David E. Bergstrom, Ph.D.
Research Scientist
Researches inner ear development and the genetics underlying vestibular function dysfunction, as well as dwarfism and skeletal malformation.
My research group studies mouse models with vestibular (inner ear) defects that may provide insights into balance disorders in humans. I am focusing on mutations that affect the structure and function of the otolithic end organs, small inner-ear structures that act as linear acceleration and gravity receptors. We have identified and characterized genes that are defective in head-tilt (het), head-slant (hslt), and neuromutagenesis facility (nmf) 333 mutant mice, each of which encodes an NADPH oxidase component. Thus, we've hypothesized that a previously unknown inner ear NADPH oxidase complex is necessary for proper development and function of the vestibular system.
I am also studying a mouse model that exhibits sex reversal, craniofacial defects and shortening of the limbs characteristic of some forms of human dwarfism. We have narrowed the genetic defect to a region on mouse Chromosome 7 and are analyzing that region of the genome with the goal of better understanding dwarfism and certain skeletal malformation syndromes in humans.
Education and experience
Education
The Jackson Laboratory
Postdoctoral Fellow
Adv: Dr. Eva M. Eicher
1996-1999
The Jackson Laboratory
Postdoctoral Trainee
Adv: Dr. Elizabeth M. Simpson
1994-1995
University of Illinois at Urbana-Champaign
Ph.D., biology (molecular genetics)
1994
University of Illinois at Urbana-Champaign
M.S., biology
1990
Illinois State University
B.S., biological sciences
1985
Experience
The Jackson Laboratory
Research scientist/Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science
2006-present
The Jackson Laboratory
Research scientist
2004-2005
The Jackson Laboratory
Associate research scientist/research scientist
1999-2004
Grants, Honors, and Accomplishments
NASA Certificate of Appreciation
Space Shuttle Endeavor STS-108
2001
School of Life Sciences Fellowship
University of Illinois
1986
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Tech CornerJuly 23, 2018Developing better gene editing technology
New CRISPR technology will be used to more quickly develop mouse models for gastric cancer, Down syndrome and other applications.
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Blog PostMarch 01, 2016Collectively, rare diseases are not so rare
A team from The Jackson Laboratory attended a Rare Disease Day 2016 event in Maine to help educate state legislators and staff about the challenges of living with rare diseases, and how JAX is empowering the scientific and medical communities to combat these diseases.