As an early adopter of the CRISPR/CAS9 technology, The Jackson Laboratory has been exploring the capabilities and limitations of the technology for generating mouse models. We guide you from concept to phenotypic characterization, allowing you and your staff to focus on the research instead of breeding mice.
We have the experience to deliver a range of mutational approaches on diverse strain backgrounds to make the model you need for your research.
When you partner with us to build your model, we keep it simple for you so you can stay focused on your research. The process includes 5 easy steps. We will:
|Model Type||Timeline (Weeks)|
| Small KI
Stop codon insertion
| Large KI (including ROSA26 locus)
LoxP site insertion
You can save time and effort when you opt for additional services to support your specific project goals.
To learn more about our CRISPR/Cas9 Mouse Model Generation Services or to set up a project, please call 1-800-422-6423 or email email@example.com.
JAX MGS utilized a short oligo-mediated knockin approach to generate a small mouse model panel in which each model carries a mouse allele that has been modified to carry a different, specified amino acid at key orthologous positions identified in the FALS patient analysis.
CRISPR/Cas9 techniques are quickly growing in popularity for the generation of new mouse models for research. Though the approach is relatively simple, many researchers struggle with understanding the complexities associated with the diverse alleles that can be generated, how to deal with mosaicism, and how to move from a single founder mouse to larger cohorts for phenotype characterization.
To support a collaboration between Dr. Cat Lutz of The Jackson Laboratory and the Friedrich’s Ataxia Research Alliance, our Model Generation Services (MGS) team undertook a project to create a conditional knockout allele of the Frataxin (Fxn) gene using the Cre-loxP Recombination System.
Do you need to generate new mouse models within 3-4 months instead of 1-1.5 years? Revolutionary CRISPR/Cas technology enables rapid, economical model generation through precise genome editing. During this webinar, we will help you understand the potential of CRISPR/Cas to accelerate your research.