Our breeding and integrated services save you time, space, and money. JAX simplifies your mouse colony management by shipping mice to you as needed.
To create large, complex, targeted mutations, more traditional techniques are still needed. For those applications, our expert ES cell blastocyst injection service can take you successfully from a modified ES clone to a chimeric mouse in a matter of weeks.
In order to meet the need for blastocyst injections of modified ES cells, we offer microinjection services of your ES cell clone into one of three different host blastocysts. Following microinjection, embryos are transferred to host females to produce chimeric founder mice which are expected to carry the new genetic modification.
Once clones arrive, we will karyotype them to verify chromosome number as part of our full service offering. Once this is complete the mES cells will be microinjected into host blastocysts and transferred into pseudopregnant females. Chimeric pups will be identified by coat color and delivered at 6 weeks of age.