Available data

Activated lipid (HDL and LDL)

Table VI.9. C57BL/6J males and B6CBAT6F1 females: changes in weight among activated lipid fed, control, and colony control mice.

Figure VI.6. B6CBAT6F1 females: life span curves for activated lipid fed and control mice

Figure VI.7. Young mice (30 to 210 days): weight comparisons among lipid fed, control, and colony control mice

Figure VI.8. Old mice (860 to 963 days): weight comparisons among lipid fed, control, and colony control mice

Table VI.10. Biomarker values for young and old treated mice compared to controls

Chromium picolinate

Figure VI.9. Life span curves: treated vs. controls

Figure VI.10. Food consumption: comparisons between treated mice and untreated controls

Figure VI.11. Weight: comparisons between treated mice and untreated controls

Figure VI.12. Tail length: comparisons between treated mice and untreated controls

Distilled water

Figure VI.13. C57BL/6J males and females: combined life spans of treated and untreated mice

Figure VI.14. C57BL/6J males and females: weight comparisons of treated and untreated mice

Figure VI.15. C57BL/6J males and females: tail length comparisons of treated and untreated mice

Exercise

Figure VI.16. Effects of voluntary wheel running on life span

1We have had many requests for baseline life span statistics for various mouse strains. Following are life span data for standard inbred laboratory strains and for other strains we have studied in the Harrison Lab.

Commonly used JAX Mice and crosses (Study 1 and Study 2)

Historical life span summaries for commonly used strains of JAX Mice and F1 hybrids from some of these mice.

All mice were virgins, with the exception of C57BL/6J retired male breeders. All were fed The Jackson Laboratory,
6% fat, pasteurized diet (96WA; Emory Morse, Old Guilford, CT) ad lib.
Date range when mice were born: Study 1, 1976-1980; Study 2, (1981-1983).
aF1 hybrid of C57BL/6J female and CBA/CaJ male.
bF1 hybrid of C57BL/6J female and CBA/CaH-T(14;15)6Ca/J male.
cF1 hybrid of C57BL/6J female and DBA/2J male.
dF1 hybrid of WB/ReJ KitW/J female and C57BL/6J male. (Wild-type animals used for study.)
eF1 hybrid of WC/ReJ KitlSl/J female and C57BL/6J male. (Wild-type animals used for study.)

Twelve strains of commonly used laboratory mice (Study 2)

Survival curves for females of 12 inbred strains of laboratory mice. For comparison purposes, Panel A includes all 12 strains. For clarity, Panels B, C, and D include subsets of Panel A data. For tabular data, refer to Table VI.2, below.

Our diallele cross

Our 4-way crosses, selected for life span

Figure VI.2. Mean life spans for 1ML and 2ML males and females.

Table VI.5 provides 2 comparisons: 1) mice that were "Tested" vs. mice that were "Not tested"; 2) "Not tested" mice identified as moribund and necropsied vs. "Not necropsied" mice that were found dead and not necropsied. This second comparison indicates the accuracy of being able to identify old mice just before they die.

Table VI.5. Effects of biomarker testing on life span; the accuracy of identifying mice as moribund.

Mice in good health at 480 days of age, when study began. Tested = non-lethal biomarker test battery at 16 and 22 months of age; necropsied when moribund. Not tested = unused, but necropsied when moribund. Not necropsied = unused. Both practice and demonstrated expertise are required to recognize when mice are moribund.

Table VI.6. Effects of biomarker testing (at 495 and 675 days) on life spans of mice.

Table VI.7. Biomarker test results at 495 days.

PS=Paw Strength, TW=Tight Wire clinging time, OF=Open Field Activiy, BOLI=Fecal deposits during OF, WGT=Body Weight, AST=Avertin Sleeptime, TL=Tail Length, HR=Hair Regrowth after 25 days, HCT=Hematocrit, HB=Hemaglobin, UC=Urine Concentration Ability after 36 hours, TTC=Tail Tendon Collagen breaking tiime, WH=Wound Healing time after extraction of TTC.

Table VI.8. Biomarker test results at 675 days.

Figure VI.3. Life spans of C57BL/6J males and females.

Figure VI.4. Life spans of CBA/CaH-T(14;15)6Ca/J males and females

Figure VI.5. Life spans of B6CBAT6F1 males and females