Human CD34+ hematopoietic stem cell-engrafted NSG™ or NSG™ variant mice (hu-CD34) develop multi-lineage human immune cells, and are a validated platform for immunology or immuno-oncology efficacy studies, and infectious disease research. Our inventory has CD34+ mice available for immediate shipment to your facility or efficacy study enrollment at ours.
Humanized CD34+ mice are supreme in vivo models to study immunology, infectious diseases, and more. For example, NSG™engrafted models offer the longest research span, over 12 months with a functional human immune system displaying T-cell dependent inflammatory responses with no donor cell immune reactivity towards the host.
Hu-CD34+ mice produced by injecting CD34+ hematopoietic stem cells (hu-CD34) demonstrate robust multi-lineage engraftment of human immune cell populations including very good T cell maturation and function for long-term studies. JAX has been the pioneer of developing cutting-edge immunodeficient strains such as the NSG™ models and its variants to enable powerful research.
Female mice are injected with human hematopoietic stem cells (hu-CD34+). Engraftment of mature human white blood cells (hCD45+) is confirmed approximately 2 months after injection.
Successful humanization of each mouse is quantified from mouse peripheral blood via flow cytometry using anti- hu-CD45+ and anti-murine CD45+, approximately 2 months post-engraftment, when mature T-cells develop (Ishikawa et al. 2005). All mice ship with >25% hu-CD45+ cells in the peripheral blood.
Study-ready cohorts of inventoried humanized CD34+ mice are readily available for shipment to your institution or for enrollment in customized drug efficacy studies executed by our experienced Ph.D. level scientists from JAX In Vivo Services. The models readily available include: NSG, NSG-SGM3, NSG-IL15; custom models are available on-demand (for a list of NSG variants, click here).
We distribute NSG™ mice under an agreement with the NIH. NSG™ mice are available to non-profit research institutions under an MTA. Companies and for profit entities require a no-fee license prior to shipping. Many companies already have a license that includes engrafted NSG™ mice. To confirm that your company is covered or for new license inquiries, please contact:
Director, Technology Transfer
The Jackson Laboratory
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