| MODEL | JAX # | DESCRIPTION | SOURCE | NOMENCLATURE | REFERENCE |
|---|
| LOAD1 = APOE4/Trem2*R47H | 28709 | APOE4 & Trem2R47H KI | MODEL-AD | B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J | PMID:34707490 |
| LOAD2 = Abeta/APOE4/Trem2*R47H | 30670 | Humanized Aβ1-42, APOE4 & Trem2R47H KI | MODEL-AD | B6.Cg-Apoetm1.1(APOE*4)Adiuj Appem1Adiuj Trem2em1Adiuj/J | PMID:38735056
|
| LOAD3 = Abeta/APOE4/MAPT(H1.0) | 37778 | Humanized Aβ1-42, APOE4 & humanized TAU of H1 haplotype | MODEL-AD | B6(SJL)-Apoetm1.1(APOE*4)Adiuj Tc(HSA17)2Mdk Appem1Adiuj/J | |
| Abeta/APOE4 | 34415 | Humanized Aβ1-42 & APOE4 | MODEL-AD | B6(SJL)-Apoetm1.1(APOE*4)AdiujAppem1Adiuj/J | |
| Abeta/APOE3 | 34455 | Humanized Aβ1-42 & APOE3 | MODEL-AD | B6(SJL)-Apoeem2(APOE*)AdiujAppem1Adiuj/J | |
| Abeta/MAPT(H1.0) | 38908 | Humanized Aβ1-42 & humanized TAU of H1 haplotype | MODEL-AD | B6.Cg-Tc(HSA17)2Mdk Appem1Adiuj/J | |
| MAD1 | 38104 | Humanized floxed Aβ1-42, APOE4 & humanized TAU of H2.1 haplotype | MODEL-AD (UCI) | B6.(Cg)-Apoetm1.1(APOE*4)AdiujTc(HSA17)1Mdk Apptm1.1Aduci/AduciJ | |
| MAD2 | 38105 | Humanized floxed Aβ1-42 with Swedish and Iberian mutations, APOE4 & humanized TAU of H2.1 haplotype | MODEL-AD (UCI) | B6.(Cg)-Apoetm1.1(APOE*4)AdiujTc(HSA17)1Mdk Appem2Aduci/AduciJ | |
