Cancer
In this series, we discuss mouse models and techniques used to answer basic and preclinical research questions about cancer initiation, progression, and therapeutic interventions.
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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn MiceSeptember 19, 2019, 4:00 PM Central European Time Do you need reliable pharmacokinetic (PK) data to evaluate human immunoglobulin or albumin-based therapeutic drug candidates? The humanized FcRn (Hu-FcRn) mouse model enables you to obtain clinically-relevant PK data related to drug half-life. This critically important PK data helps optimize the design of preclinical efficacy studies and to de-risk lead selection. |
Predictive Cancer Models Using Patient-derived Xenograft MiceSeptember 26, 2019, 1:00 PM USA Eastern Time Do you need pre-clinical models that represent the diversity of cancer patient demographics? Using patient-derived xenograft (PDX) mice enables modeling the heterogeneity of human cancer and conducting more translationally-relevant cancer research studies. |
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Engineering the human skin microbiome to treat diseases and prevent infections.
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
New preclinical data reported in the journal Science Translational Medicine (Burak et al., 2015) demonstrates that a monoclonal antibody to...
It’s the New Year. Did you resolve to lose weight (again)? Using optogenetic approaches and behavioral assays in mice, neuroscientists at...
“Optopatch” mice allow both optogenetic stimulation and simultaneous optical recording of electrical outputs in the same neuron. They are...
Extrachromosomal DNA in brain tumor development
Online analysis tool, Protein-RNA Association Strength (PRAS), free for academic researchers.
Learn about the effects of feeding a high fat diet to NON/ShiLtJ males, a new mouse model for diet-induced obesity (DIO) and...
Learn about the pros and cons of using Apoe or Ldlr knockout mice for atherosclerosis research.
Learn about a method that combines optogenetic and multi-electrode systems to provide spatiotemporal modulation of and simultaneous...
Investigates the key genomic change in cancers and reproduce and demonstrate the effect in vitro/vivo
I am interested in applying machine learning and advanced statistical modelling into biological questions.
Learn how mice lacking OPN are protected against the development of diet-induced obesity (DIO) and hepatic steatosis.
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
This course includes daily lectures in the mornings and evenings as well as afternoon mini-symposia, workshops, tutorials, demonstrations...
Neuroscience is still a young science. Optogenetics provides an intriguing way to explore what’s going on inside our brains.