Cancer
In this series, we discuss mouse models and techniques used to answer basic and preclinical research questions about cancer initiation, progression, and therapeutic interventions.
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Rapid in Vivo Evaluation of Immunomodulatory Therapies Using Hu-PBMC NSG™ MiceAugust 1, 2019, 1:00 PM USA Eastern Time Do you need a translationally-relevant preclinical platform to rapidly assess or develop human T cell immunomodulatory therapies? Engrafting NSG™ mice with human peripheral blood mononuclear cells (Hu-PBMC) leads to xenogeneic activation and proliferation of human T cells within these models. The resulting Hu-PBMC NSG models then can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft versus host disease (GvHD), autoimmune disorders, and cancer. |
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International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
New preclinical data reported in the journal Science Translational Medicine (Burak et al., 2015) demonstrates that a monoclonal antibody to...
It’s the New Year. Did you resolve to lose weight (again)? Using optogenetic approaches and behavioral assays in mice, neuroscientists at...
“Optopatch” mice allow both optogenetic stimulation and simultaneous optical recording of electrical outputs in the same neuron. They are...
Learn about a method that combines optogenetic and multi-electrode systems to provide spatiotemporal modulation of and simultaneous...
Learn about the effects of feeding a high fat diet to NON/ShiLtJ males, a new mouse model for diet-induced obesity (DIO) and...
Learn about the pros and cons of using Apoe or Ldlr knockout mice for atherosclerosis research.
Learn how mice lacking OPN are protected against the development of diet-induced obesity (DIO) and hepatic steatosis.
Neuroscience is still a young science. Optogenetics provides an intriguing way to explore what’s going on inside our brains.
My research interests are the single molecule long-read sequencing technologies, genomic structural variations and their contribution to...
Learn how seven immunodeficient mouse models helped figure out which cell types mediate the autoimmune destruction of insulin-producing...
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
Aiming to understand the aging process from a microbiome prospective, looking for interventions on aging related chronic low-grade...
This JAX course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of...
Enabling the development of novel therapies for serious illnesses.