James Godwin has received a a five-year, $2.4M R01 grant to investigate regeneration in model organisms, and his work with mice so far has shown that multiple immune-cell types inhibit tissue regeneration.
Maintaining experimental mouse colonies is a lot like juggling. There are a lot of balls that you have to keep in the air all the time. You need to evaluate the breeding performance, adjust the colony size to match required production, genotype the mice, and then plan and execute your experiments. It is easy to have concerns about genetic drift far down on your list of priorities. However, for mutant or transgenic mouse strains on inbred backgrounds dealing with potential genetic drift needs to be a priority.
A conversation with Professor and Scientific Director, JAX Mammalian Genetics Nadia Rosenthal, Ph.D., F.Med.Sci., who has stepped aside as editor-in-chief of npj Regenerative Medicine, a journal she launched five years ago.