The Jackson Laboratory

2026 Computational Sciences Publications

2026 Publications:

  1. Ouardouz M, Hernan AE, Mahoney JM, Scott RC. Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in Fmr1 KO mice. iScience. 2026;29(3):115066. PMID: 41809053; PMCID: PMC12969123. https://libkey.io/libraries/3075/41809053

  2. Durante GL, Tyler AL, Scott RC, Hernan AE, Mahoney JM. Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape. Epilepsia. 2026;67(3):1421-32. PMID: 41358547; PMCID: PMC13007847. https://libkey.io/libraries/3075/41358547

  3. Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR, 3rd, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM, The Emory-Sage-SGC-JAX TREAT-AD Center. PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice. Alzheimers Dement. 2025;21(12):e71033. PMID: 41451871; PMCID: PMC12741935. https://libkey.io/libraries/3075/41451871

  4. Sabnis GS, Hession L, Mahoney JM, Mobley A, Santos M, Geuther B, Kumar V. Visual detection of seizures in mice using supervised machine learning. Cell Rep Methods. 2025;5(12):101242. PMID: 41308647. https://libkey.io/libraries/3075/41308647

  5. Ordaz T, Sundaramurthi JC, Arterbery AS, Bagley AM, Gargano MA, Bauer JP, Danis D, Giampietro P, Raney E, Rekerle L, Shingle M, Davids JR, Robinson PN. An ITPR1 Variant in the IP3-ITPR1 Binding Pocket Associated With a Clinical Phenotype of Athetoid Cerebral Palsy. Am J Med Genet A. 2026;200(2):459-67. PMID: 40968496. https://libkey.io/libraries/3075/40968496

  6. Cary GA, Li Q, Wiley JC, Paisie CA, Du Y, Zoeller EL, Duong D, Fu H, Seyfried NT, Levey AI, Betarbet R, Carter GW, for The Emory-Sage-SGC-JAX TREAT-AD Center. Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets. Alzheimers Dement. 2025;21(12):e71008. PMID: 41388808; PMCID: PMC12701361. https://libkey.io/libraries/3075/41388808

  7. Arnuk A, Han C, Lawal AE, Wang B, Karma S, Zhang Z, Yassouf MY, Rajendran SH, Chandok H, Eller ML, Sajedi S, McKenna M, Herman E, Hagen L, Nadorp B, Mo Z, Orellana H, Tsirigos A, Miura P, Abbas HA, Aifantis I, Wang E. Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia. Sci Transl Med. 2026;18(838):eady2936. PMID: 41739902. https://libkey.io/libraries/3075/41739902

  8. Lindsay H, Du Y, Qi L, Zhang H, Zhao S, Braun FK, Kogiso M, Stephan C, Alton G, Stein G, Beaton G, Kesari S, Neuhauser S, Stearns T, Chuang J, Jocoy EL, Bult CJ, Teicher B, Smith MA, Li XN. Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models. Int J Mol Sci. 2026;27(3). PMID: 41683962; PMCID: PMC12898090. https://libkey.io/libraries/3075/41683962

  9. Abdelfattah N, Natarajan S, Tran HN, Wong T, Faisal M, Maldonado J, McMinimy R, Borland H, Chen SH, Zhao H, Vasquez M, Rodriguez FF, Wagner CR, Camargo F, Olson J, George J, Yun K. Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma. Cancer Cell. 2026;44(4):760-76 e8. PMID: 41650973; PMCID: PMC12885226. https://libkey.io/libraries/3075/41650973

  10. Hardy CC, Sheehan S, Mawe S, Sebasco N, Ricke W, Mahoney M, Korstanje R. Spoti-find: a novel, open-source void spot assay image analysis tool. Am J Physiol Renal Physiol. 2026;330(5):F513-F21. PMID: 41874957. https://libkey.io/libraries/3075/41874957

  11. Kaur S, Tyler AL, Durante GL, Cary GA, Carter GW, Mahoney JM. Identifying transcriptomic signatures that mediate the causal effect of genotype on Alzheimer's disease. Front Neurosci. 2026;20:1716828. PMID: 41938695; PMCID: PMC13044590. https://libkey.io/libraries/3075/41938695

  12. Ouardouz M, Hernan AE, Mahoney JM, Scott RC. Auditory Stimulation Rescues Cognitive Deficit in Fmr1-KO Mice. Brain Sci. 2026;16(4):380. PMID: 42041789; PMCID: PMC13114061. https://libkey.io/libraries/3075/42041789

  13. Reese JT, Chimirri L, Bridges Y, Danis D, Caufield JH, Gargano MA, Kroll C, Schmeder A, Liu F, Wissink K, McMurry JA, Graefe ASL, Niyonkuru E, Korn DR, Casiraghi E, Valentini G, Jacobsen JOB, Haendel M, Smedley D, Mungall CJ, Robinson PN. Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools. Eur J Hum Genet. 2026;34(4):498-504. PMID: 41735669; PMCID: PMC13046788. https://libkey.io/libraries/3075/41735669

©2026 The Jackson Laboratory