Late-onset AD base models

MODEL JAX # TYPE DESCRIPTION NOMENCLATURE REFERENCE
LOAD1 = APOE4/Trem2*R47H 28709 compound KI APOE4 & Trem2R47H KI B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J PMID:34707490
LOAD2 = Abeta/APOE4/Trem2*R47H 30670 compound KI Humanized Aβ1-42, APOE4 & Trem2R47H KI B6.Cg-Apoetm1.1(APOE*4)Adiuj Appem1Adiuj Trem2em1Adiuj/J PMID:38735056
LOAD3 = Abeta/APOE4/MAPT(H1.0) 37778 compound KI Humanized Aβ1-42, APOE4 & humanized TAU of H1 haplotype B6(SJL)-Apoetm1.1(APOE*4)Adiuj Tc(HSA17)2Mdk Appem1Adiuj/J
Abeta/APOE4 34415 compound KI Humanized Aβ1-42 & APOE4 B6(SJL)-Apoetm1.1(APOE*4)AdiujAppem1Adiuj/J
Abeta/APOE3 34455 compound KI Humanized Aβ1-42 & APOE3 B6(SJL)-Apoeem2(APOE*)AdiujAppem1Adiuj/J
Abeta/MAPT(H1.0) 38908 compound KI Humanized Aβ1-42 & humanized TAU of H1 haplotype B6.Cg-Tc(HSA17)2Mdk Appem1Adiuj/J