JAX researchers find that reducing Hp1bp3 expression mimics age-related cognitive decline through mechanisms reminiscent of aging and Alzheimer's disease
Inheriting a specific genetic variant, APOEε4, is linked with 15-20 percent rise in risk of developing Alzheimer’s, with at least 20 other genes implicated. JAX researchers are studying how APOEε4 risk depends on other genes, in mice with a wide variety of genetic backgrounds.
Learn how JAX scientists are redefining Alzheimer’s in order to search for cures for the devastating disease.
The Alzheimer’s Association has awarded a three-year research fellowship to Amy Dunn, Ph.D., a postdoctoral associate in the Kaczorowski lab, for her studies of how genetics and diet interact to determine risk for Alzheimer’s disease.
For the first time, researchers have the tools to build new mouse models that truly represent patients with Alzheimer’s disease.
A new genetically diverse mouse population is opening possibilities for translational research into Alzheimer’s disease that accurately recreates human disease symptoms and progression.
Late-onset Alzheimer’s disease is extremely difficult to model in the laboratory, one reason why no successful therapy for it exists. But scientists are using new capabilities to create more accurate, more useful research tools, bringing new hope for progress and better outcomes for patients.
Indiana University-Jackson Laboratory MODEL-AD Center addresses critical need for precision animal models for Alzheimer’s research.
Alzheimer’s disease is still poorly understood despite its huge costs and burden. Greg Carter is working at the intersection between patient and mouse research to develop accurate disease models and develop effective therapies.
Tackling Alzheimer's disease in the laboratory, clinic and life.