Manuals and Guides

  • Guide: Generating Mouse Models with CRISPR/Cas9

    Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.

  • Infographic: Humanized NSG™ Mouse Model Selection

    NOD scid gamma (NSG™), a highly immunodeficient mouse only available from The Jackson Laboratory, provides the unmatched ability to model normal and malignant tissues and cells notoriously difficult to engraft and study in other mouse strains. This infographic helps you to determine which model is best for your research.

  • Guide: Humanized NSG™ Mice for Infectious Disease Research

    Humanized NSG™ mice are used by researchers and drug discovery scientists as powerful tools to study hematopoiesis, inflammatory disease and viral host-pathogen interactions. These mouse models are accelerating the development of novel therapies in HIV infection and oncology. This guide describes the development of humanized mice and how to select the appropriate model for your research

  • Handbook: Genetically Standardized Mice

    The definitive resource for anyone working with laboratory mice, this is the 6th edition of The Jackson Laboratory Handbook on Genetically Standardized Mice.

  • Guide: Mouse Models of Spinal Muscular Atrophy

    This guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development.

  • Field Guide: Working with Mouse Models of Huntington's Disease

    Working jointly with CHDI and PsychoGenics, Inc., we created a valuable resource packed with best practices for managing Huntington’s disease mouse colonies and preclinical research study design considerations.

  • Booklet: Colony Management

    JAX is the global leader in mouse genetics and husbandry, and has been a driving force in developing and supporting innovative approaches to mouse breeding and reproduction. This booklet explains how our comprehensive colony management solutions are designed to partner with your basic science or commercial drug discovery program to meet your research objectives.

  • Booklet: Neurological Mouse Models

    This booklet contains a comprehensive suite of solutions to support your research using neurological mouse models.

  • Booklet: Quality Management

    This booklet explains that through our industry-leading animal health and genetic stability programs, our team of scientists and mouse husbandry professionals ensures that mouse strains you receive are uniform, well-characterized, and have the highest health quality available.

  • Portfolio: Parkinson's Research Resources

    This portfolio demonstrates how our Parkinson’s disease (PD) mouse models are essential to advancing our understanding of disease pathophysiology and testing of potential therapeutics.

  • Portfolio: PDX Live™ - Efficacy Studies On Demand

    This portfolio explains our optimized Patient Derived Xenograft (PDX) efficacy studies utilizing its PDX Live™ library. These select tumors are kept at low passage in live donor mice, enabling fast-tracked efficacy testing studies for pre-clinical cancer drug development, potentially saving months of pre-study time.

  • Fact Sheet: ActionSeq™

    The JAX ActionSeq™ test is a targeted panel of 212 cancer related genes analyzed using next-generation sequencing. The panel assesses all identified functional variants for clinical relevance, based on associations in the biomedical literature with response or resistance to FDA-approved targeted therapies.

  • Fact Sheet: FusionSeq™

    Every patient is unique. So is every patient’s tumor. This one pager explains how advances in high-throughput molecular diagnostics now allow detection of the genetic alterations that are specific to an individual patient’s tumor. By identifying the oncogenic drivers, therapeutic options can be matched to the tumor’s biology.