JAX offers 3 types of humanized NSG™ (hu-NSG™) mice engrafted with primary cells that generate functional human immune systems with different capabilities.
Humanized NSG™ mice are used by researchers and drug discovery scientists as powerful tools to study hematopoiesis, inflammatory disease and viral host-pathogen interactions. These mouse models are accelerating the development of novel therapies in HIV infection and oncology.
Mouse In Vitro Fertilization (IVF) can be used to rapidly expand mouse lines from a few males that carry the desired genotype or to maintain strains with poor breeding efficiency. This guide describes a detailed method using acidified Tyrode solution to open the zona pellucida, and increase the fertilization capacity of frozen mouse sperm.
Guidelines for preclinical testing and colony management of ALS mice discusses considerations for preclinical studies using SOD1 mice, colony management, QPCR protocol for determining copy number, and more.
Download a listing of MHC H2 Haplotypes and Histocompatibility Haplotypes and Loci for JAX® Mice.
NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
The definitive resource for anyone working with laboratory mice, the 6th edition of The Jackson Laboratory Handbook on Genetically Standardized Mice.
This reference guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development.
Working jointly with CHDI and PsychoGenics, Inc., we created a valuable resource packed with best practices for managing Huntington’s disease mouse colonies and preclinical research study design considerations.