STZ-Induced Diabetes

Streptozotocin (STZ) is an alkylating agent that targets insulin-producing beta cells in the pancreas, mimicking Type 1 diabetes phenotypes in mice. Propel your preclinical research using JAX inventoried, on-demand, and unique STZ-injected models generated on various genetic backgrounds, as well as additional services available to researchers worldwide.

Key benefits

  • Diabetes is induced in C57BL/6J, NOD-scid, and NSG male mice using validated protocols
  • An inventory of C57BL/6J males expedites access to diabetic mice
  • No need to handle STZ: we safely dispose of the harmful chemical and only provide mice with non-fasting blood glucose exceeding 250 mg/dL

Capabilities

  • Diabetic mice are available at 7-9 weeks of age
  • Customizable options using other JAX strains, different doses, and more, after our feasibility assessment
  • Diabetes can be induced in nude mice, including outbred J:NU males and inbred NU/J males & females
  • We can also inject neonatal C57BL/6J pups for non-alcoholic steatohepatitis (NASH) research and other projects
  • Diabetes modeling can be integrated with Efficacy Testing Services and histology services as needed

STZ Induction Statisticsa

Glucose range
(mg/dL)
C57BL/6J NOD scid NSG
250 - 349 26% 14% 8%
350 - 449 43% 18% 32%
> 450 31% 67% 57%
Average Glucose +/- St Dev (# Mice) 414 +/- 93 (1573) 484 +/- 92 (49) 473 +/- 91 (73)

a Non-fasting glucose was measured 14-16 days after the first injection. Data are for guidance only.

Additional phenotypic data from STZ-induced C57BL/6J, NOD scid, and NSG mice.

STZ-Induced Diabetes: FAQ

STZ-Induced Diabetes: FAQ

Phenotypes of STZ Mice

Phenotypes of STZ Mice