References

Chen J, Astle CM, Harrison DE. 1999. Development and aging of primitive hematopoietic stem cells in BALB/cBy mice. Exp Hematol. 27:928-935.

Chen, J, Astle CM, Harrison DE. 2000a. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol. 28:442-50.

Chen J, Astle CM, Müller-Sieburg CE, Harrison DE. 2000b. Primitive hemopoietic stem cell function in vivo is uniquely high in the CXB-12 mouse strain. Blood 96(13):4124-4131.

Chen J, Astle CM, Harrison DE. 2003. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol. 31:1097-1103.

Cho RH, Müller-Sieburg CE. 2000. High frequency of long-term culture-initiating cells retain in vivo repopulation and self-renewal capacity. Exp Hematol. 28:1080-6.

de Haan G, Szilvassy SJ, Meyerrose TE, Dontje B, Grimes B, Van Zant G. 2000. Distinct functional properties of highly purified hematopoietic stem cells from mouse strains differing in stem cell numbers. Blood. 96:1374-9.

Ertl, RP, Harrison DE. 2008. Dietary Restriction: A model system probing the cell fate decision between cancer and senescence. Li, S, ed. Springer. Mouse models of human blood cancers: basic research and pre-clinical applications.Chapter 6: 133-156.

Ertl RP, Harrison DE. 2010. Hematopoietic stem cell aging. In: Regenerative Medicine. Scott EW, Fisher RC (eds). Chapter 38 (in press). Jones and Bartlett, Boston MA.

Ertl RP, Chen J, Astle CM, Duffy TM, Harrison DE. 2008. Effects of dietary restriction on hematopoietic stem cell aging are genetically regulated. BLOOD. Oct 19 111(3):1709-1716.

Fazekas de St Groth S. 1982. The evaluation of limiting dilution assays. J. Immunol Methods. 49:R11-23.

Harrison DE. 1980. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood 55:77-81. 

Harrison DE, Zhong RK. 1992. The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation. Proc Nat Acad Sci USA. 89:10134-8.

Harrison DE, Astle CM, Delaittre JA. 1978. Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. J Exp Med. 147:1526-31.

Harrison DE, Astle CM, Lerner C. 1988. Number and continuous proliferative pattern of transplanted primitive immunohemopoietic stem cells. Proc Natl Acad Sci USA 85:822-826.

Harrison DE, Astle CM, Stone M. 1989. Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J Immunol. 142:3833-3840.

Harrison DE, Stone M, Astle CM. 1990. Effects of transplantation on the primitive immunohematopoietic stem cell (PSC). J Exp Med. 172:431-437.

Harrison DE, Jordan CT, Zhong RK, Astle CM. 1993. Primitive hematopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol.21:206-19.

Jordan CT, Lemischka IR. 1990. Clonal and systemic analysis of long term hematopoiesis in the mouse. Genes and Development. 4:220-32.

Morrison SJ, Weissman IL. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1:661-63.

Müller-Sieburg CE, Riblet R. 1996. Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1. J Exp Med. 183:1141-50.

Sharma Y, Astle CM, Harrison DE. 2007. Heterozygous Kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol. 35:214-220.

Sharma Y, Flurkey K, Astle CM, Harrison DE. 2005. Mice severely deficient in growth hormone have normal hematopoiesis. Exp Hematol. 33:776-83.

Spangrude GJ, Brooks DM, Tumas DB. 1995. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood. 85:1006-16.

Stone M, Harrison DE. 1990. A stratified binomial marker model for bone-marrow repopulation experiments. J Theor Biol. 144:267-273.

TeKippe M, Harrison DE, Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice.Exp Hematol. 31:521-7.

Yuan R, Astle CM, Chen J, Harrison DE. 2005. Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp Hematol. 33:243-250.

Zhong RK, Astle CM, Harrison DE. 1996. Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid precursors defined by competitive limiting dilution analysis in vivo. J. Immunol. 157:138-145.