HuMM Agreement - Schedule A

Schedule "A" (updated August 4th, 2023)

Description of MICE

11066 (NSG-Porcine tg) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2YgyTg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ,^f

12479 (NSG-DRA4) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckRolyJ,^{c f}

12480 (NSG-Hprt) - NOD.Cg-Prkdcscid Il2rgtm1Wjl Hprtb-m3/EshJ,^fg

14553 (NSG hHGFki) NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J,^{f l}

17637 (NSG Ab1 DLR4) NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Doi Tg(HLA-DRB1)31Dmz/SzJ,^f

17914 (NRG-DRA, DRAG Mouse) NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/ScasJ,^{e i j}

18454 (NRG FAH) NOD.Cg-Rag1^tm1Mom Fah^em1Mvw Il2rg^tm1Wjl/MvwJ, ^{e f a4}

21885 (NSG-Ab^o) NOD.Cg-Prkdc^scid H2-Ab1^tm1Doi Il2rg^tm1Wjl/SzJ

21937 (NSG-GFP) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ,^f

25730 (B6-RCd47g) B6.129S-Rag2tm1Fwa Cd47tm1Fpl Il2rgtm1Wjl/J,^{f n o}

26014 (NRG-W-Kit 41 Eaves) NOD.Cg-Rag1^tm1Mom Kit^W-41J Il2rg^tm1Wjl/EavJ, ^{e f}

26497 (NSG-W-Kit41 Wask) NOD.Cg-Kit^W-41J Prkdc^scid Il2rg^tm1Wjl/WaskJ,^t

26561 (NSG-DQ8) NOD.Cg-Prkdc^scid H2-Ab1^tm1Doi Il2rg^tm1Wjl Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ,^r

26936 (NSG-DQ8 INS) NOD.Cg-Prkdc^scid H2-Ab1^tm1Doi Il2rg^tm1Wjl Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(INS*)172Dvs/DvsJ, ^r

26997 (NSG CD68) NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(CD68-EGFP)1Drg/J,^{f u}

27905 (NSG-Cd274) NOD.Cg-Prkdc<scid> Cd274<tm1Shr> Il2rg<tm1Wjl>/J,^{f v}

27976 (NSG-RIP DTR) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(Ins2-HBEGF)6832Ugfm/SzJ,^{f q}

29295 (NSG DR4) NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/SzJ,^r

29663 (NRG Dysf) NOD.Cg-Rag1^tm1Mom Dysf^prmd Il2rg^tm1Wjl/McalJ, ^{e f}

29819 (NSG Gcg1-29KO) NOD.Cg-Gcg^em1Dvs Prkdc^scid Il2rg^tm1Wjl/DvsJ,^{m f}

30331 (NSG-DRA1) NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdc^scid H2-Ab1^tm1Doi Il2rg^tm1Wjl/SzJ,^{c f}

30442 (NRG-mdx) NOD.Cg-Rag1^tm1Mom Dmd^mdx-4Cv Il2rg^tm1Wjl/McalJ,^{e w}

30443 (NRG-Sgca) NOD.Cg-Rag1^tm1Mom Sgca^tm1Kcam Il2rg^tm1Wjl/McalJ,^{e w}

30533 (NRG hNTCP) NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(SLC10A1)15Mvw/MvwJ,^{f e a1}

30547 (NSG C I/II B2m) NOD.Cg-B2m^tm1Unc Prkdc^scid H2^dlAb1-Ea1 Il2rg^tm1Wjl/SzJ,^f

30610 (NSG-CYbb) NOD.Cg-Prkdcscid Cybbem1Hmal Il2rgtm1Wjl/HmalJ,^{f m y}

31566 (NSG Abo DR4) NOD.Cg-Prkdc^scid H2-Ab1^tm1Doi Il2rg^tm1Wjl Tg(H2-Ea-HLA-DRB1*0401*)1Dv/SzJ,^r

31900 (NSG-cmah) NOD.Cg-Cmah^em1Guru Prkdc^scid Il2rg^tm1Wjl/GuruJ,^a5

32474 (NSG-SGM3-Abcd1^Δ89) NOD.Cg-Prkdc^scid Abcd1^em2Lutzy Il2rg^tm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ,^{b f  m}

32927 (NSG DKO) NOD.Cg-Prkdc^scid H2-K1^em1Dvs H2-Ab1^em1Dvs H2-D1^em5Dvs Il2rg^tm1Wjl/SzJ, ^m

33127 NOD.Cg-Rag1^tm1Mom Flt3^tm1Irl Mcph1^{Tg(HLA-A2.1)1Enge} Il2rg^tm1Wjl/J,^def

34569 (NSG.Otc^R129H) NOD.Cg-Prkdc^scid Otc^em1Xxx Il2rg^tm1Wjl/J,^{f m}

34859 (NSG CAG-Cre/Esr1) NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(CAG-cre/Esr1*)5Amc/J, ^f

35855 (DRAGA) NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl Tg(HLA-A/H2-D/B2M)Dvs Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/J ^{e i j}

^b Provided with permission of Children’s Hospital Cincinnati and the British Columbia Cancer Agency
^c Provided with permission from Merck Sharp & Dohme Corp.
^d Provided with permission from University of Virginia Patent Foundation
^e Rag1 allele provided with permission of  Massachusetts Institute of Technology
^f Available for academic research use only.
^g Hprtb-m3 allele - James Eshleman,  John Hopkins University.
^h PGK1-KITLG*220 allele with permission from University of Massachusetts US 8,431,767
ⁱ Provided with permission of the Naval Medical Research Center.
^j HLA-DRA,HLA-DRB1*0401 allele  provided with permission of Hoffmann-La Roche Inc.
^k H2-D<b> H2-K<b> provided with permission of President and Fellows of Harvard College
^l Hgftm1.1(HGF)Aveo provided with permission of AVEO Pharmaceuticals – academic use only
^m Mouse created using CRISPR technology, see both separate Limited Licenses,
https://www.jax.org/~/media/Files/license-letters/CARIBOU.pdf
https://www.jax.org/~/media/Files/license-letters/CRISPRCAS9.pdf
ⁿ Rag2tm1Fwa allele - Frederick W. Alt, Columbia University
^o Cd47tm1Fpl allele - Dr. Frederik Lindberg, Washington University
^p Provided with permission from University of Wisconsin and Dr. James Thomson
^q Subject to US Patent 7,642,401 filed by National University Corporation, Nara Institute of Science and Technology, Nara (JP); University of Geneva, Geneva (CH)
^r HLA alleles (Dr. Chella David) provided with permission of the Mayo Clinic Rochester
^s SERPINA1*E342K allele with permission from University of Pittsburgh and Baylor College of Medicine
^t Distributed under an agreement with Technische Universitat Dresden
^u CD68 allele - Dr. David R Greaves, University of Oxford
^v Cd274<tm1Shr>allele - Dr. Arlene H Sharpe, Harvard Medical School
^w Provided with permission from Stanford University
^y Cybb^em1Hmal knock-out allele provided with permission from NIH.
^Z Provided with permission from University of Massachusetts

^a1 Provided with permission from Princeton University.
^a2 Tg(IL15) provided with permission from Roswell Park Institute.
^a3 Mouse created using TALEN technology, see separate Limited License, https://www.jax.org/~/media/Files/license-letters/TAL_MICE.pdf
^a4 Created with ZFN Technology.
^a5 Provided with permission from University of Nebraska Medical Center.