After working at Yale for seven years studying type 2 diabetes in obese adolescents, I came to JAX in 2014 to join the Stitzel lab. Using a broad spectrum of genetic and epigenetic techniques (e.g., ChIP-seq, RNA-seq, ChIA-PET, ATAC-seq) to study the epigenome of human islets and rodent beta-cell lines we are able to identify “stretch”enhancers involved in type 2 diabetes. By breaking them using CRISPR-Cas9 we will investigate altered gene expression and insulin signaling to understand their function.
Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S., A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. 2016 Mar;65(3):610-8. doi: 10.2337/db15-1478.