Investigating the impact of structural variation on complex disorders and their evolution. Studying the bilateral translation of human genomic findings to mice.
I study the genetics of complex diseases in humans, with focus on neuropsychiatric and metabolic disorders. I am particularly interested in investigating the polygenic nature of traits, pleiotropy and the missing heritability. A substantial part of my study focuses on population genetics, historical genetics, archaeogenomics, and the evolutionary history of modern humans, along with their implication for diseases and traits in modern humans.
At JAX I am focusing on identifying the contribution of structural variation to the heritability of complex disorders, the evolutionary and population genetics aspects of structural variation, and the bilateral translation of human genetic findings to mice.