Comparison of widely used JAX Mice for
type 2 diabetes and obesity

This table compares the major type 2 diabetes and obesity phenotypes among humans and key models.
Clicking on a model takes you to information detailing major phenotypes and important references.


Diabetes Phenotypes


 

Humans and Mouse Models (Stock number)

Phenotypes

Humans

B6.Cg-Lepob/J
(000632)

B6.BKS(D)-Leprdb/J (000697)

BKS.Cg-Dock7m +/+ Leprdb/J
(000642)

C57BL/6J DIO
(000664)

TALLYHO/JngJ
(005314)

KK.Cg-Ay/J
(002468)

NEW!
MSNASH/PcoJ
(030888)

Induced or spontaneous Spontaneous Spontaneous Spontaneous Diet-induced Spontaneous Spontaneous Spontaneous
Genetics Polygenic Polygenic Polygenic Polygenic Polygenic Polygenic Polygenic
Onset Mature
(progressive)
Young Young Mature Mature Mature Mature
Sex M, F M, F M, F M M M, F M
Hyperinsulinemia Moderate Severe Moderate (transient) Mild Yes Severe Yes
Glucose intolerance Yes Yes Yes Yes Yes Yes Yes
Hyperglycemia Yes Moderate
(transient)
Severe Mild / Moderate Yes Yes Moderate
Islet atrophy Variable No
(hyperplasia only)
Yes No Yes (late onset) Hypertrophy Unknown
Impaired wound healing Yes Yes Yes Yes Unknown Unknown Unknown
Nephropathy Yes No Yes (mild) No Unknown Yes Unknown

Obesity Phenotypes


 

Humans and Mouse Models (Stock number)

Phenotypes

Humans

B6.Cg-Lepob/J
(000632)

B6.BKS(D)-Leprdb/J (000697)

BKS.Cg-Dock7m +/+ Leprdb/J
(000642)

C57BL/6J DIO
(000664)

TALLYHO/JngJ
(005314)

KK.Cg-Ay/J
(002468)

NEW!
MSNASH/PcoJ
(030888)

Induced or spontaneous Spontaneous Spontaneous Spontaneous Diet-
induced
Spontaneous Spontaneous Spontaneous
Genetics Polygenic Monogenic Monogenic Polygenic Polygenic Monogenic Polygenic
Onset Variable Young Young Mature Juvenile Mature Young
Sex M, F M, F M, F M M, F M, F M
Degree Moderate Severe Severe Severe Moderate Moderate Moderate
Hypertriglyceridemia Yes Yes Yes Mild Yes Yes Yes
Leptin/leptin receptor axis Normal Disrupted Disrupted Normal Normal Normal Intact
Hyperphagia No Yes Yes Mild No Yes No
Hypercorticism No Yes Yes No Unknown No Unknown
Thermoregulatory defects No Yes Yes Unknown No Unknown No
Liver steatosis Variable Severe Severe Unknown Moderate Moderate Diet-induced