystic structures in the thymus, an absence of follicles in the spleen and markedly diminished celluarity of lymph nodes. NSG mice are deficient in mature lymphocytes, serum Ig is not detectable and natural killer (NK) cell cytotoxic activity is extremely low. These mice are resistant to lymphoma development even after sublethal irradiation treatment. These mutant mice have been shown to readily support engraftment of human CD34⁺ hematopoietic stem cells and represent a superior, long-lived model suitable for studies employing xenotransplantation strategies. NSG mice are highly sensitive to the diabetogenic effects of streptozotocin (STZ). The NSG-STZ preclinical model for pancreatic islet transplantation is now available from JAX® Services . Please note that the NSG carries the true null interleukin-2 receptor gamma chain mutation and should not be confused with other strains that express a truncated interleukin-2 receptor gamma chain as described in: "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain" Ohbo K et al. Blood 1996. 87:956-67.

View our Resources for the NSG™ mouse model, including,

NSG™ Mouse Model Portfolio
Housing and Breeding Considerations for NSG™ Mice
Frequently Asked NSG™ Questions
Breakthrough Research Using NSG™
Immunodeficient Mouse and Xenograft Host Comparisons
Flow Cytometry Characterization Data for Immunodeficient JAX Strains

Development

These double mutant mice were produced by breeding female NOD.CB17-Prkdc^scid/J (Stock No. 001303) mice with male mice bearing the X-linked B6.129S4-Il2rg^tm1Wjl/J allele (Stock No. 003174). The resulting male mice heterozygous for the Prkdc^scid allele and hemizygous for the Il2rg^tm1Wjl allele were crossed to female NOD.CB17-Prkdc^scid/J (Stock No. 001303) mice for eight generations. Heterozygotes were interbred to produce mice homozygous for the Prkdc^scid allele and homozygous (females) or hemizygous (males) for the Il2rg^tm1Wjl allele.

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Additional Information

Considerations for Choosing Controls

Selected References

Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain. Stem Cells Dev 25(7):530-41. PubMed: 26879149 MGI: J:230785
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. PubMed: 15879151 MGI: J:109833

View All References

Genetics

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Allele Name	targeted mutation 1, Warren J Leonard
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	CD132^-; IL2Rgamma^null; Il2rg^tm1Wjll; [KO]gammac; gammac^-; gc^-
Gene Symbol and Name	Il2rg, interleukin 2 receptor, gamma chain
Gene Synonym(s)	Ab2-183; CD132; CIDX; Cd132; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gammaC; gc
Site of Expression	Primarily lymphoid cells.
Strain of Origin	129S4/SvJae
Chromosome	X
Molecular Note	A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein.
Mutations Made By	Dr. Warren Leonard, NHLBI, NIH

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - B, T, and NK cell deficiency
- Infectious Disease
  - HIV

Genotype: Il2rg^tm1Wjl related

Cancer Research
- Growth Factors/Receptors/Cytokines
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Mammalian Phenotype Terms by Genotype

Genotype: Il2rg^tm1Wjl/Il2rg^tm1Wjl Prkdc^scid/Prkdc^scid
NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz

mortality/aging

premature death
- median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdc^scid controls
- the majority of autopsies indicate no evidence of lymphomas

immune system phenotype

abnormal immune system organ morphology
- lymph tissues are severely depleted of lymphoid cells

abnormal response to transplant
- human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment
- mice support CD34+ human stem cell engraftment at much higher levels than Prkdc^scid controls

abnormal spleen B cell follicle morphology
- spleens do not have detectable follicles

abnormal splenic cell ratio
- two fold reduction in nucleated spleen cell numbers in comparison to Prkdc^scid controls

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

decreased CD4-positive, alpha beta T cell number
- spleens are deficient in mature T cells

decreased CD8-positive, alpha-beta T cell number
- spleens are deficient in mature T cells

decreased NK cell number
- mice are deficient in cells expressing NK cell markers in comparison to Prkdc^scid controls
- spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity

decreased immature B cell number
- flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdc^scid controls

decreased immunoglobulin level
- no detectable immunoglobulin in mice at 394-426 days of age

decreased leukocyte cell number
- decrease in peripheral leukocytes at 10 weeks as compared to to Prkdc^scid controls

decreased mature B cell number
- spleens are deficient in B220+ IgK+ B cells

lymph node hypoplasia
- lymph nodes are hypocellular

small lymph nodes
- lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdc^scid mice

thymus cysts
- sporadic cyst structures

hematopoietic system phenotype

abnormal spleen B cell follicle morphology
- spleens do not have detectable follicles

abnormal splenic cell ratio
- two fold reduction in nucleated spleen cell numbers in comparison to Prkdc^scid controls

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

decreased CD4-positive, alpha beta T cell number
- spleens are deficient in mature T cells

decreased CD8-positive, alpha-beta T cell number
- spleens are deficient in mature T cells

decreased NK cell number
- mice are deficient in cells expressing NK cell markers in comparison to Prkdc^scid controls
- spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity

decreased immature B cell number
- flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdc^scid controls

decreased immunoglobulin level
- no detectable immunoglobulin in mice at 394-426 days of age

decreased leukocyte cell number
- decrease in peripheral leukocytes at 10 weeks as compared to to Prkdc^scid controls

decreased mature B cell number
- spleens are deficient in B220+ IgK+ B cells

decreased mean corpuscular volume
- slight decrease in packed cell volume at 10 weeks as compared to to Prkdc^scid controls

thymus cysts
- sporadic cyst structures

cellular phenotype

increased cellular sensitivity to X-ray irradiation
- mice do not survive doses above or equal to 400cGy

neoplasm

decreased incidence of tumors by ionizing radiation induction
- mice irradiated with doses below 400cGy do not exhibit thymic lymphomas in contrast to homozygous Prkdc^scid controls

homeostasis/metabolism phenotype

abnormal glucose homeostasis
- streptozotocin-diabetic mice are not restored to euglycemia after receiving transplants of 1000 to 3000 IEQ, while 4000 IEQ transplant was successful in two long-term survivors

hyperglycemia
- streptozotocin effectively induced hyperglycemia essentially equally in male and female mice at doses of 120to 160 mg/kg; some mice do not become hyperglycemic at all doses of streptozotocin administered

endocrine/exocrine gland phenotype

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

thymus cysts
- sporadic cyst structures

Genotype: Il2rg^tm1Wjl/Y Prkdc^scid/Prkdc^scid
NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz

mortality/aging

premature death
- median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdc^scid controls
- the majority of autopsies indicate no evidence of lymphomas

cellular phenotype

increased cellular sensitivity to X-ray irradiation
- mice do not survive doses above or equal to 400cGy

hematopoietic system phenotype

abnormal spleen B cell follicle morphology
- spleens do not have detectable follicles

abnormal splenic cell ratio
- two fold reduction in nucleated spleen cell numbers in comparison to Prkdc^scid controls

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

decreased CD4-positive, alpha beta T cell number
- spleens are deficient in mature T cells

decreased CD8-positive, alpha-beta T cell number
- spleens are deficient in mature T cells

decreased NK cell number
- mice are deficient in cells expressing NK cell markers in comparison to Prkdc^scid controls
- spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity

decreased immature B cell number
- flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdc^scid controls

decreased immunoglobulin level
- no detectable immunoglobulin in mice at 394-426 days of age

decreased leukocyte cell number
- decrease in peripheral leukocytes at 10 weeks as compared to to Prkdc^scid controls

decreased mature B cell number
- spleens are deficient in B220+ IgK+ B cells

decreased mean corpuscular volume
- slight decrease in packed cell volume at 10 weeks as compared to to Prkdc^scid controls

immune system phenotype

abnormal immune system organ morphology
- lymph tissues are severely depleted of lymphoid cells

abnormal response to transplant
- CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.CB17-Prkdc^scid mice
- engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.CB17-Prkdc^scid
- human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment
- irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1^tm1Mom homozygotes
- levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.CB17-Prkdc^scid mice
- mice support CD34+ human stem cell engraftment at much higher levels than Prkdc^scid controls
- percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.CB17-Prkdc^scid mice

abnormal spleen B cell follicle morphology
- spleens do not have detectable follicles

abnormal splenic cell ratio
- two fold reduction in nucleated spleen cell numbers in comparison to Prkdc^scid controls

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

decreased CD4-positive, alpha beta T cell number
- spleens are deficient in mature T cells

decreased CD8-positive, alpha-beta T cell number
- spleens are deficient in mature T cells

decreased NK cell number
- mice are deficient in cells expressing NK cell markers in comparison to Prkdc^scid controls
- spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity

decreased immature B cell number
- flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdc^scid controls

decreased immunoglobulin level
- no detectable immunoglobulin in mice at 394-426 days of age

decreased leukocyte cell number
- decrease in peripheral leukocytes at 10 weeks as compared to to Prkdc^scid controls

decreased mature B cell number
- spleens are deficient in B220+ IgK+ B cells

lymph node hypoplasia
- lymph nodes are hypocellular

small lymph nodes
- lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdc^scid mice

endocrine/exocrine gland phenotype

abnormal thymus morphology
- thymus consists mostly of stromal cells with sporadic cyst structures

Phenotype Information

Body Weight Information - JAX^® Mice Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wyl/SzJ (005557)

JAX^® Physiological Data Summary [pdf]

References

Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain. Stem Cells Dev 25(7):530-41. PubMed: 26879149 MGI: J:230785
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. PubMed: 15879151 MGI: J:109833

Additional References

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. PubMed: 18688847 MGI: J:142410
Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood 115(13):2640-8. PubMed: 20124219 MGI: J:162610
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. PubMed: 20688981 MGI: J:167433
Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A 106(51):21783-8. PubMed: 19966223 MGI: J:155817
Distler E; Wolfel C; Kohler S; Nonn M; Kaus N; Schnurer E; Meyer RG; Wehler TC; Huber C; Wolfel T; Hartwig UF; Herr W. 2008. Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rgamma(null) mice. Exp Hematol 36(4):451-63. PubMed: 18261837 MGI: J:150330
Doulatov S; Notta F; Eppert K; Nguyen LT; Ohashi PS; Dick JE. 2010. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol 11(7):585-93. PubMed: 20543838 MGI: J:162608
Giassi LJ; Pearson T; Shultz LD; Laning J; Biber K; Kraus M; Woda BA; Schmidt MR; Woodland RT; Rossini AA; Greiner DL. 2008. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood) 233(8):997-1012. PubMed: 18653783 MGI: J:150337
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. PubMed: 20671189 MGI: J:162606
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. PubMed: 20495069 MGI: J:161304
Hayakawa J; Hsieh MM; Uchida N; Phang O; Tisdale JF. 2009. Busulfan produces efficient human cell engraftment in NOD/LtSz-Scid IL2Rgamma(null) mice. Stem Cells 27(1):175-82. PubMed: 18927475 MGI: J:150336
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. PubMed: 20068223 MGI: J:162612
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. PubMed: 20601939 MGI: J:162607
Ishikawa F; Niiro H; Iino T; Yoshida S; Saito N; Onohara S; Miyamoto T; Minagawa H; Fujii S; Shultz LD; Harada M; Akashi K. 2007. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood 110(10):3591-660. PubMed: 17664352 MGI: J:150332
Ishikawa F; Saito Y; Yoshida S; Harada M; Shultz LD. 2008. The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. Curr Top Microbiol Immunol 324:87-94. PubMed: 18481454 MGI: J:151387
Ishikawa F; Shimazu H; Shultz LD; Fukata M; Nakamura R; Lyons B; Shimoda K; Shimoda S; Kanemaru T; Nakamura K; Ito H; Kaji Y; Perry AC; Harada M. 2006. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J 20(7):950-2. PubMed: 16585061 MGI: J:150333
Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. PubMed: 15920010 MGI: J:142411
Ishikawa F; Yoshida S; Saito Y; Hijikata A; Kitamura H; Tanaka S; Nakamura R; Tanaka T; Tomiyama H; Saito N; Fukata M; Miyamoto T; Lyons B; Ohshima K; Uchida N; Taniguchi S; Ohara O; Akashi K; Harada M; Shultz LD. 2007. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25(11):1315-21. PubMed: 17952057 MGI: J:150331
Jaiswal S; Jamieson CH; Pang WW; Park CY; Chao MP; Majeti R; Traver D; van Rooijen N; Weissman IL. 2009. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138(2):271-85. PubMed: 19632178 MGI: J:151391
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. PubMed: 19802382 MGI: J:154110
Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. PubMed: 20072130 MGI: J:162611
King M; Pearson T; Rossini AA; Shultz LD; Greiner DL. 2008. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci 1150:46-53. PubMed: 19120266 MGI: J:151393
King M; Pearson T; Shultz LD; Leif J; Bottino R; Trucco M; Atkinson MA; Wasserfall C; Herold KC; Woodland RT; Schmidt MR; Woda BA; Thompson MJ; Rossini AA; Greiner DL. 2008. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 126(3):303-14. PubMed: 18096436 MGI: J:131635
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. PubMed: 19659776 MGI: J:151390
Kong Y; Yoshida S; Saito Y; Doi T; Nagatoshi Y; Fukata M; Saito N; Yang SM; Iwamoto C; Okamura J; Liu KY; Huang XJ; Lu DP; Shultz LD; Harada M; Ishikawa F. 2008. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 22(6):1207-13. PubMed: 18418410 MGI: J:150329
Koo GC; Hasan A; O'Reilly RJ. 2009. Use of humanized severe combined immunodeficient mice for human vaccine development. Expert Rev Vaccines 8(1):113-20. PubMed: 19093778 MGI: J:151535
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. PubMed: 18691745 MGI: J:142409
Lepus CM; Gibson TF; Gerber SA; Kawikova I; Szczepanik M; Hossain J; Ablamunits V; Kirkiles-Smith N; Herold KC; Donis RO; Bothwell AL; Pober JS; Harding MJ. 2009. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Hum Immunol 70(10):790-802. PubMed: 19524633 MGI: J:156922
Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. PubMed: 20713716 MGI: J:163745
Liu C; Chen BJ; Deoliveira D; Sempowski GD; Chao NJ; Storms RW. 2010. Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. Blood 116(25):5518-27. PubMed: 20833978 MGI: J:167432
Majeti R; Chao MP; Alizadeh AA; Pang WW; Jaiswal S; Gibbs KD Jr; van Rooijen N; Weissman IL. 2009. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138(2):286-99. PubMed: 19632179 MGI: J:151392
Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. PubMed: 18371405 MGI: J:142413
Marodon G; Desjardins D; Mercey L; Baillou C; Parent P; Manuel M; Caux C; Bellier B; Pasqual N; Klatzmann D. 2009. High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice. Eur J Immunol 39(8):2136-45. PubMed: 19572320 MGI: J:156921
Maykel J; Liu JH; Li H; Shultz LD; Greiner DL; Houghton J. 2014. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci 59(6):1169-79. PubMed: 24798995 MGI: J:227975
Medyouf H; Gao X; Armstrong F; Gusscott S; Liu Q; Gedman AL; Matherly LH; Schultz KR; Pflumio F; You MJ; Weng AP. 2010. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood 115(6):1175-84. PubMed: 20008304 MGI: J:157729
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Also Known As: NOD scid gamma, NOD-scid IL2Rgnull, NOD-scid IL2Rgammanull, NSG

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Il2rgtm1Wjl

Allele Symbol: Il2rgtm1Wjl

Prkdcscid

Allele Symbol: Prkdcscid

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Genotype: Il2rgtm1Wjl related

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Genotype: Il2rgtm1Wjl/Il2rgtm1Wjl Prkdcscid/PrkdcscidNOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

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Genotype: Il2rgtm1Wjl/Y Prkdcscid/PrkdcscidNOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

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Also Known As: NOD scid gamma, NOD-scid IL2Rg^null, NOD-scid IL2Rgamma^null, NSG

Il2rg^tm1Wjl

Allele Symbol: Il2rg^tm1Wjl

Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Il2rg^tm1Wjl related

Genotype: Prkdc^scid related

Genotype: Il2rg^tm1Wjl/Il2rg^tm1Wjl Prkdc^scid/Prkdc^scid
NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz

Genotype: Il2rg^tm1Wjl/Y Prkdc^scid/Prkdc^scid
NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz

Additional - Il2rg^tm1Wjl related

Additional - Prkdc^scid related