JAX Frontend Platform

Comparison of Widely Used JAX Mice for Type 2 Diabetes and Obesity

This table compares the major type 2 diabetes and obesity phenotypes among humans and key models. Clicking on a model takes you to information detailing major phenotypes and important references.

Diabetes Phenotype

PhenotypesHumans
B6.Cg-Lepob/J
B6.BKS(D)-Leprdb/J (000697)
BKS.Cg-Dock7m +/+
Leprdb/J
C57BL/6J DIO
TALLYHO/JngJ
KK.Cg-Ay/J
NEW!
MSNASH/PcoJ
Induced or spontaneousSpontaneousSpontaneousSpontaneousDiet-inducedSpontaneousSpontaneousSpontaneous
GeneticsPolygenicPolygenicPolygenicPolygenicPolygenicPolygenicPolygenic
OnsetMature (progressive)YoungYoungMatureMatureMatureMature
SexM, FM, FM, FMMM, FM
HyperinsulinemiaModerateSevereModerate (transient)MildYesSevereYes
Glucose intoleranceYesYesYesYesYesYesYes
HyperglycemiaYesModerate (transient)SevereMild / ModerateYesYesModerate
Islet atrophyVariableNo (hyperplasia only)YesNoYes (late onset)HypertrophyUnknown
Impaired wound healingYesYesYesYesUnknownUnknownUnknown
NephropathyYesNoYes (mild)NoUnknownYesUnknown

Obesity Phenotypes

PhenotypesHumans
B6.Cg-Lepob/J
B6.BKS(D)-Leprdb/J (

000697)

BKS.Cg-Dock7m +/+
Leprdb/J
C57BL/6J DIO
TALLYHO/JngJ
KK.Cg-Ay/J
NEW!
MSNASH/PcoJ
Induced or spontaneousSpontaneousSpontaneousSpontaneousDiet-inducedSpontaneousSpontaneousSpontaneous
GeneticsPolygenicMonogenicMonogenicPolygenicPolygenicMonogenicPolygenic
OnsetVariableYoungYoungMatureJuvenileMatureYoung
SexM, FM, FM, FMM, FM, FM
DegreeModerateSevereSevereSevereModerateModerateModerate
HypertriglyceridemiaYesYesYesMildYesYesYes
Leptin/leptin receptor axisNormalDisruptedDisruptedNormalNormalNormalIntact
HyperphagiaNoYesYesMildNoYesNo
HypercorticismNoYesYesNoUnknownNoUnknown
Thermoregulatory defectsNoYesYesUnknownNoUnknownNo
Liver steatosisVariableSevereSevereUnknownModerateModerateDiet-induced

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