Candice N. Baker, Ph.D

As an Associate Research Scientist & Program Manager for The Cube Initiative at the Jackson Laboratory, I oversee the wetlab portion of large-scale mouse projects. I am interested in the mechanisms of metabolic and cardiovascular diseases and how to use the mouse to model these diseases. The Cube Initiative is an ambitious project in a proof of concept phase currently studying Type 2 Diabetes. Here we are performing ATAC seq, RNA seq, Isoform seq, single cell RNA seq, single nucleus ATAC seq, metabolomics, proteomics, as well as in-depth metabolic phenotyping in mouse models predicted to display varied phenotypic manifestations of T2D.

I also have deep knowledge of CRISPR/Cas9 gene manipulations and mouse model generation. With my experience in Genetic Engineering Technologies, I worked with collaborators to design new mouse models. I have carried this knowledge into my personal research where I am creating new models for T2D as well as cardiovascular diseases. The new models will be used to test genetic drivers of disease predicted from multiple human data sets.

Download cv