Aging Center Publications

Recent publication highlights


  • Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223. PMCID:PMC4707687 [full text] [ Epub 2014 Dec 22]
  • Bogue MA, Churchill GA, Chesler EJ Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database Mamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6 PMCID: PMC4602074 [full text] [ Epub 2015 Aug 19 ]
  • Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans Aging Cell. 2016 Jun 30. doi: 10.1111/acel.12499 [ Pubmed ] [Epub ahead of print]


  • Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL Aging Research Using Mouse Models Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195 PMCID: PMC4590775 [full text]
  • Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo Oncotarget. 2015 Nov 24;6(37):39714-24. doi: 10.18632/oncotarget.5356 PMCID: PMC4741857 [ Full text ]
  • Noordmans GA, Hillebrands JL, van Goor H, Korstanje R A roadmap for the genetic analysis of renal aging Aging Cell. 2015 Oct;14(5):725-33. doi: 10.1111/acel.12378 PMCID: PMC4568960 [full text] [ Epub 2015 Jul 29]
  • Reznichenko A, Korstanje R The role of platelet-activating factor in mesangial pathophysiology Am J Pathol. 2015 Apr;185(4):888-96. doi: 10.1016/j.ajpath.2014.11.025 PMCID: PMC4380849 [full text] [ Epub 2015 Feb 2]
  • Yuan R, Gatti DM, Krier R, Malay E, Schultz D, Peters LL, Churchill GA, Harrison DE, Paigen B Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1 J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):817-26. doi: 10.1093/gerona/glu114 PMCID: PMC4481683 [full text] [ Epub 2014 Jul 28]


  • Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA Quantitative trait locus mapping methods for diversity outbred mice G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748 PMCID: PMC4169154 [full text]
  • Gokhin DS, Dubuc EA, Lian KQ, Peters LL, Fowler VM Alterations in thin filament length during postnatal skeletal muscle development and aging in mice Front Physiol. 2014 Sep 29;5:375. doi: 10.3389/fphys.2014.00375 PMCID: PMC4178374 [full text]

    [ eCollection 2014]

  • Grubb SC, Bult CJ, Bogue MA Mouse phenome database Nucleic Acids Res. 2014 Jan;42(Database issue):D825-34. doi: 10.1093/nar/gkt1159 PMCID: PMC3965087 [full text] [ Epub 2013 Nov 15]
  • Huang Y, Caputo CR, Noordmans GA, Yazdani S, Monteiro LH, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands JL Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice PLoS One. 2014 Mar 17;9(3):e91850. doi: 10.1371/journal.pone.0091850 PMCID: PMC3956762 [full text]

    [ eCollection 2014]

  • Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching Aging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226 PMCID: PMC4326954 [full text] [ Epub 2014 May 23]
  • Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C; Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains Immunological Genome Consortium. J Immunol. 2014 Nov 1;193(9):4485-96. doi: 10.4049/jimmunol.1401280 PMCID: PMC4201955 [full text]

    [ Epub 2014 Sep 29]

  • Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308 PMCID: PMC4213026 [full text]
  • Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1296-307. doi: 10.1152/ajprenal.00074.2014 PMCID: PMC4042106 [full text] [ Epub 2014 Apr 9]


  • Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ High-precision genetic mapping of behavioral traits in the diversity outbred mouse population Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029 PMCID: PMC3709837 [full text] [ Epub 2013 Mar 20]
  • Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H, Korstanje R Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene J Am Soc Nephrol. 2013 Dec;24(12):1995-2001. doi: 10.1681/ASN.2012080838 PMCID: PMC3839541 [full text] [ Epub 2013 Sep 5]
  • Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070 PMCID: PMC3598361 [full text] [ Epub 2012 Mar 26]
  • Yuan R, Flurkey K, Meng Q, Astle MC, Harrison DE Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):27-35. doi: 10.1093/gerona/gls104 PMCID: PMC3598364 [full text] [ Epub 2012 May 8]


  • Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Bult CJ, Eppig JT, Sundberg JP The Mouse Tumor Biology Database (MTB): a central electronic resource for locating and integrating mouse tumor pathology data Vet Pathol. 2012 Jan;49(1):218-23. doi: 10.1177/0300985810395726 PMCID: PMC3130112 [full text] [ Epub 2011 Jan 31]
  • Flurkey K, Yuan R How the evolutionary theory of aging can guide us in the search for aging genes Aging (Albany NY). 2012 May;4(5):318-9 PMCID: PMC3384432 [full text]

    [ No abstract available]

  • Kavirayani AM, Sundberg JP, Foreman O Primary neoplasms of bones in mice: retrospective study and review of literature Vet Pathol. 2012 Jan;49(1):182-205. doi: 10.1177/0300985811398252 PMCID: PMC3151475 [full text] [ Epub 2011 Feb 22]
  • Li Q, Berndt A, Guo H, Sundberg JP, Uitto J A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouse Am J Pathol. 2012 Oct;181(4):1190-6. doi: 10.1016/j.ajpath.2012.06.014 PMCID: PMC3463623 [full text] [ Epub 2012 Jul 28]
  • Maddatu TP, Grubb SC, Bult CJ, Bogue MA Mouse Phenome Database (MPD) Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. doi: 10.1093/nar/gkr1061 PMCID: PMC3245053 [full text] [ Epub 2011 Nov 18]
  • Murabito JM, Yuan R, Lunetta KL The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals J Gerontol A Biol Sci Med Sci. 2012 May;67(5):470-9. doi: 10.1093/gerona/gls089 PMCID: PMC3326242 [full text]
  • Schofield PN, Vogel P, Gkoutos GV, Sundberg JP Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice Dis Model Mech. 2012 Jan;5(1):19-25. doi: 10.1242/dmm.008334 PMCID: PMC3255539 [full text] [ Epub 2011 Oct 25]
  • Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains Proc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. doi: 10.1073/pnas.1121113109 PMCID: PMC3361401 [full text] [ Epub 2012 May 7]


  • Lorenzo LP, Chen H, Shatynski KE, Clark S, Yuan R, Harrison DE, Yarowsky PJ, Williams MS Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress Antioxid Redox Signal. 2011 Oct 15;15(8):2083-94. doi: 10.1089/ars.2010.3798 PMCID: PMC3166202 [full text] [ Epub 2011 Jun 15]
  • Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178 PMCID: PMC3021372 [full text] [ Epub 2010 Oct 25]
  • Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models Brief Funct Genomics. 2011 Sep;10(5):258-65. doi: 10.1093/bfgp/elr031 PMCID: PMC3189694 [full text]
  • Sher RB, Cox GA, Mills KD, Sundberg JP Rhabdomyosarcomas in aging A/J mice PLoS One. 2011;6(8):e23498. doi: 10.1371/journal.pone.0023498 PMCID: PMC3154500 [full text] [ Epub 2011 Aug 10]
  • Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation Physiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010 PMCID: PMC3068516 [full text] [ Epub 2010 Dec 21]
  • Won J, Marín de Evsikova C, Smith RS, Hicks WL, Edwards MM, Longo-Guess C, Li T, Naggert JK, Nishina PM NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development Hum Mol Genet. 2011 Feb 1;20(3):482-96. doi: 10.1093/hmg/ddq494 PMCID: PMC3016909 [full text] [ Epub 2010 Nov 15]
  • Yuan R, Peters LL, Paigen B Mice as a mammalian model for research on the genetics of aging ILAR J. 2011;52(1):4-15 PMCID: PMC3074346 [full text]


  • Flurkey K, Astle CM, Harrison DE Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1275-84. doi: 10.1093/gerona/glq155 PMCID: PMC2990268 [full text] [ Epub 2010 Sep 5 ]
  • Schofield PN, Gruenberger M, Sundberg JP Pathbase and the MPATH ontology. Community resources for mouse histopathology Vet Pathol. 2010 Nov;47(6):1016-20. doi: 10.1177/0300985810374845 PMCID: PMC3038412 [full text] [ Epub 2010 Jun 29]
  • Sundberg JP, Schofield PN Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbols Vet Pathol. 2010 Nov;47(6):1100-4. doi: 10.1177/0300985810374837 PMCID: PMC3039125 [full text] [ Epub 2010 Aug 4 ]


  • Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels Aging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x PMCID: PMC2768517 [full text] [ Epub 2009 Apr 9 ]