My primary research focuses on how encounters with antigens, whether through vaccination or infection, significantly influence the differentiation, maturation, receptor repertoire-diversification, and immunological memory of human NK cells. This intricate process results in the development of distinct functional subsets of NK cells, ultimately impacting the host's protection against viral diseases.
Understanding how NK cells specifically respond to distinct viral infections remains a focal point, holding significance for pioneering new treatment modalities. In particular, identifying the pivotal signaling pathways governing the activation and migration of NK cells in response to specific infections stands as an imperative pathway for future research. This understanding is critical in laying the groundwork for future NK cell-based therapies.
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