Lupus Disease Models

Lupus Efficacy Studies

Let In Vivo Pharmacology Services at JAX perform your lupus-related efficacy study using robust systemic lupus erythematosus (SLE) mouse models

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MRL-lpr (000485)

Defective immune tolerance causes SLE in males and females of this thoroughly characterized lupus model

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Disease characteristics of MRL-lpr

Detailed phenotypes of the MRL-lpr lupus model

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BXSB/MpJ (000740)

SLE develops in males due to a Y-linked mutation that dysregulates immune signaling

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NZBWF1/J (100008)

Abnormal immune responses underlie a SLE model with a female bias seen in the human disease

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