This workshop is focused on the improvement of preclinical translation in Alzheimer’s Disease research. It will leverage the expertise and facilities of the University of Pittsburgh, Indiana University and JAX Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL-AD) Precision Medicine consortium.
The in-person course includes lectures, hands-on workshops, and featured evening lectures and discussion sessions. Through this workshop, you will experience a significant amount of hands-on, practical laboratory training in in vivo drug screening. We also strive to support you in your research project and career advancement through networking with experts and peers to promote collaborative research.
The virtual audience will have access to the live-stream for lectures and will have the ability to ask questions at the end of each lecture through a virtual Q+A function. In addition, all lectures will be recorded and posted within 72 hours of airing on a centralized Canvas course that participants will have access to for six months following the course.
The virtual audience will not have access to live or recorded versions of workshops or special evening sessions. The sessions not accessible to the virtual audience are highlighted in blue on the schedule.
Please contact the event organizer for more information
May 08 - 12
2023
We invite you to join us for an immersion workshop focusing on the improvement of preclinical translation in Alzheimer’s Disease research. This workshop will leverage the expertise and facilities of the University of Pittsburgh, Indiana University and JAX Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL-AD) Precision Medicine consortium. We aim to address training gaps in preclinical drug screening by providing you with the skills and knowledge required for rigorous design, execution, analysis, and reporting of pharmacokinetic, pharmacodynamics, and preclinical efficacy experiments. Additionally, we will focus on the selection and appropriate use of mouse models in translational research.
Through this workshop, you will experience a significant amount of hands-on, practical laboratory training in in vivo drug screening. We also strive to support you in your research project and career advancement through networking with experts and peers to promote collaborative research.
View the 2023 Schedule to get a feel for course content, format, and flow. Please note that this schedule is still subject to change.
Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R13AG060708. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The Jackson Laboratory (JAX) Courses and Conferences program is committed to:
(1) Fostering an educational and working environment that encourages and supports our mission and the promotion of free and open exchange of scientific ideas;
(2) Creating and maintaining a safe and respectful environment for all in-person and virtual participants in educational programs, including event directors and organizers, internal and invited speakers, attendees, and all staff; and
(3) Providing an environment free from discrimination and harassment, in accordance with federal, state and local law, at all of our courses, conferences, symposia and workshops delivered both on and off of the JAX campuses.
The Code and expectations outlined below are aligned with the JAX Code of Conduct and NIH Policy and are applicable to all intramural and extramural participants including faculty, trainees, students and staff.
By registering for and attending a JAX Courses and Conferences -facilitated meeting or event, either in person or virtually, participants agree to:
By participating in JAX Courses and Conferences programming attendees, either in person or virtually, agree to refrain from:
What to do in case of breaches or violations of these guidelines:
Program organizers and leadership can be approached informally about any apparent or actual breaches or violations. Breaches or violations should be reported to the specific program leader or to JAX Courses and Conferences organizers in person or by email:
Reports can be submitted by those who experience harassment or discrimination as well as by those who witness violations of the behavior laid out in this Code. The TDCC will act as needed to resolve the matter, up to and including immediate expulsion of the offending participant(s) from the meeting and exclusion from future events offered by JAX. Individuals at any NIH-supported conference who have questions, concerns or complaints related to harassment or discrimination can also file a report with the HHS Office for Civil Rights (OCR) or notify NIH. Seeking assistance from a program leader or organizer in no way prohibits filing complaints with HHS OCR.
8:30 AM |
Monday, May 8th 8:30 Welcome and Course overview
9:00 NIA Translational Programs Lorenzo Refolo, Ph.D., NIH, National Institute on Aging
9:45 MODEL-AD Overview Mike Sasner, Ph.D., The Jackson Laboratory
10:15 MODEL-AD BDMC Greg Carter, Ph.D., The Jackson Laboratory
11:15 MODEL-AD DMP Gareth Howell, Ph.D., The Jackson Laboratory
1:00 MODEL-AD PTC Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine Paul Territo, Ph.D., Indiana School of Medicine
3:00 Breakout and brainstorm session: The right model for the right experiment Gareth Howell, Ph.D., The Jackson Laboratory
4:00 Drug Discovery Roadmap – from Idea to Drug Approval Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine 7:30 Town Hall Meeting, Topic: Research Integrity
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8:00 AM |
Tuesday, May 9th 8:00 Hands-on Laboratory Session: Biomethods Training (Required) Angela Begin, MLAS, LVT, RLATg, Benjamin Carter, Travis Burpee, The Jackson Laboratory Restraint, IP, SC and PO dosing (and specific related restraints), Serial tail bleeds, Cheek bleed (submandibular), Ear notching, Perfusion(without pump), Fresh catch fecals (for microbiome), p-chipping.
1:00 Mouse Models Resources, Nomenclature and Tools (cre, tet, KOMP, MGI) & AlzForum Resources
2:00 Multi-omics approaches in AD and as tools for therapeutic discovery Nick Seyfried, Ph.D., Emory University
3:30 Biomarkers, Enabling Drug Discovery, Clinical Development and Personalized Medicine Jeffrey L. Dage, Ph.D., Indiana University School of Medicine (virtual)
4:30 TREAT-AD Alan Palkowitz, Ph.D., Indiana University School of Medicine (virtual)
7:00 Mouse Explorer Demo, AD Knowledge Portal, R Demo/Practicum Abby Vander Linden, Ph.D., Sage Bionetworks
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8:30 AM |
Wednesday, May 10th
8:30 Group 1: Lab Practicum: ARRIVE Guidelines in Experimental Design Hands-on Laboratory Session:In Vivo Dosing and Serial Blood Collections (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
12:30 Group 2: Lab Practicum: ARRIVE Guidelines in Experimental Design Hands-on Laboratory Session:In Vivo Dosing and Serial Blood Collections (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
4:00 PK/PD Modeling Lecture and Practicum Sara Quinney, Ph.D., Indiana University Paul Territo, Ph.D., Indiana University
7:00 Town Hall Meeting |
9:00 AM |
Thursday, May 11th 9:00 Group 1: Hands-on Laboratory Session: Terminal Cerebrospinal Fluid and Brain Tissue Collection, Perfusion demo/practice (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
12:30 Group 2: Hands-on Laboratory Session: Terminal Cerebrospinal Fluid and Brain Tissue Collection, Perfusion demo/practice (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
3:30 Translational Pharmacology: In Vivo PET/MR Paul Territo, Ph.D., Indiana School of Medicine
7:00 AD Therapeutics Pascal Sanchez, Ph.D., Denali Therapeutics |
8:30 AM |
Friday, May 12th 8:30 Translational Approaches for Studying Human Behaviors in Animal Models: MODEL-AD & MARMO-AD Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine
9:30 Human Genetic Diversity
11:00 Genetic Diversity in Modeling AD Kristen Onos, Ph.D., The Jackson Laboratory
1:00 Preclinical Statistics (Interactive workshop session) Vivek Phillip, Ph.D., The Jackson Laboratory
2:00 Alzheimer’s Association Funding Programs
3:30 Alzheimer's Disease Preclinical Efficacy Database Shreaya Chakroborty, Ph.D., NIH, National Institute on Aging
4:30 NIA Resources and Opportunities Maria Carranza, Ph.D., Training Officer (virtual) Office of Strategic Extramural Programs (OSEP) National Institute on Aging |
Professor, The Bernard and Lusia Milch Endowed Chair
Scientific Program Manager
Director, Medical & Scientific Relations
Professor, Diana Davis Spencer Foundation Chair for Glaucoma Research
Research Scientist
Director, Alzheimer's Disease Drug Discovery Center
Program Officer
Director, Computational Sciences
Associate Professor of Obstetrics and Gynecology
Program Officer
Associate Professor, University of Pittsburgh School of Medicine; Director PITT Preclinical Phenotyping Core; Co-Head MODEL-AD Preclinical Testing Core
Senior Research Scientist
Director, Emory Integrated Proteomics Core;Associate Professor, Department of Biochemistry
Associate Professor of Radiology, HEAD MODEL-AD Preclinical Testing Core
On-Campus
Lodging accommodations at JAX’s Highseas Conference Center is available for an additional fee. Highseas, located approximately 1 mile from The Jackson Laboratory, is a spacious estate built in 1912, overlooking the entrance to Frenchman Bay and adjacent to beautiful Acadia National Park. Attendees are responsible for their own transportation to the Conference Center. We do provide shuttles to and from the main campus for the duration of the course. Highseas is handicap accessible (please indicate accessibility needs in registration). This lodging option cannot accommodate families. Rooms may be shared with other participants.
Off-Campus
Participants interested in securing off-campus lodging may refer to the Bar Harbor Chamber of Commerce website for a guide on hotels, motels, bed & breakfasts, and short-term rentals in the Bar Harbor area.
Meals will be provided by JAX’s campus dining services throughout the event. Participants staying off-campus may still partake in evening meals at Highseas. Please refer to the event schedule for more information.
Participants must adhere to Maine State travel, health and safety guidelines at the time of the event and use good judgement when arranging lodging. We recommend participants be familiar with their hotel’s cancellation policies prior to booking. The Jackson Laboratory is not responsible for lodging expenses or losses incurred due to the cancellation or rescheduling of an event.
Bar Harbor is served by two airports:
Bar Harbor is approximately 6 hours by car from the greater Boston area.
Rental cars are available from both BHB and BGR airports.
Associate Professor, University of Pittsburgh School of Medicine; Director PITT Preclinical Phenotyping Core; Co-Head MODEL-AD Preclinical Testing Core
Associate Professor of Radiology, HEAD MODEL-AD Preclinical Testing Core
Senior Research Scientist