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Gene Replacement Models

MODEL	JAX #	TYPE	DESCRIPTION	SOURCE	NOMENCLATURE	REFERENCE
APOE3-GR	38918	Genome replacement	A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC2	Koob	B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J	PMID:38343132
APOE4-GR	38919	Genome replacement	A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC2	Koob	B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J	PMID:38343132
APP-GR	38920	Genome replacement	350kB human construct replacing mouse App	Koob	B6J.B6N-App^{tm1.1(APP)Mdk}/J	PMID:38343132
MAPT(H1.0)-GR	35398	Genome replacement	190kB human construct of H1 haplotype replacing mouse Mapt	Koob	B6J.B6N-Tc(HSA17)2Mdk/J	PMID:38343132
MAPT(H2.1)-GR	33668	Genome replacement	190kB human construct of H2 haplotype replacing mouse Mapt	Koob	B6J.B6N(CBA)-Tc(HSA17)1Mdk/J	PMID:38343132
MAPT(H1.0*)P301L-GR	37420	Genome replacement	190kB human construct of H1 haplotype with P301L variant replacing mouse Mapt	Koob	B6J.B6N-Tc(HSA17*P301L)1Mdk/J	PMID:38343132
MAPT(H1.0*N279K)-GR	35794	Genome replacement	190kB human construct of H1 haplotype with N279K risk variant replacing mouse Mapt	Koob	B6J.B6N(Cg)-Tc(HSA17*N279K)1Mdk/J	PMID:38343132
MAPT 10IVS+16 C>T	36664	Genome replacement	190kB human construct of H1 haplotype with non-coding C to T (rs63751011) mutation in intron 10 replacing mouse Mapt	Koob	B6(Cg)-Tc(HSA17*)1Mdk/J	PMID:38343132
PSEN1-GR	39177	Genome replacement	106kB human construct replacing the mouse Psen1 locus	Koob	B6J.B6N-Psen1^{tm1.1(PSEN1)Mdk}/J	PMID:38343132
SNCA-GR WT	39166	Genome replacement	158kB of the human SNCA genomic region replaces the mouse Snca locus	Koob	B6J.B6N-Snca^{tm1.1(SNCA)Mdk}/J	PMID:38343132
SNCA-GR A53T	39167	Genome replacement	158kB of the human SNCA genomic region with the A53T mutation replaces the mouse Snca locus	Koob	B6J.B6N-Snca^{tm2.1(SNCA*A53T)Mdk}/J	PMID:38343132
SNCA-GR E46K	39168	Genome replacement	158kB of the human SNCA-GR E46K genomic region with the E46K mutation replaces the mouse Snca locus	Koob	B6J.B6N-Snca^{tm3.1(SNCA*E46K)Mdk}/J	PMID:38343132
TARDBP-GR	39101	Genome replacement	65kB human TARDBP genomic region replacing the mouse Tardbp locus	Koob	B6J.B6N-Tardbp^{tm1.1(TARDBP)Mdk}/J	PMID:38343132
TREM2-GR wt	39172	Genome replacement	280kB human TREM2 genomic region (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.	Koob	C57BL/6-Tc(HSA6)1Mdk/J	PMID:38343132
TREM2-GR*R47H	39173	Genome replacement	280kB human TREM2 genomic region with the R47H AD risk variant (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.	Koob	C57BL/6-Tc(HSA6_TREM2*R47H)1Mdk/J	PMID:38343132
TREM2-GR rs9357347-C	39174	Genome replacement	280kB human TREM2 genomic region with a protective non-coding SNP (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.	Koob	C57BL/6-Tc(HSA6*rs9357347-C)1Mdk/J	PMID:38343132
P1At (3X-GR)	39175	Genome replacement	MAPT(H2.1)-GR; PSEN1-GR; APP-GR	Koob	B6J.B6N(CBA)-Tc(HSA17)1Mdk Psen1tm1.1(PSEN1)Mdk Apptm1.1(APP)Mdk/J

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