Laurent Bogdanik, Ph.D., M.B.A.

Study Director

Developing and optimizing mouse models for neurological disorders, researching the mechanisms of brain and muscle diseases, and supporting drug discovery with preclinical research services.

Too often, promising therapeutic candidates in animal models show no efficacy in patients; how can we refine preclinical drug development in mice to hasten the discovery of cures? This is the task we take on every day. My team specializes on muscle and nerve diseases, including Muscular Dystrophies and Amyotrophic Lateral Sclerosis (ALS); we also collaborate on rare childhood neurological conditions such as Rett Syndrome or lipid and lysosomal storage disorders. We work at three stages of the drug discovery process. Upstream, we research the origins and mechanisms of the diseases by creating and studying new mouse strains that replicate the genetic mutations found in patients, specifically in ALS, Charcot-Marie-Tooth Diseases and Congenital Myasthenic Syndromes. On more established mouse models, we search and refine the best biomarkers that are truly informative of the progression of the disease and can be used in drug efficacy studies, for instance electrophysiology. Lastly, we use this knowledge of the models and best assays, to provide preclinical services and support drug development by academics, biotechs and pharmas. I am honored to have been supported, over the years, by patient foundations, and to have worked with companies who brought the first-ever approved therapy to SMA patients.

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Education and experience

Education

Husson University
Master of Business and Administration
2013-2016

The Jackson Laboratory
Postdoctoral fellow
Adv: Pr. Robert Burgess
2006-2011

Universite de Montpellier II (France)
Ph.D., Neurobiology
Adv: Prof. Joel Bockaert
2001-2006

Universite de Montpellier II (France)
M.S., Neurobiology

Universite de Toulouse III (France)
B.A., Physiology
1998-2000

Experience

in vivo pharmacology services, The Jackson Laboratory
Study Director
2015-present

Genetic Resource Science, Lutz Laboratory, The Jackson Laboratory
Associate Research Scientist
2012-2015

The Jackson Laboratory, Burgess Lab
Associate Research Scientist
20011-2012

Universite de Montpellier II (France)
Lecturer, Animal Physiology
2001-2004