Key benefits
- Diabetes is induced in C57BL/6J, NOD-scid, and NSG male mice using validated protocols
- No need to handle STZ: we safely dispose of the harmful chemical and only provide mice with non-fasting blood glucose exceeding 250 mg/dL
Capabilities
- Diabetic mice are available at 7-9 weeks of age
- Customizable options using other JAX strains, different doses, and more, after our feasibility assessment
- Outbred J:ARC(S) males respond to STZ with the highest blood glucose of any strain tested to date
- Diabetes can be induced in nude mice, including outbred J:NU males and inbred NU/J males & females
- We can also inject neonatal C57BL/6J pups for non-alcoholic steatohepatitis (NASH) research and other projects
- Diabetes modeling can be integrated with Efficacy Testing Services and histology services as needed
STZ Induction Statisticsa
| Glucose range (mg/dL) |
C57BL/6J | NOD scid | NSG |
|---|---|---|---|
| 250 - 349 | 26% | 14% | 8% |
| 350 - 449 | 43% | 18% | 32% |
| > 450 | 31% | 67% | 57% |
| Average Glucose +/- St Dev (# Mice) | 414 +/- 93 (1573) | 484 +/- 92 (49) | 473 +/- 91 (73) |
a Non-fasting glucose was measured 14-16 days after the first injection. Data are for guidance only.
Additional phenotypic data from STZ-induced C57BL/6J, NOD scid, and NSG mice.
