Manuals and Guides

  • Case Study: Creation of a Cre-dependent Fxn Knockout Allele for Friedreich’s Ataxia

    To support a collaboration between Dr. Cat Lutz of The Jackson Laboratory and the Friedrich’s Ataxia Research Alliance, our Model Generation Services (MGS) team undertook a project to create a conditional knockout allele of the Frataxin (Fxn) gene using the Cre-loxP Recombination System.

  • Guide: Aged C57BL/6J Mice for Research Studies

    Mice are used extensively in aging research due to their genetic and physiological similarity to humans. Aging studies are—by necessity—lengthy, resource intensive, and require advance planning. The Jackson Laboratory now offers study-ready cohorts of male and female C57BL/6J mice up to 78 weeks of age. This article is intended to support investigators who may be new users of this resource and more experienced researchers who may be seeking a quick and useful summary. We will review special considerations for maximizing the translational value of data collected from aged mice and highlight resources for identifying and implementing best practices.

  • Fact Sheet: CRISPR/Cas9 Mouse Model Generation Services

    JAX can help you design the model you need and produce it on the genetic background of your choice by leveraging our 85+ years of mouse experience and our 8,500 mouse models. The guide explains how we can help every step of the way, from concept to providing phenotypic characterization, allowing you and your staff to focus on the research instead of breeding mice.

  • Infographic: Humanized NSG™ Mouse Model Selection

    NOD scid gamma (NSG™), a highly immunodeficient mouse only available from The Jackson Laboratory, provides the unmatched ability to model normal and malignant tissues and cells notoriously difficult to engraft and study in other mouse strains. This infographic helps you to determine which model is best for your research.

  • Guide: Humanized NSG™ Mice for Infectious Disease Research

    Humanized NSG™ mice are used by researchers and drug discovery scientists as powerful tools to study hematopoiesis, inflammatory disease and viral host-pathogen interactions. These mouse models are accelerating the development of novel therapies in HIV infection and oncology. This guide describes the development of humanized mice and how to select the appropriate model for your research

  • Handbook: Genetically Standardized Mice

    The definitive resource for anyone working with laboratory mice, this is the 6th edition of The Jackson Laboratory Handbook on Genetically Standardized Mice.

  • Guide: Mouse Models of Spinal Muscular Atrophy

    This guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development.

  • Guide: Working with Mouse Models of Huntington's Disease

    Working jointly with CHDI and PsychoGenics, Inc., we created a valuable guide packed with best practices for managing Huntington’s disease mouse colonies and preclinical research study design considerations.

  • Booklet: Colony Management

    JAX is the global leader in mouse genetics and husbandry, and has been a driving force in developing and supporting innovative approaches to mouse breeding and reproduction. This booklet explains how our comprehensive colony management solutions are designed to partner with your basic science or commercial drug discovery program to meet your research objectives.

  • Booklet: Neurological Mouse Models

    This booklet contains a comprehensive suite of solutions to support your research using neurological mouse models.

  • Booklet: Quality Management

    This booklet explains that through our industry-leading animal health and genetic stability programs, our team of scientists and mouse husbandry professionals ensures that mouse strains you receive are uniform, well-characterized, and have the highest health quality available.

  • Portfolio: Parkinson's Research Resources

    This portfolio demonstrates how our Parkinson’s disease (PD) mouse models are essential to advancing our understanding of disease pathophysiology and testing of potential therapeutics.

  • Portfolio: PDX Live™ - Efficacy Studies On Demand

    This portfolio explains our optimized Patient Derived Xenograft (PDX) efficacy studies utilizing its PDX Live™ library. These select tumors are kept at low passage in live donor mice, enabling fast-tracked efficacy testing studies for pre-clinical cancer drug development, potentially saving months of pre-study time.

  • Portfolio: Optogenetic Research Resources

    This portfolio describes how the fields of optogenetics, transient-sensing (calcium-, voltage-, glutamate-) technologies, and chemogenetics have accelerated over the past 5-10 years - as the tools and techniques have been reduced to practice and applied to fields including behavior, memory, mental illness, and disease.

  • Fact Sheet: Cancer Treatment Profile™

    The JAX Cancer Treatment Profile™ is a targeted panel of 358 cancer related genes and 53 genes known to form fusions associated with various carcinomas, sarcomas and hematologic malignancies; analyzed using next-generation sequencing.

  • PDX-Seq

    Cutting edge sequencing for preclinical oncology.