March 25, 2020Updated June 29, 2020 at 3:20 PM
Expediting COVID-19 research
Joyce Dall'Acqua Peterson
Building a colony of hACE2 mice for COVID-19 research
JAX has created a new colony of specialized hACE2 mice to support global research on COVID-19. hACE2 mice are available for order, and JAX will begin shipping in June 2020.
The Jackson Laboratory is delivering a unique transgenic mouse model to the world’s research community
The world is waiting for vaccines and treatments to mitigate the spread and severity of the coronavirus COVID-19 pandemic. The Jackson Laboratory (JAX) is working to ensure that the worldwide research community has access to a mouse model that can serve as an accurate experimental platform for COVID-19.
“Right now, we're going from zero to a hundred miles an hour,” Lutz says. “We started with getting a small vial of sperm from Stanley Perlman, who very generously and very graciously understood the urgency of the situation and released that to us immediately. He then released another 15 vials that we got from his laboratory.”
To generate sufficient quantities of the K18-hACE2 mice, the JAX team immediately initiated a large-scale in vitro fertilization (IVF) program. “We are extremely fortunate to have reproductive science capabilities that far extend our capacity to generate these mice by just natural mating,” Lutz explains. “Natural mating involves putting a male and a female into a cage, giving them some time to get to know each other, and producing a small litter of pups of maybe five or six animals.”
By using IVF alongside traditional breeding, JAX has generated a new colony of hACE2 mice. The colony can now be sized to meet the demands of researchers around the world.
Preliminary data, from multiple independent research institutions that have recently received cohorts of hACE2 mice from JAX, indicate that the mice are not only capable of infection by SARS-CoV-2, but also lose body weight as a result of a sustained infection that is lethal in these mice. This is similar to the results from previous research seen with SARS-CoV infection. Moreover, genetically identical mice that did not receive the virus show no signs of illness.
Lutz notes that all this extraordinary effort is more expensive to conduct than traditional breeding. “But one thing that we have committed ourselves to doing is to making sure that the price of the mice is as low as it can possibly be. This is very much in line with our nonprofit mission. We do want to lend some reassurance to the users of these animals that we are providing them not only as quickly as possible, but as cost-effectively as we possibly can, so that they can maximize the use of these animals in their research.” Thanks to the cooperation of the University of Iowa, JAX is also keeping licensing costs associated with the mice to a minimum.
Besides the efforts to breed and distribute enough K18-hACE2 mice to meet demand, JAX is reviewing other mouse models for their potential to advance COVID-19 research.
Lutz adds, “I think that the work we're doing with COVID-19 really speaks to the strengths of The Jackson Laboratory. I don't imagine that there are many institutions who could be called into action in the way that we have been, and responded as quickly as we have. We certainly have an excellent staff of individuals. Our nonprofit mission resonates throughout the institution, especially at times of crises like these. And I think we feel very privileged to be able to participate and facilitate the work that really needs to happen, to get the country and the world through this crisis at this time.”
COVID-19 interview with JAX President Edison Liu
Dr. Liu talks scientifically about the origins of the virus that causes COVID-19. He also describes how a mouse model was developed to enable research into the disease.