Jackson Laboratory
  • Research & Faculty 
    • Overview
    • Where We Work
      • JAX Mammalian Genetics
      • JAX Genomic Medicine
    • A-Z Faculty Listing
    • A-Z Research Labs
    • Data Science at JAX
    • Tools and Resources
    • Research Centers
    • Careers
  • Education & Learning 
    • Education & Learning Home
    • Online Learning
    • Courses
      • In Person & Virtual
      • Online MiniCourses
      • Bioinformatics Training Program
    • Clinicians
      • Clinical Topics
      • Course Offerings
      • Cancer Genetic Clinical Education
      • Precision Medicine for Your Practice
    • Postbacc, Ph.D., and Postdoctoral Programs
      • Cooperative Ph.D. Training
      • Postdoctoral Associates
      • Postbacc Fellows
      • Postbaccalaureate Research
    • Students & Teachers
      • Maine State Science Fair
      • Summer Student Program
      • Academic Year Fellowships
      • Teacher Professional Development
      • Genetics Learning Resources
      • College Scholarship
  • Jax Mice & Services 
    • Innovative Research
      • Breakthrough Lab
      • Research Resiliency
    • Find Mice & Biospecimens
      • Why JAX Mice
      • Search JAX Mice
      • Order JAX Mice
      • Biospecimens
    • Services for Mice
      • Custom Model Generation
      • Cohort Expansion & Breeding
      • Surgical Services
      • Cryo and Strain Donation
    • In Vivo Pharmacology
      • Oncology
      • PDX Models
      • Humanized Mice
      • Neurobiology
      • Immunology
      • Antibody Evaluation
      • Safety and Efficacy Studies
    • Disease Area
      • Cardiovascular
      • Immunology
      • Metabolic Diseases
      • Neurobiology
      • Oncology
      • Rare Diseases
    • Customer Resources
      • Customer Service
      • Technical Help
      • Resource Center
    • Virtual Events
      • Explore Immunology
      • Explore Neurobiology Solutions
      • Explore Oncology
      • Discover JAX
      • Webinars
  • Personalized Medicine 
    • What is Personalized Medicine?
      • Genetics vs. genomics
      • Ethical considerations
      • Personalized medicine and you
      • What is CRISPR?
    • Mice in Biomedical Research
    • Areas of Research
      • Addiction
      • Aging
      • Alzheimer's & Other Dementias
      • Cancer
      • Diabetes
      • Microbiome
      • Rare diseases
      • Vision
    • Clinical Knowledgebase
    • Maine Cancer Genomics Initiative
  • News 
    • JAX News
    • JAX Blog
    • Minute to Understanding
    • Subscribe
    • Press Room
    • The Search Magazine
    • Explore by Topic
  • About Us 
    • Fast Facts
    • Our Culture
      • Our Values
      • Diversity, Equity & Inclusion
      • Our Leaders
      • Where We Work
      • Work With Us
    • Our Impact
      • Our Medical Impact
      • Our Economic Impact
      • Our Community Impact
      • Our Environmental Impact
    • Our History
    • Careers
    • Contact Us
  • Give
  • JAX Home
  • Research and Faculty
Lihong Zhao, Associate Research Scientist

Lihong Zhao, Ph.D.

Project Scientist

Bar Harbor, ME

Conducts research on neurological diseases and genetic modifiers.

  • Developmental Biology
  • Aging
  • Genetics and Genomics
  • Computational Biology
  • Developmental Disorders
  • Neurodegenerative and Neuromuscular Diseases
  • Complex Traits
  • Aging
  • Behavioral Disorders

Contact me at: 207-288-6000

Connect with me:

Thank you. Your message has been sent.

Contact Lihong Zhao, Ph.D.





reCAPTCHA helps prevent automated form spam.
The submit button will be disabled until you complete the CAPTCHA.


About Lihong Zhao, Ph.D.

My first research program focuses on the regulation of the de novo ceramide biosynthesis pathway that determines cellular profiles of sphingolipid metabolites, i.e. sphingoid long-chain bases (LCBs) and ceramide (acylated LCB) species, which have been implicated in many neurological diseases. Using mouse models generated in The Jackson Laboratory or contributed to the mouse depository at The Jackson Laboratory, I have been working toward elucidating the potentially specific neural functions and pathological roles of different LCBs and ceramides, respectively, in two related projects.My second research program focuses on the transcription network controlling photoreceptor differentiation and how deregulation of this network causes photoreceptor degeneration. We adopted a genetic approach to identify novel regulators of this network by searching for genetic modifiers of rd7, a mutation of the transcription factor NR2E3 causing a retinopathy called Enhanced S-Cone Syndrome. We have found several modifiers that suppress rd7. Currently, we are trying to identify the underlying genes and assess their interactions with other genes’ encoding factors involved in photoreceptor differentiation.

  • Press ReleaseMay 09, 2016

    New insight in sphingolipid formation reveals neurodegenerative process

    New understanding of how a class of lipids called sphingolipids are formed could shed light on mechanisms of epilepsy, dementia and other neurodegenerative diseases, paving the way to new treatment approaches, according to Jackson Laboratory (JAX) researchers and their collaborators.
    • Neurodegenerative Disease
    • Neurodegenerative and Neuromuscular Diseases

Space

Quick Links

  • Contact
  • Donate
  • Subscribe

Utility Menu

  • JAX Home
  • Careers
  • Legal Information
  • Research Centers
  • Mouse Genome Informatics
  • Mouse Phenome Database

Leading the search fortomorrow's cures

Follow

Follow on Facebook Follow on Twitter Follow on LinkedIn Follow on YouTube Follow on Instagram

©2021 The Jackson Laboratory

We use cookies to personalize our website and to analyze web traffic to improve the user experience. You may decline these cookies although certain areas of the site may not function without them. Please refer to our privacy policy for more information.

Settings

Allow essential cookies

Required for basic site operations.

Allow analytics cookies

Used to analyze web traffic to improve the user experience.

Allow marketing cookies

Used to deliver personalized information and tailor communications.

Save and close