Colorectal cancer resources for healthcare providers
Colorectal cancer (CRC) is common, affecting approximately 140,000 individuals annually in the United States. The average person has a 5% lifetime risk to develop CRC. As with all cancers, CRC develops due to a combination of genetic, biologic, and environment factors interacting together. Approximately 5-10% cases of CRC are due to a hereditary syndrome, where a single gene alteration conveys a high risk of CRC and sometimes other cancers. The resources below provide opportunities to learn about hereditary colorectal cancer syndromes, how to use family history to assess risk level, genetic testing, using genetic information to inform management, and communicating with patients about genetic risk.
Lynch Syndrome Factsheet. Describes the clinical features, diagnosis, testing and genetics of Lynch syndrome (hereditary nonpolyposis colorectal cancer).
MUTYH-Associated Adenomatous Polyposis Factsheet. Describes the clinical features, diagnosis, testing and genetics of MUTYH-associated polyposis (MAP).
Genetically Related Cancers Tool. Lists the associated cancers and unique characteristics of common cancer susceptibility genes.
Targeted Colorectal and Polyp Family History Tool. Lists key questions and guidance for collecting a family history targeted toward colorectal cancer.
Cancer Risk Assessment Tool. Helps identify red flags and stratify cancer risk based on family history.
Colorectal Cancer Screening Guidelines Factsheet. Summarizes professional society guidance about screening for individuals at average, increased, and high risk of colorectal cancer.
Family History Collection Tips & Tools. Provides tips, resources, and tools for family history collection in clinical practice.
Pedigree Tool. A template to record a pedigree with standard pedigree nomenclature.
Hereditary Cancer Management Guidelines Factsheet. Lists and links to evidence-based guidelines and professional society publications that address management of hereditary and familial cancer.
Genetic Testing Methods eBook. Provides information about different genetic testing methods currently used in testing for hereditary cancer syndromes (enhanced e-book available for download).
Communicating Risk Factsheet. Outlines key points to consider when communicating risk to patients.
Pretest Counseling Key Points Factsheet. Outlines key points to address during pretest counseling.
Components of a Cancer Genetic Counseling Session Factsheet. Discusses the core components of a cancer genetic counseling session.
Cancer Genetic Services in Maine and Connecticut Tool. Lists available cancer genetic services in Maine and Connecticut.
GINA Discussion Guide. Provides talking points and key information about genetic discrimination and the Genetic Information Nondiscrimination Act (GINA), which protects individuals from the misuse of genetic information in health insurance and employment.
Free, self-directed programs for continuing education credit.
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
Join this webinar to learn about cutting edge preclinical mouse platforms used to evaluate immuno-modulatory therapies for...
The mammalian immune system has developed surveillance mechanisms that can detect cancerous cells; however successful tumor cells have...
The NOD scid gamma mouse uniquely supports the engraftment of human hematopoietic cells, enabling the creation of “humanized” NSG™...
A factsheet that provides tips to facilitate family communication about genetic risk and testing options.
Provides guidance in collecting a family history targeted toward colorectal cancer.
Free CME program for primary care providers about hereditary colorectal cancer syndromes
Key points to consider when communicating risk to patients.
Clinical features, diagnosis, testing and genetics of Lynch syndrome.
Questions that should be integrated into the targeted family history when there is a suggestion of a possible polyposis...
Factsheet about clinical aspects of familial adenomatous polyposis and attenuated FAP.
Key features and cancer risks associated with common hereditary cancer syndromes.
Research at Xiamen University suggests that Apc<sup>Min</sup> mice may be a useful tool for understanding the role of APC in tissues other...
This tool addresses key points in interpreting genetic testing and summarizes general clinical interpretations based on positive, negative,...
Over 300 patient-derived xenograft (PDX) tumors are available for engrafting into immunocompromised NSG™ mice for shipment to your facility...
Learn how mouse selection is critical for efficient propagation of primary human tumors and the maintenance of its microenvironment,...