This table compares the major type 2 diabetes and obesity phenotypes among humans and key models. Clicking on a model takes you to information detailing major phenotypes and important references.
Diabetes Phenotype
| Phenotypes | Humans | B6.Cg- (000632) B6.BKS(D)-Leprdb/J (000697) | BKS.Cg- Leprdb/J (000642) | C57BL/6J DIO (000664) | TALLYHO/JngJ (005314) | KK.Cg- (002468) | NEW! MSNASH/PcoJ (030888) |
|---|---|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced | Spontaneous | Spontaneous | Spontaneous |
| Genetics | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic |
| Onset | Mature (progressive) | Young | Young | Mature | Mature | Mature | Mature |
| Sex | M, F | M, F | M, F | M | M | M, F | M |
| Hyperinsulinemia | Moderate | Severe | Moderate (transient) | Mild | Yes | Severe | Yes |
| Glucose intolerance | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Hyperglycemia | Yes | Moderate (transient) | Severe | Mild / Moderate | Yes | Yes | Moderate |
| Islet atrophy | Variable | No (hyperplasia only) | Yes | No | Yes (late onset) | Hypertrophy | Unknown |
| Impaired wound healing | Yes | Yes | Yes | Yes | Unknown | Unknown | Unknown |
| Nephropathy | Yes | No | Yes (mild) | No | Unknown | Yes | Unknown |
| Phenotypes | Humans | B6.Cg- (000632) B6.BKS(D)-Leprdb/J ( | BKS.Cg- Leprdb/J (000642) | C57BL/6J DIO (000664) | TALLYHO/JngJ (005314) | KK.Cg- (002468) | NEW! MSNASH/PcoJ (030888) |
|---|---|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced | Spontaneous | Spontaneous | Spontaneous |
| Genetics | Polygenic | Monogenic | Monogenic | Polygenic | Polygenic | Monogenic | Polygenic |
| Onset | Variable | Young | Young | Mature | Juvenile | Mature | Young |
| Sex | M, F | M, F | M, F | M | M, F | M, F | M |
| Degree | Moderate | Severe | Severe | Severe | Moderate | Moderate | Moderate |
| Hypertriglyceridemia | Yes | Yes | Yes | Mild | Yes | Yes | Yes |
| Leptin/leptin receptor axis | Normal | Disrupted | Disrupted | Normal | Normal | Normal | Intact |
| Hyperphagia | No | Yes | Yes | Mild | No | Yes | No |
| Hypercorticism | No | Yes | Yes | No | Unknown | No | Unknown |
| Thermoregulatory defects | No | Yes | Yes | Unknown | No | Unknown | No |
| Liver steatosis | Variable | Severe | Severe | Unknown | Moderate | Moderate | Diet-induced |