Romy Kursawe, Ph.D.

Research Assistant IV

Try to understand how genetic variation in non-coding, regulatory DNA sequences alter islet gene expression to contribute to islet dysfunction and type 2 diabetes (T2D).

After working at Yale for seven years studying type 2 diabetes in obese adolescents, I came to JAX in 2014 to join the Stitzel lab. Using a broad spectrum of genetic and epigenetic techniques (e.g., ChIP-seq, RNA-seq, ChIA-PET, ATAC-seq) to study the epigenome of human islets and rodent beta-cell lines we are able to identify “stretch”enhancers involved in type 2 diabetes. By breaking them using CRISPR-Cas9 we will investigate altered gene expression and insulin signaling to understand their function.