We invite you to join us for an immersion workshop focusing on the improvement of preclinical translation in Alzheimer’s Disease research. This workshop will leverage the expertise and facilities of the Indiana University (IU)/JAX Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL-AD) Precision Medicine consortium.
Registration is Open
We invite you to join us for an immersion workshop focusing on the improvement of preclinical translation in Alzheimer’s Disease research. This workshop will leverage the expertise and facilities of the Indiana University (IU)/JAX Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL-AD) Precision Medicine consortium. We aim to address training gaps in preclinical drug screening by providing you with the skills and knowledge required for rigorous design, execution, analysis, and reporting of pharmacokinetic, pharmacodynamics, and preclinical efficacy experiments, particularly in the mouse. Through this workshop, you will experience a significant amount of hands-on, practical laboratory training in in vivo drug screening. We also strive to support you in your research project and career advancement through networking with experts and peers to promote collaborative research.
This course is for graduate students, postdocs, research scientists and junior faculty conducting or that will be conducting preclinical research in Alzheimer's Disease or related diseases. Scholarships are available for U.S. citizens.
This course is made possible by funding from the National Institute on Aging.
8:30 AM |
Monday, May 8th 8:30 Welcome and Course overview
9:00 NIA Translational Programs Lorenzo Refolo, Ph.D., NIH, National Institute on Aging
9:45 MODEL-AD Overview Mike Sasner, Ph.D., The Jackson Laboratory
10:15 MODEL-AD BDMC Greg Carter, Ph.D., The Jackson Laboratory
11:15 MODEL-AD DMP Gareth Howell, Ph.D., The Jackson Laboratory
1:00 MODEL-AD PTC Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine Paul Territo, Ph.D., Indiana School of Medicine
3:00 Breakout and brainstorm session: The right model for the right experiment Gareth Howell, Ph.D., The Jackson Laboratory
4:00 Drug Discovery Roadmap – from Idea to Drug Approval Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine
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8:30 AM |
Tuesday, May 9th 8:45 Hands-on Laboratory Session: Biomethods Training (Required) Staff, The Jackson Laboratory
1:00 Mouse Models Resources, Nomenclature and Tools (cre, tet, KOMP, MGI) & AlzForum Resources
2:00 Multi-omics approaches in AD and as tools for therapeutic discovery Nick Seyfried, Ph.D., Emory University
3:30 Biomarkers, Enabling Drug Discovery, Clinical Development and Personalized Medicine Jeffrey L. Dage, Ph.D., Indiana University School of Medicine (virtual)
4:30 TREAT-AD Alan Palkowitz, Ph.D., Indiana University School of Medicine (virtual)
7:00 Mouse Explorer Demo, AD Knowledge Portal, R Demo/Practicum Abby Vander Linden, Ph.D., Sage Bionetworks |
8:30 AM |
Wednesday, May 10th
8:30 Group 1: Lab Practicum: ARRIVE Guidelines in Experimental Design Hands-on Laboratory Session:In Vivo Dosing and Serial Blood Collections (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
12:30 Group 2: Lab Practicum: ARRIVE Guidelines in Experimental Design Hands-on Laboratory Session:In Vivo Dosing and Serial Blood Collections (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
4:00 PK/PD Modeling Lecture and Practicum Sara Quinney, Ph.D., Indiana University Paul Territo, Ph.D., Indiana University
7:00 Town Hall Meeting |
8:30 AM |
Thursday, May 11th 9:00 Group 1: Hands-on Laboratory Session: Terminal Cerebrospinal Fluid and Brain Tissue Collection, Perfusion demo/practice (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
12:30 Group 2: Hands-on Laboratory Session: Terminal Cerebrospinal Fluid and Brain Tissue Collection, Perfusion demo/practice (GRB Training Laboratory)
Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine and MODEL-AD PTC Staff
3:30 Translational Pharmacology: In Vivo PET/MR Paul Territo, Ph.D., Indiana School of Medicine
7:00 AD Therapeutics Pascal Sanchez, Ph.D., Denali Therapeutics |
8:30 AM |
Friday, May 12th 8:30 Translational Approaches for Studying Human Behaviors in Animal Models: MODEL-AD & MARMO-AD Stacey Rizzo, Ph.D., University of Pittsburgh School of Medicine
9:30 Human Genetic Diversity
11:00 Genetic Diversity in Modeling AD Kristen Onos, Ph.D., The Jackson Laboratory
1:00 Preclinical Statistics (Interactive workshop session) Vivek Phillip, Ph.D., The Jackson Laboratory
2:00 Alzheimer’s Association Funding Programs
3:30 Alzheimer's Disease Preclinical Efficacy Database Shreaya Chakroborty, Ph.D., NIH, National Institute on Aging
4:30 NIA Resources and Opportunities Maria Carranza, Ph.D., Training Officer (virtual) Office of Strategic Extramural Programs (OSEP) National Institute on Aging |
Professor, The Bernard and Lusia Milch Endowed Chair
Scientific Program Manager
Director, Medical & Scientific Relations
Professor, Diana Davis Spencer Foundation Chair for Glaucoma Research
Research Scientist
Director, Alzheimer's Disease Drug Discovery Center
Program Officer
Director, Computational Sciences
Associate Professor of Obstetrics and Gynecology
Program Officer
Associate Professor, University of Pittsburgh School of Medicine; Director PITT Preclinical Phenotyping Core; Co-Head MODEL-AD Preclinical Testing Core
Senior Research Scientist
Director, Emory Integrated Proteomics Core;Associate Professor, Department of Biochemistry
Associate Professor of Radiology, HEAD MODEL-AD Preclinical Testing Core
Registration Fee: $1350; Optional Shared Lodging Fee: $250
Standard Registration $150.00 Scholarship Registration $25.00
On-Campus
Lodging accommodations at JAX’s Highseas Conference Center is available for an additional fee. Highseas, located approximately 1 mile from The Jackson Laboratory, is a spacious estate built in 1912, overlooking the entrance to Frenchman Bay and adjacent to beautiful Acadia National Park. Attendees are responsible for their own transportation to the Conference Center. We do provide shuttles to and from the main campus for the duration of the course. Highseas is handicap accessible (please indicate accessibility needs in registration). This lodging option cannot accommodate families. Rooms may be shared with other participants.
Off-Campus
Participants interested in securing off-campus lodging may refer to the Bar Harbor Chamber of Commerce website for a guide on hotels, motels, bed & breakfasts, and short-term rentals in the Bar Harbor area.
Meals will be provided by JAX’s campus dining services throughout the event. Participants staying off-campus may still partake in evening meals at Highseas. Please refer to the event schedule for more information.
Participants must adhere to Maine State travel, health and safety guidelines at the time of the event and use good judgement when arranging lodging. We recommend participants be familiar with their hotel’s cancellation policies prior to booking. The Jackson Laboratory is not responsible for lodging expenses or losses incurred due to the cancellation or rescheduling of an event.
Bar Harbor is served by two airports:
Bar Harbor is approximately 6 hours by car from the greater Boston area.
Rental cars are available from both BHB and BGR airports.
Associate Professor, University of Pittsburgh School of Medicine; Director PITT Preclinical Phenotyping Core; Co-Head MODEL-AD Preclinical Testing Core
Associate Professor of Radiology, HEAD MODEL-AD Preclinical Testing Core
Senior Research Scientist