HuMM Agreement - Schedule A

Schedule "A" (updated August 4th, 2023)

Description of MICE

11066 (NSG-Porcine tg) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2YgyTg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ,f

12479 (NSG-DRA4) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckRolyJ,c f

12480 (NSG-Hprt) - NOD.Cg-Prkdcscid Il2rgtm1Wjl Hprtb-m3/EshJ,fg

14553 (NSG hHGFki) NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J,f l

17637 (NSG Ab1 DLR4) NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Doi Tg(HLA-DRB1)31Dmz/SzJ,f

17914 (NRG-DRA, DRAG Mouse) NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/ScasJ,e i j

18454 (NRG FAH) NOD.Cg-Rag1tm1Mom Fahem1Mvw Il2rgtm1Wjl/MvwJ, e f a4

21885 (NSG-Abo) NOD.Cg-Prkdcscid H2-Ab1tm1Doi Il2rgtm1Wjl/SzJ

21937 (NSG-GFP) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ,f

25730 (B6-RCd47g) B6.129S-Rag2tm1Fwa Cd47tm1Fpl Il2rgtm1Wjl/J,f n o

26014 (NRG-W-Kit 41 Eaves) NOD.Cg-Rag1tm1Mom KitW-41J Il2rgtm1Wjl/EavJ, e f

26497 (NSG-W-Kit41 Wask) NOD.Cg-KitW-41J Prkdcscid Il2rgtm1Wjl/WaskJ,t

26561 (NSG-DQ8) NOD.Cg-Prkdcscid H2-Ab1tm1Doi Il2rgtm1Wjl Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ,r

26936 (NSG-DQ8 INS) NOD.Cg-Prkdcscid H2-Ab1tm1Doi Il2rgtm1Wjl Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(INS*)172Dvs/DvsJ, r

26997 (NSG CD68) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CD68-EGFP)1Drg/J,f u

27905 (NSG-Cd274) NOD.Cg-Prkdc<scid> Cd274<tm1Shr> Il2rg<tm1Wjl>/J,f v

27976 (NSG-RIP DTR) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(Ins2-HBEGF)6832Ugfm/SzJ,f q

29295 (NSG DR4) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/SzJ,r

29663 (NRG Dysf) NOD.Cg-Rag1tm1Mom Dysfprmd Il2rgtm1Wjl/McalJ, e f

29819 (NSG Gcg1-29KO) NOD.Cg-Gcgem1Dvs Prkdcscid Il2rgtm1Wjl/DvsJ,m f

30331 (NSG-DRA1) NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdcscid H2-Ab1tm1Doi Il2rgtm1Wjl/SzJ,c f

30442 (NRG-mdx) NOD.Cg-Rag1tm1Mom Dmdmdx-4Cv Il2rgtm1Wjl/McalJ,e w

30443 (NRG-Sgca) NOD.Cg-Rag1tm1Mom Sgcatm1Kcam Il2rgtm1Wjl/McalJ,e w

30533 (NRG hNTCP) NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(SLC10A1)15Mvw/MvwJ,f e a1

30547 (NSG C I/II B2m) NOD.Cg-B2mtm1Unc Prkdcscid H2dlAb1-Ea1 Il2rgtm1Wjl/SzJ,f

30610 (NSG-CYbb) NOD.Cg-Prkdcscid Cybbem1Hmal Il2rgtm1Wjl/HmalJ,f m y

31566 (NSG Abo DR4) NOD.Cg-Prkdcscid H2-Ab1tm1Doi Il2rgtm1Wjl Tg(H2-Ea-HLA-DRB1*0401*)1Dv/SzJ,r

31900 (NSG-cmah) NOD.Cg-Cmahem1Guru Prkdcscid Il2rgtm1Wjl/GuruJ,a5

32474 (NSG-SGM3-Abcd1Δ89) NOD.Cg-Prkdcscid Abcd1em2Lutzy Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ,b f  m

32927 (NSG DKO) NOD.Cg-Prkdcscid H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs Il2rgtm1Wjl/SzJ, m

33127 NOD.Cg-Rag1tm1Mom Flt3tm1Irl Mcph1Tg(HLA-A2.1)1Enge Il2rgtm1Wjl/J,def

34569 (NSG.OtcR129H) NOD.Cg-Prkdcscid Otcem1Xxx Il2rgtm1Wjl/J,f m

34859 (NSG CAG-Cre/Esr1) NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-cre/Esr1*)5Amc/J, f

35855 (DRAGA) NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)Dvs Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/J e i j

b Provided with permission of Children’s Hospital Cincinnati and the British Columbia Cancer Agency
c Provided with permission from Merck Sharp & Dohme Corp.
d Provided with permission from University of Virginia Patent Foundation
e Rag1 allele provided with permission of  Massachusetts Institute of Technology
f Available for academic research use only.
g Hprtb-m3 allele - James Eshleman,  John Hopkins University.
h PGK1-KITLG*220 allele with permission from University of Massachusetts US 8,431,767
i Provided with permission of the Naval Medical Research Center.
j HLA-DRA,HLA-DRB1*0401 allele  provided with permission of Hoffmann-La Roche Inc.
k H2-D<b> H2-K<b> provided with permission of President and Fellows of Harvard College
l Hgftm1.1(HGF)Aveo provided with permission of AVEO Pharmaceuticals – academic use only
m Mouse created using CRISPR technology, see both separate Limited Licenses,
n Rag2tm1Fwa allele - Frederick W. Alt, Columbia University
o Cd47tm1Fpl allele - Dr. Frederik Lindberg, Washington University
p Provided with permission from University of Wisconsin and Dr. James Thomson
q Subject to US Patent 7,642,401 filed by National University Corporation, Nara Institute of Science and Technology, Nara (JP); University of Geneva, Geneva (CH)
r HLA alleles (Dr. Chella David) provided with permission of the Mayo Clinic Rochester
s SERPINA1*E342K allele with permission from University of Pittsburgh and Baylor College of Medicine
t Distributed under an agreement with Technische Universitat Dresden
u CD68 allele - Dr. David R Greaves, University of Oxford
v Cd274<tm1Shr>allele - Dr. Arlene H Sharpe, Harvard Medical School
w Provided with permission from Stanford University
y Cybbem1Hmal knock-out allele provided with permission from NIH.
Z Provided with permission from University of Massachusetts

a1 Provided with permission from Princeton University.
a2 Tg(IL15) provided with permission from Roswell Park Institute.
a3 Mouse created using TALEN technology, see separate Limited License,
a4 Created with ZFN Technology.
a5 Provided with permission from University of Nebraska Medical Center.