| MODEL |
JAX # |
TYPE |
DESCRIPTION |
NOMENCLATURE |
REFERENCE |
| LOAD1 = APOE4/Trem2*R47H |
28709 |
compound KI |
Humanized Aβ1-42, APOE4 & Trem2R47H KI |
B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J |
PMID:34707490 |
| LOAD2 = Abeta/APOE4/Trem2*R47H |
30670 |
compound KI |
Humanized Aβ1-42, APOE4 & Trem2R47H KI |
B6.Cg-Apoetm1.1(APOE*4)Adiuj Appem1Adiuj Trem2em1Adiuj/J |
PMID:38187716
|
| LOAD3 = Abeta/APOE4/MAPT(H1.0) |
37778 |
compound KI |
Humanized Aβ1-42, APOE4 & humanized TAU of H1 haplotype |
B6(SJL)-Apoetm1.1(APOE*4)Adiuj Tc(HSA17)2Mdk Appem1Adiuj/J |
|
| Abeta/APOE4 |
34415 |
compound KI |
Humanized Aβ1-42 & APOE4 |
B6(SJL)-Apoetm1.1(APOE*4)AdiujAppem1Adiuj/J |
|
| Abeta/APOE3 |
34455 |
compound KI |
Humanized Aβ1-42 & APOE3 |
B6(SJL)-Apoeem2(APOE*)AdiujAppem1Adiuj/J |
|
| Abeta/MAPT(H1.0) |
38908 |
compound KI |
Humanized Aβ1-42 & humanized TAU of H1 haplotype |
B6.Cg-Tc(HSA17)2Mdk Appem1Adiuj/J |
|