Development and application of approaches for human and mouse microbiome analysis and genomic analysis of the evolution of Gram-negative pathogens.
Dr. Adams comes from a rich background including industry, government, academic, and nonprofit settings. Throughout, he has focused on applying leading edge genomic and bioinformatic approaches to a variety of research problems in biology.
As one of the founding scientists at TIGR, Dr. Adams contributed extensively to the first genome sequence of a free-living organism, Haemophilus influenzae, and other microbial genomes. A co-founder of Celera Genomics, he led the DNA sequencing and genome annotation groups. He directed the Drosophila, human, and mouse genome sequencing projects, and a large-scale re-sequencing program to identify novel SNPs in humans.
From 2003-2011, Dr. Adams was Associate Professor of Genetics at Case Western Reserve University where he developed a research program in the evolution and mechanisms of antibiotic resistance in the nosocomial pathogen Acinetobacter baumannii. He also served as Director of the Genomics Core facility.
From 2011-2016, Dr. Adams was the Scientific Director and Professor at the J. Craig Venter Institute. There he directed programs that characterized genomic changes in the evolution of antibiotic resistance in hospital-acquired infections.
Dr. Adams received a B.A. in Chemistry from Warren Wilson College in Swannanoa, NC and a Ph.D. in Biological Chemistry from the University of Michigan.
Wright, M.S., Suzuki, Y., Jones, M.B., Marshall, S.H., Rudin, S.D., van Duin, D., Kaye, K., Jacobs, M., Bonomo, R.A., and Adams, M.D. (2015) Genomic and transcriptomic analysis of colistin resistant clinical isolates of Klebsiella pneumoniae reveals multiple pathways of resistance. Antimicrob. Agents Chemoth. 59:536-43. Epub 11/10/14.
Weber, B.S., Hennon, S.W., Wright, M.S., de Barardinis, V., Adams, M.D., and Feldman, M.F. (2016) Genetic dissection of the type VI secretion system in Acinetobacter and identification of a novel peptidoglycan hydrolase TagX required for its biogenesis. mBio, 7(5). pii: e01253-16.
Wright, M.S., Haft, D.H., Harkins, D.M., Perez, F., Hujer, K.M., Bajaksouzian, S., Benard, M.F., Jacobs, M.R., Bonomo, R.A., and Adams, M.D. (2014) New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis. mBio, 5(1) pii: e00963-13.
Wright, M.S., Perez, F., Brinkac, L., Jacobs, M.R., Kaye, K.S., Cober, E., van Duin, D., Marshall, S.H., Hujer, A.M., Rodin, S.D., Hujer, K., Bonomo, R.A., and Adams, M.D. (2014) Population Structure of KPC-producing Klebsiella pneumoniae from Midwestern US hospitals. Antimicrob Agents Chemoth., 58(8): 4961-4965.
Adams, M.D., Bishop, B., and Wright, M.W. (2016) Quantitative assessment of insertion sequence impact on bacterial genome architecture, Microbial Genomics, doi: 10.1099/mgen.0.000062 published online 4/18/16
The Connecticut Microbiome Initiative seeks to promote investment and collaboration to facilitate development of microbiome-related...
In this intensive 2 1/2 day workshop, participants will be introduced to theory, experimental design, analysis and interpretation of...