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Gene Replacement Models

MODELJAX #DESCRIPTIONSOURCENOMENCLATUREREFERENCE
APOE3-GR38918A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC2KoobB6J.B6N-Tc(HSA19*APOE_i3)1Mdk/JPMID:38343132
APOE4-GR38919A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC2KoobB6J.B6N-Tc(HSA19*APOE_i4)1Mdk/JPMID:38343132
APP-GR38920350kB human construct replacing mouse AppKoobB6J.B6N-Apptm1.1(APP)Mdk/JPMID:38343132
MAPT(H1.0)-GR35398190kB human construct of H1 haplotype replacing mouse MaptKoobB6J.B6N-Tc(HSA17)2Mdk/JPMID:38343132
MAPT(H2.1)-GR33668190kB human construct of H2 haplotype replacing mouse MaptKoobB6J.B6N(CBA)-Tc(HSA17)1Mdk/JPMID:38343132
MAPT(H1.0*)L266V-GR40834190kB human construct of H1 haplotype with L266V variant replacing mouse MaptKoobC57BL/6-Isr(HSA17;MAPT*L266V)6Mdk/JPMID:38343132
MAPT(H1.0*)G272V-GR40835190kB human construct of H1 haplotype with G272V variant replacing mouse MaptKoobC57BL/6-Isr(HSA17;MAPT*G272V)7Mdk/JPMID:38343132
MAPT(H1.0*N279K)-GR35794190kB human construct of H1 haplotype with N279K risk variant replacing mouse MaptKoobB6J.B6N(Cg)-Tc(HSA17*N279K)1Mdk/JPMID:38343132
MAPT(H1.0*)P301L-GR37420190kB human construct of H1 haplotype with P301L variant replacing mouse MaptKoobB6J.B6N-Tc(HSA17*P301L)1Mdk/JPMID:38343132
MAPT(H1.0*)S320F-GR40796190kB human construct of H1 haplotype with S320F variant replacing mouse MaptMODEL-ADB6J.Cg-Isr(HAS17;MAPT*S320F)1Adiuj/AdiujJ
MAPT(H1.0*)R406W-GR40815190kB human construct of H1 haplotype with R406W variant replacing mouse MaptMODEL-ADB6J.Cg-Isr(HAS17;MAPT*R406W)2Adiuj/AdiujJ
MAPT 10IVS+16 C>T36664190kB human construct of H1 haplotype with non-coding C to T (rs63751011) mutation in intron 10 replacing mouse MaptKoobB6(Cg)-Tc(HSA17*)1Mdk/JPMID:38343132
PSEN1-GR39177106kB human construct replacing the mouse Psen1 locusKoobB6J.B6N-Psen1tm1.1(PSEN1)Mdk/JPMID:38343132
SNCA-GR WT39166158kB of the human SNCA genomic region replaces the mouse Snca locusKoobB6J.B6N-Sncatm1.1(SNCA)Mdk/JPMID:38343132

SNCA-GR A53T39167158kB of the human SNCA genomic region with the A53T mutation replaces the mouse Snca locusKoobB6J.B6N-Sncatm2.1(SNCA*A53T)Mdk/JPMID:38343132
SNCA-GR E46K39168158kB of the human SNCA-GR E46K genomic region with the E46K mutation replaces the mouse Snca locusKoobB6J.B6N-Sncatm3.1(SNCA*E46K)Mdk/JPMID:38343132
TARDBP-GR3910165kB human TARDBP genomic region replacing the mouse Tardbp locusKoobB6J.B6N-Tardbptm1.1(TARDBP)Mdk/JPMID:38343132
TREM2-GR wt39172280kB human TREM2 genomic region (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.KoobC57BL/6-Tc(HSA6)1Mdk/JPMID:38343132
TREM2-GR*R47H39173280kB human TREM2 genomic region with the R47H AD risk variant (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.KoobC57BL/6-Tc(HSA6_TREM2*R47H)1Mdk/JPMID:38343132
TREM2-GR rs9357347-C39174280kB human TREM2 genomic region with a protective non-coding SNP (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus.KoobC57BL/6-Tc(HSA6*rs9357347-C)1Mdk/JPMID:38343132
P1At (3X-GR)39175MAPT(H2.1)-GR; PSEN1-GR; APP-GRKoobB6J.B6N(CBA)-Tc(HSA17)1Mdk Psen1tm1.1(PSEN1)Mdk Apptm1.1(APP)Mdk/J
P1G209VAτ (3X-GR)40830MAPT(H2.1)-GR; PSEN1-GR*G209V; APP-GRKoobC57BL/6-Isr(HSA17)1Mdk Psen1tm2.1(PSEN1*G209V)Mdk Apptm1.1(APP)Mdk/J
P1A246EAτ (3X-GR)40831MAPT(H2.1)-GR; PSEN1-GR*A246E; APP-GRKoobC57BL/6-Isr(HSA17)1Mdk Psen1tm3.1(PSEN1*A246E)Mdk Apptm1.1(APP)Mdk/J
P1V272AAτ (3X-GR)40832MAPT(H2.1)-GR; PSEN1-GR*V272A; APP-GRKoobC57BL/6-Isr(HSA17)1Mdk Psen1tm4.1(PSEN1*V272A)Mdk Apptm1.1(APP)Mdk/J
P1E280AAτ (3X-GR)40833MAPT(H2.1)-GR; PSEN1-GR*E280A; APP-GRKoobC57BL/6-Isr(HSA17)1Mdk Psen1tm5.1(PSEN1*E280A)Mdk Apptm1.1(APP)Mdk/J
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