Nominations are welcome from patients, families, foundations, family
organizations, researchers, and clinicians by contacting our center at precisiongenetics@jax.org or
using the links below.
General Nomination Guidance
:
Priority will be given for nominations in which our center can work closely
and collaboratively with the clinicians, researchers and patient
organizations to develop models that can be readily available to the global
research community in support of advancing therapeutics for disease. Other
primary criteria for nomination selection include:
- Novelty and need within the research community for mouse models for this
disease
- Evidence the variant and gene cause the disease
- Feasibility for modeling by our center
- Potential for preclinical applications
Nomination process
- Interested parties contact our center to discuss the variant you propose
to model. Please contact us via one of the following methods:
Contact by Email
Contact by Form
- Nominators will be contacted via email to confirm submission. In
addition, our staff will solicit and gather additional information about
the mutation, patient phenotypes, plans for evaluating the new model as
well as potential therapeutics that may be amenable to the type of
mutation. Conference calls to further discuss the project needs and gather
information are typically scheduled within a week or two from initial
contact.
- Variant summary is compiled and evaluated by the review committee
- If selected, experimental plan is devised in conjunction with the
nominator(s) to generate the mouse model and conduct the initial evaluation
of clinically relevant phenotypes. Once the plan is approved the project is
initiated.
Our center will also consider project nominations from the community where
a mouse model may already exist but may require additional evaluation to
establish the mouse strain as a model for human disease or to gather
preclinical data to advance a therapeutic toward IND approval.