Human CD34+ hematopoietic stem cell-engrafted NSG™ mice (hu-CD34) develop multi-lineage human immune cells, and are a validated platform for immuno-oncology efficacy studies, and infectious disease research. Our inventory has CD34+ mice available for immediate shipment to your facility or efficacy study enrollment at ours.
Humanized CD34+ mice are supreme in vivo models to study immuno-oncology, infectious diseases and graft rejection research. This model has the longest research span, over 12 months with a functional human immune system displaying T-cell dependent inflammatory responses with no donor cell immune reactivity towards the host.
Hu-CD34+ mice produced by injecting CD34+ hematopoietic stem cells (hu-CD34) demonstrate robust multi-lineage engraftment of human immune cell populations including very good T cell maturation and function for long-term studies. NSG™ mice engrafted with human CD34+ The NOD scid gamma (NSG™) recipient mouse, developed by JAX Professor Lenny Shultz, has been shown to support greater engraftment of human hematopoietic stem cells (hu-CD34+ cells) than all other currently available strains (McDermott et al. 2010).
Female mice are injected with human hematopoietic stem cells (hu-CD34+). Engraftment of mature human white blood cells (hCD45+) is confirmed 16 weeks after injection. Any mouse with more than 25% hCD45+ cells is considered successfully humanized.
Hu-CD34-NSG™ and hu-CD34-SGM3 are ideal for long-term in vivo studies in the areas of immuno-oncology, infectious diseases and graft rejection research -since their lifespan after CD34+ engraftment is over 12 months.
These preclinical models are also used as platforms for screening efficacy of genetically modified stem cells (Kitchen et al. 2012).
Study-ready cohorts of inventoried humanized CD34+ mice are readily available for shipment to your institution or for enrollment in customized drug efficacy studies executed by our experienced Ph.D. level scientists from JAX In Vivo Services.
Director, Technology Transfer
The Jackson Laboratory
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