Type 1 Diabetes

Type 1 Diabetes Efficacy Studies

In Vivo Pharmacology Services at JAX performs contract efficacy studies using NOD/ShiLtJ (001976) mice to evaluate new Type 1 diabetes-related therapeutics

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NOD (001976)

Autoimmune destruction of pancreatic beta cells causes type 1 diabetes with a female bias

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Akita (003548)

A mutation destabilizing insulin causes rapid insulin-dependent diabetes with a male bias

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STZ-Induced Diabetes

Chemical depletion of pancreatic beta cells mimics the end stages of type 1 diabetes in C57BL/6J, NOD scid, NSG™ and other strains.

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