Aging Center Publications

Interventions Testing Program:

• Harrison, D. E., R. Strong, S. Alavez, C. M. Astle, J. DiGiovanni, E. Fernandez, K. Flurkey, M. A. Javors, M. Levi, G. J. Lithgow, F. Macchiarini, J. F. Nelson, S. J. Sukoff Rizzo, T. J. Slaga, T. Stearns, J. E. Wilkinson, R. A. Miller. 2019.Acarbose improves health and lifespan in aging HET3 mice. Aging Cell, 18(2):e12898.. DOI: 10.1111/acel.12898. PMID: 30688027. PMC6413665.

• Miller, R. A., D. E. Harrison, C. M. Astle, M. A. Bogue, J. Brind, E. Fernandez, K. Flurkey, M. Javors, W. Ladiges, C. Leeuwenburgh, F. Macchiarini, J. Nelson, A. G. Ryazanov, J. Snyder, T. M. Stearns, D. E. Vaughan, and R. Strong. 2019.Glycine supplementation extends lifespan of male and female mice. Aging Cell DOI:10.1111/acel.12953. PMID: 30916479. PMC6516426.

• Smith, B. J., R. A. Miller, A. C. Ericsson, D. E. Harrison, R. Strong, T. M. Schmidt. 2019. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. bioRxiv 311456; DOI: 10.1186/s12866-019-1494-7 BMC Microbiology 19:130. PMID: 31195972. PMC6567620.

• Miller, R. A., D. E. Harrison, D. B. Allison, M. Bogue, L. Debarba, V. Diaz, E. Fernandez, A. Galecki., W. T. Garvey, H. Jayarathne, N. Kumar, M. A. Javors, W. C. Ladiges, F. Macchiarini, J. Nelson, P. Reifsnyder,N. A. Rosenthal, M. Sadagurski, A. B. Salmon, D. L. Smith, Jr., J. M. Snyder, D. B. Lombard, R. Strong. 2020.Canagliflozin extends lifespan in genetically heterogeneous male but not female mice. JCI Insight 2020 Sep 29:140019. doi: 10.1172/jci.insight.140019. PMID: 32990681. PMC7710304.

• Strong, R., R. A. Miller, M. Bogue, E. Fernandez, M. A. Javors, S. Libert, P. A. Marinez, M. P. Murphy, N. Musi, J. F. Nelson, M. Petraschec, P. Reifsnyder, A. Richardson, A. B. Salmon, F. Macchiarini,D. E. Harrison. 2020. Rapamycin-mediated mouse lifespan extension: late-life dosage regimes with sex-specific effects. Aging Cell:e13269. https://doi.org/10.1111/acel.13269. PMID: 33145977. PMC7681050.

• Harrison, D. E., R. Strong, P. Reifsnyder, N. Kumar, E. Fernandez, K. Flurkey, M. Javors, M. Lopez-Cruzan, F. Macchiarini, J. F. Nelson, A. Bitto, A. L. Sindler, G. Cortopassi, K. Kavanagh, L. Leng, R. Bucala,N. Rosenthal, A. Salmon, T. M.Stearns, M. Bogue, R. A. Miller. 2021. 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell, Mar 31:e13328. DOI: 10.1111/acel.13328. PMID: 33788371. PMCID: PMC8135004.

• Macchiarini, F., R. A. Miller, R. Strong, N. Rosenthal, D. E. Harrison. NIA interventions testing program: a collaborative approach for investigating interventions to promote healthy aging. 2021. In: Handbook of the Biology of Aging, 9^th Edition. Eds: N. Musi, R. Hornsby. Academic Press. Chapter 10, pp. 219 – 236.

• Bou Sleiman, M., S. Roy, M. C. Sadler, G. V. G. von Alvensleben, H. Li, S. Sen,D. E. Harrison, J. F. Nelson, R. Strong, R. A. Miller, Z. Kutalik, R. W. Williams, J. Auwerx. 2022.Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science 377, eabo3191 (2022). DOI: 10.1126/science.abo3191. PMID: 36173858. PMCID: 9905652.

• Snyder, J. M., K. M. Casey, A. Galecki, D. E. Harrison, H. Jayarathne, N. Kumar, F. Macchiarini, M. Sadagurski, A. B. Salmon, R. Strong, R. A. Miller, and W. Ladiges. 2022.Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. Geroscience, https://doi.org/10.1007/s11357-022-00641-0. PMID 35974129. PMC9886729.

• Strong, R., R. A. Miller, C. J. Cheng, J. Nelson, J. Gelfond, S. Kesaraju Allani, V. Diaz, A. Olsen Dorigatti, J. Dorigatti, E. Fernandez, A. Galecki, B. Ginsburg, K. L. Hamilton, M. A. Javors, K. Kornfeld, M. Kaeberlein, S. Kumar, D. B. Lombard, M. Lopez-Cruzan, B. F. Miller, P. Rabinovitch, P. Reifsnyder,N. A. Rosenthal, M. A. Bogue , A. B. Salmon, Y. Suh, E. Verdin, H. Weissbach, J. Newman, F. Maccchiarini,D. E. Harrison. 2022. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell Sep 30:e13724 http://doi.org/10.1111/acel.13724. PMID: 36179270. PMC9741502.

• Reifsnyder P.C., S. Ryzhov, K. Flurkey, R.P. Anunciado-Koza, I. Mills,D.E. Harrison, R.A. Koza. 2018. Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice. Ann N Y Acad Sci. 2018 Apr;1418(1):106-117. doi: 10.1111/nyas.13557. Epub 2018 Jan 29. PMID: 29377150. PMCID: PMD5934313.

• Reifsnyder P.C., A. Te , D.E. Harrison. 2020. Differential effects of rapamycin on glucose metabolism in nine inbred strains. J Gerontol A Biol Sci Med Sci. 75(1):50-57. PMID: 31276577. PMC6909913.

• Yuan R, C.J.M. Musters, Y. Zhu, T.R. Evans, Y. Sun, E.J. Chesler, L.L. Peters,D.E. Harrison, A. Bartke. 2020. Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. Aging Cell. 2020 Nov; 19(11): e13263. Published online 2020 Oct 26. doi: 10.1111/acel.13263. PMID: 33105070. PMC7681063.

• Reifsnyder P.C., K. Flurkey, R. Doty, N.A. Calcutt, R.A. Koza, D.E. Harrison. 2022. Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice. Aging Cell 21(9):e13666. PMID: 35986566. PMC9470898.

• Willows J.W., M. Robinson, Z. Alshahak, S.K. Morrison, G. Mishra, H. Cyr, M. Blaszkiewicz, G. Gunsch, S. DiPietro, E. Paradie, B. Tero, A. Harrington, L. Ryzhova, L. Liaw, P.C. Reifsnyder,D.E. Harrison, K.L. Townsend. 2023. Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment.Aging Cell. Apr;22(4):e13784. doi: 10.1111/acel.13784. PMID: 36798047. PMC10086534.

Shock Center Publications:

• Keele GR, Zhang JG, Szpyt J, Korstanje R, Gygi SP, Churchill GA, Schweppe DK (2023) Global and tissue-specific aging effects on murine proteomes. Cell Reports 42(7):112715.

• Lee J, Purello C, Booth, SL, Bennett B, Wiley, CD, Korstanje R (2023) Chow diet in mouse aging studies: nothing regular about it. Geroscience in press.

• Karakaslar EO, Katiyar N, Hasham M, Youn A, Sharma S, Chung CH, Marches R,Korstanje R, Banchereau J, Ucar D (2023) Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging. Aging Cell 22(4)e13792.

• Gerdes Gyuricza I, Chick JM, Keele GR, Deighan AG, Munger SC, Korstanje R, Gygi SP, Churchill GA (2022) Genome-wide transcript and protein analysis highlights the role of protein homeostasis in the aging mouse heart. Genome Research 32(5):838-852.

• Lee J, Davis Ian, Youth EHH, Kim J, Churchill G, Godwin J, Korstanje R, Beck S (2021) Misexpression of genes lacking CpG islands is a hallmark of aging. Science Advances In press.

• Korstanje R, Peters LL, Krasinski SD, Churchill GA (2021) The Jackson Laboratory Nathan Shock Center: Impact of Genetic Diversity on Aging. GeroScience.

• Palliyaguru DL, Shiroma EJ, Nam JK, Duregon E, Vieira Ligo Teixeira C, Price NL, Bernier M, Camandola S, Vaughan KL, Colman RJ, Deighan A,Korstanje R, Peters LL, Dickinson SL, Ejima K, Simonsick EM, Launer LJ, Chia CW, Egan J, Allison DB,Churchill GA, Anderson RM, Ferrucci L, Mattison JA, de Cabo R (2021) Fasting blood glucose as a prediction of mortality: Lost in translation. Cell Metabolism S1550-4131(21).

• Liao CM, Wulfmeyer V, Swallow M, Falk C, Haller H, Korstanje R, Melk A, Schmitt R (2021) Induction of Renal Cellular Senescence in Vitro: Impact of Mouse Strain Genetic Diversity. Cells 10(6):1437.

• Bitto A, Lee MB, Hill CM, Korstanje R, Kaeberlein M (2021) The AGE Presents Introduction to Geroscience video lecture series. Geroscience. 43(4):1697-1701.

• Takemon Y, Chick JM, Gyuricza IG, Skelly DA, Devuyst O, Gygi SP,Churchill GA, Korstanje R. (2021) Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney. eLife. 10:e62585.

• Bouteldja N, Klinkhammer BM, Bülow RD, Droste P, Otten SW, Freifrau von Stillfried S, Moellmann J, Sheehan SM,Korstanje R, Menzel S, Bankhead P, Mietsch M, Drummer C, Lehrke M, Kramann R, Floege J, Boor P, Merhof D. (2021)Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology. Journal of the American Society of Nephrology 32(1):52-68.