Hereditary Cancer Management Guidelines

Management guidelines have been developed for several types of hereditary cancer susceptibility. However, guidelines do not exist for all hereditary cancers or all moderate-risk genes. For example, there are no widely accepted guidelines for pancreatic cancer screening. Guidelines do change regularly, so be sure to check for updates prior to using them for patient care.

The following organizations provide guidance for management for individuals at increased and high risk for cancer. Those that provide a guideline for a specific cancer type (breast, colorectal or prostate) are included in the charts below. These same groups, as well as others, may have published recommendations on when to consider genetic testing for hereditary cancer risk.

American Academy of Family Physicians, American Cancer Society, American College of Gastroenterology, American College of Obstetricians & Gynecologists, American College of Physicians, American Society of Clinical Oncology, National Comprehensive Cancer Network, US Multi Society Task Force (includes American College of Gastroenterology, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy), and US Preventive Services Task Force.

Management Guidelines Based on Genetic or Familial Risk


Breast Cancer

Organization

Genetic/Hereditary Risk

Increased/Familial Risk

American Cancer Society 

2007

2007

American College of Obstetricians & Gynecologists

2017

 

American Society of Clinical Oncology

2006

 

National Comprehensive Cancer Network*

Genetic/Familial High Risk Assessment Breast and Ovarian v.3.2019

Breast Cancer Screening and Diagnosis v.3.2018

* The National Comprehensive Cancer Network (NCCN) requires a free registration to access guidelines

Colon Cancer

Organization

Genetic/Hereditary Risk

Increased/Familial Risk

American Academy of Family Physicians

2018

2018

American College of Gastroenterology

2015

 

American College of Obstetricians & Gynecologists

2014

 

American College of Physicians

 

2012

American Society of Clinical Oncology

2015

 

National Comprehensive Cancer Network*

Genetic/Familial High Risk Assessment Colorectal v.1.2018

Colorectal Cancer Screening v.1.2018

US Multi Society Task Force

2014

2017

* The National Comprehensive Cancer Network (NCCN) requires a free registration to access guidelines

Prostate Cancer

Organization

Genetic/Hereditary Risk

Increased/Familial Risk

American Cancer Society

 

2010

American College of Physicians

 

2013

National Comprehensive Cancer Network*

Prostate Cancer Early Detection v.1.2019

Prostate Cancer Early Detection v.1.2019

US Preventive Services Task Force

 

2018

* The National Comprehensive Cancer Network (NCCN) requires a free registration to access guidelines

 

Updated May 2019