Cancer
In this series, we discuss mouse models and techniques used to answer basic and preclinical research questions about cancer initiation, progression, and therapeutic interventions.
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Introduction to Mice for Cancer Immunotherapy ResearchNovember 14, 2019, 1:00 PM USA Eastern Time Would you like to learn about using mouse models to develop novel cancer immunotherapies? During this webinar, we will provide an overview of mouse models and new humanized mouse platforms being used to improve the translational relevance of cancer immunotherapy research. |
Improving Translational Relevance of Preclinical Mouse Models for Alzheimer's DiseaseNovember 21, 2019, 1:00 PM USA Eastern Time Alzheimer’s Disease (AD) is a complex genetic disorder, which further complicates developing and validating mouse models for preclinical research. In this presentation, we will review the limitations of traditional mouse models used in AD research that have not translated well in the clinic. We also will discuss the rationale for generating new models that more accurately represent the genetically diverse population of patients with AD, as well as best practices for efficacy testing of therapeutic candidates. |
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International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
New preclinical data reported in the journal Science Translational Medicine (Burak et al., 2015) demonstrates that a monoclonal antibody to...
It’s the New Year. Did you resolve to lose weight (again)? Using optogenetic approaches and behavioral assays in mice, neuroscientists at...
“Optopatch” mice allow both optogenetic stimulation and simultaneous optical recording of electrical outputs in the same neuron. They are...
Learn about a method that combines optogenetic and multi-electrode systems to provide spatiotemporal modulation of and simultaneous...
Learn about the effects of feeding a high fat diet to NON/ShiLtJ males, a new mouse model for diet-induced obesity (DIO) and...
Learn about the pros and cons of using Apoe or Ldlr knockout mice for atherosclerosis research.
Learn how mice lacking OPN are protected against the development of diet-induced obesity (DIO) and hepatic steatosis.
Neuroscience is still a young science. Optogenetics provides an intriguing way to explore what’s going on inside our brains.
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
Learn how seven immunodeficient mouse models helped figure out which cell types mediate the autoimmune destruction of insulin-producing...
Multi-omic profiling of pediatric brain and bone cancer to discover novel prognostic biomarkers and therapeutic targets.
The USPSTF updated this important screening recommendation in August, 2019. It now recommends screening for potentially harmful BRCA1 and...
Aiming to understand the aging process from a microbiome prospective, looking for interventions on aging related chronic low-grade...