The human breast cancer microenvironment displays features of T helper 2 (Th2) immunity, which
promotes tumor development. We showed that breast cancer cell-derived thymic stromal lymphopoietin
(TSLP), by inducing OX40L expression on DCs, contributes to the Th2 immunity conducive to breast tumor
In order to reprogram the inflammatory pro-tumor Th2 (iTh2) into anti-tumor Th1 microenvironment, we
tested the impact of targeting the innate receptors on DCs to render the resistant to tumor environment.
We show that intratumoral delivery of β-glucan, a natural ligand for dectin-1 expressed on DCs, blocks the
generation of iTh2 cells leading to decreased IL-13 in the tumor microenvironment and prevents breast
cancer development. β-glucan exposed DCs expand CD8+ T cells, which produce higher IFNg, Granzyme A
and Granzyme B, accumulate in the tumors leading to enhanced tumor necrosis in vivo. Our data
demonstrate that exploiting pattern-recognition receptors on tumor-infiltrating DCs enables cancer
We are further exploring the ATACseq and RNAseq approach to understand the regulation of TSLP
production in breast tumor cells and how TSLP alters the infiltrating DCs. It can be novel molecular biology
approaches to decode tumor infiltrating DCs and T cells and define potential targets for immunotherapy.
University of Arizona researcher George Sutphin had never touched a mouse before he arrived as a postdoctoral associate in the Korstanje lab at The Jackson Laboratory. Now he depends on the mouse and other models as he works to develop new clinical interventions to extend healthy human lifespan and treat age-associated disease.
New research is providing a better understanding of the processes underlying cell-to-cell differences within glioblastoma tumors — a crucial finding because these differences contribute to therapy resistance.
JAX Associate Professor Jeffrey Chuang, Ph.D., has been awarded a five-year grant totaling $2,650,484 from the National Cancer Institute for research that could pave the way for the first evolution-based approaches to cancer treatment.
At JAX's new speaker event series, JAXtaposition, two scientific leaders shared how the Maine Cancer Genomics Initiative and JAX’s cutting-edge genomic testing is giving physicians access to the most advanced precision cancer care for their patients.